Relations between the ionization or recombination flux and the emission radiation for hydrogen and helium in plasma

On the basis of the collisional-radiative models for neutral hydrogen, and neutral and ionized helium, the relationship between the ionization flux or the recombination flux and the photon emission rate of a representative visible line of each species is investigated. It is found that both fluxes are proportional to the photon emission rate and that the proportionality factor depends rather weakly on the plasma parameters in the ranges of practical interest. This implies that the observed emission line intensity can be a good measure of the ionization flux or the recombination flux. The relation between the total radiation power rate and the ionization or recombination flux is also considered. For a hydrogen plasma in ionization balance the Balmer-alpha line intensity takes the maximum value near the optimum temperature of 1.3 eV, while for plasmas out of ionization balance it takes the minimum near that temperature. This latter characteristic corresponds to the recently observed "inverse edge-localized mode" in divertor plasmas. For neutral hydrogen and ionized helium, it is found that in the recombining plasma of low electron temperature, T_e, and density, n_e, the radiation energy close to the ionization potential of the ground state is emitted during one recombination event. In the ionizing plasma of high Te and low n_e, a similar amount of energy is emitted during one ionization event. Emission line intensities of hydrogen and helium were measured in the Large Helical Device, and the time variation of n_e at the initial and final phases of a discharge was estimated. The results agreed well with the interferometer measurement, and this indicated that the variation of n_e was dominated by their ionization or recombination processes rather than by diffusion. The total radiation energy of hydrogen and helium in the recombining phase was found to be less than 1% of the stored energy of the plasma

Design and optimization of tapered structure of near-field fiber probe based on FDTD simulation

The finite-difference time-domain method was employed to simulate light propagation in tapered near-field fiber probes with small metal aperture. By conducting large-volume simulations, including tapered metal-cladding waveguide and connected optical fiber waveguide, we illustrated the coupling between these guiding modes as well as the electric field distribution in the vicinity of the aperture. The high collection efficiency of a double-tapered probe was reproduced and was ascribed to the shortening of the cutoff region and the efficient coupling to the guiding mode of the optical fiber. The dependence of the efficiency on the tapered structure parameters was also examined.Comment: 4 Pages including 3 Figure

Quantitative Tactile Examination Using Shape Memory Alloy Actuators for the Early Detection of Diabetic Neuropathy

Diabetic neuropathy (DPN) is asymptomatic in its early phases but can cause serious complications as it progresses. Most DPN tests are cumbersome and produce only qualitative assessments, and simpler approaches that yield quantitative results are needed. Techniques that allow patients to perform examinations themselves would be especially valuable. In this study, we focused on quantifying the decline in tactile sensation associated with DPN and developed a measurement device that used a thin shape memory alloy (SMA) wire as the actuator. An ON/OFF pulse current caused the wire to shrink and expand. This vibration was amplified by a round-headed pin, allowing even DPN patients with reduced tactile sensitivity to detect the stimuli generated when lightly touching the pin with their fingertips. The tactile stimuli were ranked into 30 levels of intensity. A key advantage of the device is that it can be used by patients themselves, returning quantified results within minutes. Although developed for DPN, the method can be applied to the detection of peripheral neuropathy in general

『ジャスパー・ジョーンズ Jasper Jones』と子供 -物語を「自分たちのもの」にすること

departmental bulletin pape

小特集：磁場閉じ込め核融合装置における水素原子分子輸送研究の新展開 ２．要素モデルの統合が実現する壁から プラズマまでを含めた中性粒子輸送研究

非接触をはじめとするダイバータプラズマの諸現象を理解するため，壁での粒子リサイクリング，荷電粒子，中性粒子を扱うコードの統合を進めている．水素分子には，電子状態のほか，回転および振動の内部自由度があり，分子活性化再結合をはじめとするプラズマ中の水素分子の各種の反応速度係数は，水素分子の始状態の振動・回転量子数により，数桁にわたって変化する．また，低温のプラズマでは，プラズマ中の電子やプロトン衝突による水素分子の振動・回転励起がプラズマのエネルギー損失チャンネルとして重要と考えられる．このため，水素分子の振動・回転状態を中性粒子やプラズマの輸送と組み合わせて解く統合モデルを開発した

小児急性リンパ性白血病のL-アスパラギナーゼを含む寛解導入療法ではトロンピン・プラスミン生成試験において著明な線溶抑制を主体とする凝固障害を示す。

Background: L-asparaginase (L-Asp)-associated thromboembolisms are serious complications in pediatrics patients with acute lymphoblastic leukemia (ALL), especially at ≥10.0 years old, but the pathogenesis remains to be clarified. Procedure: We conducted a multicenter, prospective study of 72 patients with ALL aged 1.0 to 15.2 years treated with either a Berlin-Frankfurt-Münster (BFM) 95-ALL oriented regimen or Japan Association of Childhood Leukemia Study ALL-02 protocol. We divided patients into each treatment protocol and investigated the dynamic changes in coagulation and fibrinolysis using simultaneous thrombin and plasmin generation assay. Patients' plasma samples were collected at the prephase (T0), intermittent phase (T1), and postphase of L-Asp therapy (T2), and postinduction phase (T3). Measurements of endogenous thrombin potential (T-EP) and plasmin peak height (P-Peak) were compared to normal plasma. Results: None of the cases developed thromboembolisms. Median ratios of T-EP and P-Peak for the controls in the JACLS group were 1.06 and 0.87 (T0), 1.04 and 0.71 (T1), 1.02 and 0.69 (T2), and 1.20 and 0.92 (T3), respectively, while those in the BFM group were 1.06 and 1.00 (T0), 1.04 and 0.64 (T1), 1.16 and 0.58 (T2), and 1.16 and 0.85 (T3), respectively. In particular, P-Peak ratios were depressed at T1 and T2 compared to T0 in the BFM group (P < .01). Moreover, P-Peak ratios in patients ≥10.0 years old were lower at T1 in the BFM group (P = .02). Conclusions: The results demonstrated that hemostatic dynamics appeared to shift to a hypercoagulable state with marked hypofibrinolysis associated with L-Asp therapy, especially in patients ≥10.0 years old following the BFM regimen.博士（医学）・甲第722号・令和元年12月5日© 2019 Wiley Periodicals, Inc.This is the pre-peer reviewed version of the following article: [https://onlinelibrary.wiley.com/doi/full/10.1002/pbc.28016], which has been published in final form at [https://doi.org/10.1002/pbc.28016]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions

Enhanced Recombinant Protein Productivity by Genome Reduction in Bacillus subtilis

The emerging field of synthetic genomics is expected to facilitate the generation of microorganisms with the potential to achieve a sustainable society. One approach towards this goal is the reduction of microbial genomes by rationally designed deletions to create simplified cells with predictable behavior that act as a platform to build in various genetic systems for specific purposes. We report a novel Bacillus subtilis strain, MBG874, depleted of 874 kb (20%) of the genomic sequence. When compared with wild-type cells, the regulatory network of gene expression of the mutant strain is reorganized after entry into the transition state due to the synergistic effect of multiple deletions, and productivity of extracellular cellulase and protease from transformed plasmids harboring the corresponding genes is remarkably enhanced. To our knowledge, this is the first report demonstrating that genome reduction actually contributes to the creation of bacterial cells with a practical application in industry. Further systematic analysis of changes in the transcriptional regulatory network of MGB874 cells in relation to protein productivity should facilitate the generation of improved B. subtilis cells as hosts of industrial protein production

Functional 1,3a,6a-triazapentalene scaffold : Design of fluorescent probes for kinesin spindle protein (KSP)

1,3a,6a-Triazapentalene is a compact fluorescent chromophore. In this study, triazapentalene was used to modify a series of biphenyl-type inhibitors of kinesin spindle protein (KSP) to develop fluorescent probes for the intracellular visualization of this protein. Microscopic studies demonstrated that these novel triazapentalene-labeled compounds exhibited inhibitory activity towards KSP in cultured cells and provided important information concerning the intracellular distribution