One stage vs. Two stage Non-surgical Periodontal therapy and their effect on WBC count

ABSTRACT: Background: Bacteremia in periodontitis has been reported after oral examinations and periodontal pathogens have been shown to colonize distant sites. In periodontitis, leukocyte counts have been shown to be slightly elevated in patients compared to healthy subjects. The total number of white blood cells in the peripheral blood is a diagnostic measure of infection or inflammatory disease. The purpose of this study was to examine the effect of one stage and a two stage non-surgical therapy on total leukocyte count (TLC) and differential leukocyte count (DLC) in periodontitis patients.                                                                                                                                        Materials and methods: 30 periodontitis patients aged between 18 – 40 years were included. The patients were divided into two treatment groups-Group I:- 1 Phase Non-surgical therapy.Group II :-2 Phase Non-surgical therapy Sample collection: Group I: - 1) Pretreatment 2) 1 week after Non-surgical therapy. Group II: -1) Pretreatment 2) 1 week after 1st phase non-surgical therapy 3) 1 week after 2nd  phase  non-surgical therapy. The laboratory analysis of total leukocyte count and differential leukocyte count was performed.                                                                                                                                      Results: Both the groups showed significant reduction in the total leukocyte count after therapy                                                                                                                            Conclusion: Results indicate that a therapeutic intervention may have a systemic effect on blood count in periodontitis patients. Keywords: Total leukocyte count, Non surgical therapy, White blood cell count, Differential leukocyte count,&nbsp

Aggressive Periodontitis in a patient with Schizophrenia: Incidental or Accidental – A Case Report.

Background: Schizophrenia is a psychiatric illness characterized by thought disturbances, bizarre behaviors and cognitive impairments that may diminish a person’s abilities in the area of social relations, school or work and self care. Periodontitis may be defined as an inflammatory disease of the supporting tissues of the teeth by specific microorganisms, resulting in progressive destruction of the periodontal ligament & alveolar bone, pocket formation, recession, or both. The present paper reports a case of generalized aggressive periodontitis in a schizophrenic patient and discusses about common immune mediated pathogenesis in schizophrenia and aggressive periodontitis.Methods: A 31 year-old male patient showed very negligible oral hygiene index score and generalized deep pockets and mobility. Patient was a schizophrenic since 11 years and is on Risperidone for 5 years.Results: Generalized aggressive periodontitis display increased levels of prostaglandin E2. Increased monocytes in schizophrenia patients may result in activation of IL-6 which causes bone resorption. There is altered helper or suppressor T cell function and polyclonal B cell activation in generalized aggressive periodontitis. Schizophrenic patients also display decreased T helper-1 related immune parameter. Polyclonal activation of B cells is also seen as a common immunological finding in generalized aggressive periodontitis and schizophrenic patients.Conclusion: The present paper illustrates the commonality in immune parameters in an generalized aggressive periodontitis patient with schizophrenia. It may be hypothesized that there may be a two way relation between aggressive periodontitis and schizophrenia

Helicobacter Pylori in periodontal pockets of chronic periodontitis patients with and without type II diabetes mellitus: a randomized controlled trial

This randomized controlled study evaluated the association of Helicobacter pylori (H. pylori) with chronic periodontitis patients with and without type II Diabetes Mellitus. H. pylori is considered to be a pathogen responsible for gastritis, peptic ulcers and a risk factor for gastric cancer. The aim of the present study was to evaluate the association of H. pylori with chronic periodontitis patients with and without type II diabetes mellitus before and after treatment. The prevalence of H. pylori in periodontal pockets was determined by rapid urease test in a 36 patients, which were grouped as Group 1 (Healthy subjects), Group II (chronic periodontitis patients) and Group III (Chronic periodontitis patients with Type II Diabetes Mellitus), 12 in each group before treatment by collecting plaque samples. After treatment, 12 plaque samples were collected and prevalence H. pylori was detected. Group II and Group III had a significantly higher rate of positive results for H. pylori compared to healthy subjects before treatment. After treatment, H. pylori were not detected in Group II and in Group III Only one of 12 chronic periodontitis patients with Type II diabetes mellitus had H. pylori in the periodontal pocket. The prevalence of H. pylori did not differ significantly between the chronic periodontitis patients with and without type II diabetes mellitus. Meticulous scaling and root planning will reduce the prevalence of H. pylori in periodontal pockets