ИММУНОГЕНЕТИТИЧЕСКИЕ КРИТЕРИИ РАЗВИТИЯ ИНФЕКЦИОННО-АССОЦИИРОВАННЫХ ФОРМ РАКА ШЕЙКИ МАТКИ

The aim of the work is to carry out immunogenetic studies of women at risk of developing infectious-associated forms of cervical cancer and to develop immunogenetic criteria for the risk of cervical cancer. Materials and methods of the prospective study - 120 women participated in the study with the obligatory presence of voluntary medical consent in the age range from 19 to 42 years. Processing of biological material (biopsy, scrapings) was carried out using sets of “DNA technology” for human papillomavirus 16.18 types. The program included the study of cytolytic cells in cervical biopsies with phenotype CD3-CD16+CD56+. Normative values for a given pool of cells was defined as comparable in the peripheral blood in the range of 5-9%. Generirovanie pre sekvenirovanie material was performed at clinical Centre absolute. The basic pathologic-and-genetic mechanisms for its implementation and the Association with certain genotypes. As a result of studies, the risk criteria for the development of neoplastic process in women with different degrees of dysplasia infected with human papilloma virus 16/18 type were determined. It was revealed that the number of natural killers associated with genetic markers is a criterion of infection-induced process, including neoplastic. It is shown that the decrease in the activity of cytolytic cells associated with the genotype of human leukocyte antigen HLAV35, with the human papillomavirus 16\18 positive women, compared with groups II and III (human papillomavirus 16\18+), leads to the aggravation of the pathological process and the development of cervical cancer. The number of natural keellers associated with genetic markers is a criterion of infection-induced.Цель работы : проведение иммуногенетических исследований женщин с риском развития инфекционно-ассоциированных форм рака шейки матки и разработка иммуногенетитических критериев риска рака шейки матки. Материалы и методы проспективного исследования: участвовали 120 женщин при обязательном наличии добровольного медицинского согласия в возрастном диапазоне от 19 до 42 лет. Обработка биологического материала (биопсия, соскобы) проводилась с использованием наборов «ДНК-технология» на вирус папилломы человека 16, 18 типы. В программу было включено исследование клеток цитолитической направленности в биоптатах шейки матки с фенотипом CD3-CD16+CD56+. Нормативные значения данного пула клеток определялись как сопоставимые в периферической крови в пределах 5-9%. Генотирование с предварительным секвинированием материала проводили на клинической базе Центра «Абсолют». Изучены основные этиопатогенетические механизмы его реализации и ассоциации с определенными генотипами. В результате исследований были определены критерии риска развития неопластического процесса у женщин с различными степенями дисплазии, инфицированных вирус папилломы человека 16/18 типа. Выявлено, что количество натуральных киллеров, ассоциированных с генетическими маркерами, является критерием инфекционно-индуцированного процесса, в том числе и неопластического. Показано, что снижение активности цитолитических клеток, ассоциированной с генотипом человеческого лейкоцитарного антигена HLAВ35, с вирусом папилломы человека 16\18 позитивных женщин, по сравнению со II и III группами (вирус папилломы человека 16\18+), приводит к утяжелению патологического процесса и развитию рака шейки матки. Количество натуральных киллеров, ассоциированных с генетическими маркерами, является критерием инфекционно-индуцированного процесса, в том числе и неопластического

Delay times and reflection in chaotic cavities with absorption

Absorption yields an additional exponential decay in open quantum systems which can be described by shifting the (scattering) energy E along the imaginary axis, E+i\hbar/2\tau_{a}. Using the random matrix approach, we calculate analytically the distribution of proper delay times (eigenvalues of the time-delay matrix) in chaotic systems with broken time-reversal symmetry that is valid for an arbitrary number of generally nonequivalent channels and an arbitrary absorption rate 1/\tau_{a}. The relation between the average delay time and the ``norm-leakage'' decay function is found. Fluctuations above the average at large values of delay times are strongly suppressed by absorption. The relation of the time-delay matrix to the reflection matrix S^{\dagger}S is established at arbitrary absorption that gives us the distribution of reflection eigenvalues. The particular case of single-channel scattering is explicitly considered in detail.Comment: 5 pages, 3 figures; final version to appear in PRE (relation to reflection extended, new material with Fig.3 added, experiment cond-mat/0305090 discussed

Reducing nonideal to ideal coupling in random matrix description of chaotic scattering: Application to the time-delay problem

We write explicitly a transformation of the scattering phases reducing the problem of quantum chaotic scattering for systems with M statistically equivalent channels at nonideal coupling to that for ideal coupling. Unfolding the phases by their local density leads to universality of their local fluctuations for large M. A relation between the partial time delays and diagonal matrix elements of the Wigner-Smith matrix is revealed for ideal coupling. This helped us in deriving the joint probability distribution of partial time delays and the distribution of the Wigner time delay.Comment: 4 pages, revtex, no figures; published versio

Spin asymmetry A_1^d and the spin-dependent structure function g_1^d of the deuteron at low values of x and Q^2

We present a precise measurement of the deuteron longitudinal spin asymmetry A_1^d and of the deuteron spin-dependent structure function g_1^d at Q^2 < 1 GeV^2 and 4*10^-5 < x < 2.5*10^-2 based on the data collected by the COMPASS experiment at CERN during the years 2002 and 2003. The statistical precision is tenfold better than that of the previous measurement in this region. The measured A_1^d and g_1^d are found to be consistent with zero in the whole range of x.Comment: 17 pages, 10 figure

Gluon polarization in the nucleon from quasi-real photoproduction of high-pT hadron pairs

We present a determination of the gluon polarization Delta G/G in the nucleon, based on the helicity asymmetry of quasi-real photoproduction events, Q^2<1(GeV/c)^2, with a pair of large transverse-momentum hadrons in the final state. The data were obtained by the COMPASS experiment at CERN using a 160 GeV polarized muon beam scattered on a polarized 6-LiD target. The helicity asymmetry for the selected events is = 0.002 +- 0.019(stat.) +- 0.003(syst.). From this value, we obtain in a leading-order QCD analysis Delta G/G=0.024 +- 0.089(stat.) +- 0.057(syst.) at x_g = 0.095 and mu^2 =~ 3 (GeV}/c)^2.Comment: 10 pages, 3 figure

The Deuteron Spin-dependent Structure Function g1d and its First Moment

We present a measurement of the deuteron spin-dependent structure function g1d based on the data collected by the COMPASS experiment at CERN during the years 2002-2004. The data provide an accurate evaluation for Gamma_1^d, the first moment of g1d(x), and for the matrix element of the singlet axial current, a0. The results of QCD fits in the next to leading order (NLO) on all g1 deep inelastic scattering data are also presented. They provide two solutions with the gluon spin distribution function Delta G positive or negative, which describe the data equally well. In both cases, at Q^2 = 3 (GeV/c)^2 the first moment of Delta G is found to be of the order of 0.2 - 0.3 in absolute value.Comment: fits redone using MRST2004 instead of MRSV1998 for G(x), correlation matrix adde

Kaon Production and Kaon to Pion Ratio in Au+Au Collisions at \snn=130 GeV

Mid-rapidity transverse mass spectra and multiplicity densities of charged and neutral kaons are reported for Au+Au collisions at \snn=130 GeV at RHIC. The spectra are exponential in transverse mass, with an inverse slope of about 280 MeV in central collisions. The multiplicity densities for these particles scale with the negative hadron pseudo-rapidity density. The charged kaon to pion ratios are $K^+/\pi^- = 0.161 \pm 0.002 {\rm (stat)} \pm 0.024 {\rm (syst)}$ and $K^-/\pi^- = 0.146 \pm 0.002 {\rm (stat)} \pm 0.022 {\rm (syst)}$ for the most central collisions. The $K^+/\pi^-$ ratio is lower than the same ratio observed at the SPS while the $K^-/\pi^-$ is higher than the SPS result. Both ratios are enhanced by about 50% relative to p+p and $\bar{\rm p}$+p collision data at similar energies.Comment: 6 pages, 3 figures, 1 tabl

The COMPASS Experiment at CERN

The COMPASS experiment makes use of the CERN SPS high-intensitymuon and hadron beams for the investigation of the nucleon spin structure and the spectroscopy of hadrons. One or more outgoing particles are detected in coincidence with the incoming muon or hadron. A large polarized target inside a superconducting solenoid is used for the measurements with the muon beam. Outgoing particles are detected by a two-stage, large angle and large momentum range spectrometer. The setup is built using several types of tracking detectors, according to the expected incident rate, required space resolution and the solid angle to be covered. Particle identification is achieved using a RICH counter and both hadron and electromagnetic calorimeters. The setup has been successfully operated from 2002 onwards using a muon beam. Data with a hadron beam were also collected in 2004. This article describes the main features and performances of the spectrometer in 2004; a short summary of the 2006 upgrade is also given.Comment: 84 papes, 74 figure

A new measurement of the Collins and Sivers asymmetries on a transversely polarised deuteron target

New high precision measurements of the Collins and Sivers asymmetries of charged hadrons produced in deep-inelastic scattering of muons on a transversely polarised 6LiD target are presented. The data were taken in 2003 and 2004 with the COMPASS spectrometer using the muon beam of the CERN SPS at 160 GeV/c. Both the Collins and Sivers asymmetries turn out to be compatible with zero, within the present statistical errors, which are more than a factor of 2 smaller than those of the published COMPASS results from the 2002 data. The final results from the 2002, 2003 and 2004 runs are compared with naive expectations and with existing model calculations.Comment: 40 pages, 28 figure

Measurement of the Spin Structure of the Deuteron in the DIS Region

We present a new measurement of the longitudinal spin asymmetry A_1^d and the spin-dependent structure function g_1^d of the deuteron in the range 1 GeV^2 < Q^2 < 100 GeV^2 and 0.004< x <0.7. The data were obtained by the COMPASS experiment at CERN using a 160 GeV polarised muon beam and a large polarised 6-LiD target. The results are in agreement with those from previous experiments and improve considerably the statistical accuracy in the region 0.004 < x < 0.03.Comment: 10 pages, 6 figures, subm. to PLB, revised: author list, Fig. 4, details adde