Characterizing the Migratory Phenology and Routes of the Lazuli Bunting (Passerina amoena) in Northern Utah

Migratory species time their movements to follow changes in food and environmental resources throughout the year. Despite the ubiquity of migration in birds, little is still known about how birds select routes and time migrations. Recent advancements in miniaturized tracking devices now allow tracking of small birds throughout their annual life cycle, presenting opportunities for migratory ecology research at scales immeasurable in the past. Here we investigated the migratory ecology of a northern Utah, USA breeding population of Lazuli Bunting, a common songbird in western North America for which few migratory studies have been completed. We sought to compare breeding site arrival and departure of male and female buntings across an elevational gradient. We used encounter records of microchip-banded individuals visiting electronic birdfeeders to estimate migratory timings of each sex at high and low elevations. We additionally tagged a subset of birds with light sensing tags from which rough daily locations can be estimated throughout the year to determine where and how the individuals migrated. We found males to arrive before females at low elevation, while no differences between sexes was found in birds arriving at high elevations. This difference questions traditionally held thoughts on why most male birds typically arrive earlier than females. Our results suggest arrival timing by sex may be driven by differences in constraints on migratory timing rather than evolutionary selection for earlier arrival by males. Our tracking data revealed that tagged individuals migrated south to western Mexico for the non-breeding season. We found little support for a mid-migration stopover long enough to complete an annual molt, as had been suggested for the species. During spring migration, we observed two distinct migratory patterns: a direct route north made by three individuals, and a looping route through California and Nevada made by two birds. The latter route was significantly longer in distance but not duration. These differences suggest routes may be selected by individuals to balance between length, duration, and food availability of migration routes based on individual conditions each bird experiences. Our results collectively highlight the importance of investigating migratory ecology at the individual level. Such investigations are necessary in understanding how individual birds migrate and are ultimately necessarily for effective conservation of birds throughout their annual cycles

Star sightings by satellite for image navigation

Stars are sensed by one or more instruments (1, 2) on board a three-axis stabilized satellite, for purposes of assisting in image navigation. A star acquistion computer (64), which may be located on the earth, commands the instrument mirror (33, 32) to slew just outside the limb of the earth or other celestial body around which the satellite is orbiting, to look for stars that have been cataloged in a star map stored within the computer (64). The instrument (1, 2) is commanded to dwell for a period of time equal to a star search window time, plus the maximum time the instrument (1, 2) takes to complete a current scan, plus the maximum time it takes for the mirror (33, 32) to slew to the star. When the satellite is first placed in orbit, and following first stationkeeping and eclipse, a special operation is performed in which the star-seeking instrument (1, 2) FOV is broadened. The elevation dimension can be broadened by performing repetitive star seeks; the azimuth dimension can be broadened by lengthening the commanded dwell times

Comet and close approach asteroid mission study final report

Comet and close approach asteroid mission

Satellite camera image navigation

Pixels within a satellite camera (1, 2) image are precisely located in terms of latitude and longitude on a celestial body, such as the earth, being imaged. A computer (60) on the earth generates models (40, 50) of the satellite's orbit and attitude, respectively. The orbit model (40) is generated from measurements of stars and landmarks taken by the camera (1, 2), and by range data. The orbit model (40) is an expression of the satellite's latitude and longitude at the subsatellite point, and of the altitude of the satellite, as a function of time, using as coefficients (K) the six Keplerian elements at epoch. The attitude model (50) is based upon star measurements taken by each camera (1, 2). The attitude model (50) is a set of expressions for the deviations in a set of mutually orthogonal reference optical axes (x, y, z) as a function of time, for each camera (1, 2). Measured data is fit into the models (40, 50) using a walking least squares fit algorithm. A transformation computer (66 ) transforms pixel coordinates as telemetered by the camera (1, 2) into earth latitude and longitude coordinates, using the orbit and attitude models (40, 50)

Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer.

BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 international consensus guidelines ("Fukuoka criteria").MethodsRetrospective case series involving patients referred for endoscopic ultrasound (EUS) of indeterminate pancreatic cysts with clinical and EUS features consistent with BD-IPMN. Rates of pancreatic cancer occurring at any location in the pancreas were compared between groups of patients with one or more Fukuoka criteria ("Highest-Risk Group", HRG) and those without these criteria ("Lowest-Risk Group", LRG).ResultsAfter exclusions, 661 patients comprised the final cohort (250 HRG and 411 LRG patients), 62% female with an average age of 67 years and 4 years of follow up. Pancreatic cancer, primarily adenocarcinoma, occurred in 60 patients (59 HRG, 1 LRG). Prevalent cancers diagnosed during EUS, immediate surgery, or first year of follow up were found in 48/661 (7.3%) of cohort and exclusively in HRG (33/77, 42.3%). Using Kaplan-Meier method, the cumulative incidence of cancer at 7 years was 28% in HRG and 1.2% in LRG patients (P<0.001).ConclusionsThis study supports using Fukuoka criteria to stratify the immediate and long-term risks of pancreatic cancer in presumptive BD-IPMN. The risk of pancreatic cancer was highest during the first year and occurred exclusively in those with "high-risk stigmata" or "worrisome features" criteria. After the first year all BD-IPMN continued to have a low but persistent cancer risk

Development of an invasively monitored porcine model of acetaminophen-induced acute liver failure

Background: The development of effective therapies for acute liver failure (ALF) is limited by our knowledge of the pathophysiology of this condition, and the lack of suitable large animal models of acetaminophen toxicity. Our aim was to develop a reproducible invasively-monitored porcine model of acetaminophen-induced ALF. Method: 35kg pigs were maintained under general anaesthesia and invasively monitored. Control pigs received a saline infusion, whereas ALF pigs received acetaminophen intravenously for 12 hours to maintain blood concentrations between 200-300 mg/l. Animals surviving 28 hours were euthanased. Results: Cytochrome p450 levels in phenobarbital pre-treated animals were significantly higher than non pre-treated animals (300 vs 100 pmol/mg protein). Control pigs (n=4) survived 28-hour anaesthesia without incident. Of nine pigs that received acetaminophen, four survived 20 hours and two survived 28 hours. Injured animals developed hypotension (mean arterial pressure; 40.8+/-5.9 vs 59+/-2.0 mmHg), increased cardiac output (7.26+/-1.86 vs 3.30+/-0.40 l/min) and decreased systemic vascular resistance (8.48+/-2.75 vs 16.2+/-1.76 mPa/s/m3). Dyspnoea developed as liver injury progressed and the increased pulmonary vascular resistance (636+/-95 vs 301+/-26.9 mPa/s/m3) observed may reflect the development of respiratory distress syndrome. Liver damage was confirmed by deterioration in pH (7.23+/-0.05 vs 7.45+/-0.02) and prothrombin time (36+/-2 vs 8.9+/-0.3 seconds) compared with controls. Factor V and VII levels were reduced to 9.3 and 15.5% of starting values in injured animals. A marked increase in serum AST (471.5+/-210 vs 42+/-8.14) coincided with a marked reduction in serum albumin (11.5+/-1.71 vs 25+/-1 g/dL) in injured animals. Animals displayed evidence of renal impairment; mean creatinine levels 280.2+/-36.5 vs 131.6+/-9.33 mumol/l. Liver histology revealed evidence of severe centrilobular necrosis with coagulative necrosis. Marked renal tubular necrosis was also seen. Methaemoglobin levels did not rise >5%. Intracranial hypertension was not seen (ICP monitoring), but there was biochemical evidence of encephalopathy by the reduction of Fischer's ratio from 5.6 +/- 1.1 to 0.45 +/- 0.06. Conclusion: We have developed a reproducible large animal model of acetaminophen-induced liver failure, which allows in-depth investigation of the pathophysiological basis of this condition. Furthermore, this represents an important large animal model for testing artificial liver support systems