Craniopharyngioma - Transnasal Endoscopic Approach

Craniopharyngiomas are slow growing tumours arising from remnants of the craniopharyngeal duct and occupy the sellar region. The patients may remain asymptomatic for long duration or present with headache or visual disturbances. Surgery is the mainstay of the treatment. Traditionally these tumours have been removed by neurosurgeons through the cranial approach but the advent of nasal endoscopes has opened new avenues for ENT surgeons to treat such patients. We hereby present a case of craniopharyngioma who was successfully treated by Trans-nasal Hypophysectomy

A Rare Nasopharyngeal Foreign Body

Nasopharynx is an exceptionally rare anatomical location for foreign body impaction. We present a rare case of nasopharyngeal foreign body (NFB) in a 7 years old child. The diagnosis was confirmed by nasal endoscopy. Immediate removal of foreign body (FB) in the nasopharynx was performed under general anesthesia. This rare situation is potentially dangerous, since its dislodgment may cause fatal airway obstruction. Therefore, in all cases with missing foreign bodies in the aerodigestive system, nasopharyngeal impaction should be kept in mind and endoscopic examination of the region should be considere

Primary Non-Hodgkin's Malignant Lymphoma of the Sinonasal Tract

Primary non-Hodgkin’s lymphomas (NHL) of the sinonasal tract are rather uncommon entities. Morphologically and radiographically, sinonasal lymphomas are difficult to distinguish from other malignant neoplasms or non- neoplastic processes. They have a variable presentation from fulminant destructive manifestations to chronic indolent type of disease and may mimic as carcinomas and invasive fungal infection respectively. We report a case of primary NHL involving sinonasal tract in elderly female, which was clinically and radiologically mimicking as sinonasal malignany and was proven as NHL on histological examination and confirmed by immunohistochemistry. A high index of suspicion, appropriate histopathological examination and immunohistochemistry is necessary to differentiate sinonasal lymphomas from other possibilities. Failure to do so may miss the diagnosis and delay appropriate treatmen

Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Osseous metastasis in patients of thyroid carcinoma is not very common, and appendicular skeleton is very rare. Bone metastasis represents a complication, especially of follicular thyroid carcinoma and severely reduces the quality of life causing pain, and fractures. Diagnosis is typically done by correlating clinical suspicion with imaging. Occult clinical presentations usually delay the detection and management of patients with bone metastasis from thyroid carcinoma. There is limited information about the clinical presentations and prognosis of patients with follicular thyroid carcinoma with bone metastasis. We hereby present a case report of right arm swelling diagnosed as metastatic carcinoma having metastasis from thyroid primary

Unusual bone metastasis from follicular carcinoma thyroid: presenting as a primary bone malignancy

Osseous metastasis in patients of thyroid carcinoma is not very common, and appendicular skeleton is very rare. Bone metastasis represents a complication, especially of follicular thyroid carcinoma and severely reduces the quality of life causing pain, and fractures. Diagnosis is typically done by correlating clinical suspicion with imaging. Occult clinical presentations usually delay the detection and management of patients with bone metastasis from thyroid carcinoma. There is limited information about the clinical presentations and prognosis of patients with follicular thyroid carcinoma with bone metastasis. We hereby present a case report of right arm swelling diagnosed as metastatic carcinoma having metastasis from thyroid primary.</p

Infoveillance of Mucormycosis in India: A Google™ Trends Based Study

India reported highest incidence of Mucormycosis in the past and during the second wave of COVID-19. Google Trends is a potential tool for infoveillance of infectious disease like Mucormycosis. Relative Search Volume (RSV) for term Mucormycosis (+ Black fungus), diabetes, steroid, oxygen, D-dimer (+ferritin) had been extracted from Google Trends for three months (March to May 2021) and state-wise prevalence for Mucormycosis released by Ministry of Health and Family Welfare was used for the analysis. India reported highest RSV for Mucormycosis among the top five countries with COVID-19 cases. RSV peak for oxygen preceded the Mucormycosis spike. Correlation between state-wise prevalence of Mucormycosis and their corresponding RSV was not significant. While a positive correlation was observed between Mucormycosis, diabetes and steroid, it was not statistically significant. Infoveillance using Google trends can serve as a proxy marker for the public health needs and priorities much before actual field surveys

Learning Transfers over Several Programming Languages

Large language models (LLMs) have recently become remarkably good at improving developer productivity for high-resource programming languages. These models use two kinds of data: large amounts of unlabeled code samples for pretraining and relatively smaller amounts of labeled code samples for fine-tuning or in-context learning. Unfortunately, many programming languages are low-resource, lacking labeled samples for most tasks and often even lacking unlabeled samples. Therefore, users of low-resource languages (e.g., legacy or new languages) miss out on the benefits of LLMs. Cross-lingual transfer learning uses data from a source language to improve model performance on a target language. It has been well-studied for natural languages, but has received little attention for programming languages. This paper reports extensive experiments on four tasks using a transformer-based LLM and 11 to 41 programming languages to explore the following questions. First, how well cross-lingual transfer works for a given task across different language pairs. Second, given a task and target language, how to best choose a source language. Third, the characteristics of a language pair that are predictive of transfer performance, and fourth, how that depends on the given task.Comment: 16 pages, 5 figures, 5 table

The MILLET MISSION: The potential to combat non-communicable diseases and future research opportunities in India

NCD Burden and the role of nutritionChronic diseases, often known as non-communicable diseases (NCDs), pose a significant threat to worldwide public health. As per World Health Organisation (WHO), NCDs account for 74% of all fatalities worldwide, with cardiovascular disease, cancer, respiratory disease, and diabetes being the leading causes.[1] Inadequate nutrition, including diets heavy in sugar, salt, saturated and trans fats, and deficient in fruits, vegetables, whole grains, and lean protein sources, is a significant risk factor for NCDs. The World Health Organization suggests a diet rich in fruits, vegetables, whole grains, nuts, and seeds and low in processed foods, sugar, saturated and trans fats.[2