2-(4-Bromo­phen­yl)-2-oxoethyl anthracene-9-carboxyl­ate

In the title compound, C23H15BrO3, the anthracene ring system is essentially planar [maximum deviation = 0.29 (2) Å] and makes a dihedral angle of 5.74 (8)° with the mean plane of the bromo-substituted benzene ring. An intra­molecular C—H⋯O hydrogen bond generates an S(9) ring motif. In the crystal, mol­ecules are linked by C—H⋯O inter­actions, forming a two-dimensional network parallel to the ac plane. π–π stacking inter­actions are observed between benzene rings [centroid–centroid distances = 3.5949 (14) and 3.5960 (13) Å]

Synthesis And Characterization Of Graphene Oxide –Polyoxometalate Composite Material For Device Applications

Polyoxometalates (POMs) consisting of clusters of d-block transition metals and oxygen atoms represent an important class of water soluble polynuclear nanomaterial. The tuneable size, structure and elemental composition of POM draws considerable attention for the development of functional composite materials of desired chemical and electronic properties.[1] Graphene can be the promising support for POMs due to its low band gap energy and fast electron transport properties. These properties of grapheme facilitates transport of electrons of POMs rapidly and effectively.[2] In the present investigation, graphene oxide (GO) and reduced graphene oxide (rGO) have been used as a support for POM-graphene composites for semiconductor, hydrogen production applications.[2] The deposition of POM on graphene oxide sheets were carried out through electron transfer interaction and electrostatic interaction between POM and GO sheets. ...

2-(4-Fluoro­phen­yl)-2-oxoethyl 4-meth­oxy­benzoate

In the title compound, C16H13FO4, the dihedral angle between the benzene rings is 84.28 (8)°. In the crystal, C—H⋯F and C—H⋯O hydrogen bonds link the mol­ecules to form a three-dimensional network. The crystal structure is consolidated by C—H⋯π inter­actions and short F⋯F contacts [2.7748 (14) Å] also occur

Ethyl 4-(4′-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate Prevents Progression of Monocrotaline-induced Pulmonary Arterial Hypertension in Rats

Therapies to prevent onset and progression of pulmonary arterial pressure are not very effective yet. This study was designed to investigate the effects of a novel dihydropyrimidinone, ethyl 4-(4′-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate (H-DHPM) on pathogenesis of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). For the same purpose, rats were injected intraperitoneally (i.p.) a single dose (60 mg/kg) of MCT which led to development of PAH in 21 days. MCT insult caused high mortality, pulmonary vascular and parenchymal remodelling. Since the course of PAH pathogenesis is characterised by an early onset and progression phases, H-DHPM was administered i.p. at 30 mg/kg dosage in MCT pre-injected animals either from day 0 through day 21 or day 14 though day 21 of MCT injection in two separate treatment groups. H-DHPM significantly improved survival, prevented remodelling of pulmonary vasculature and parenchyma and subsequently ameliorated PAH pathogenesis. Moreover, we observed significant decrease in right ventricle hypertrophy, measured by wet weight of right ventricle (RV) divided by wet weight of left ventricle plus septum (LV+S), in H-DHPM treated groups as compared to MCT injected animals. These findings suggest H-DHPM not only prevented development of PAH but also treated the PAH pathogenesis in progressive phase. In conclusion, our data determines H-DHPM, might be a future drug for the prevention of PAH

2-(4-Chloro­phen­yl)-2-oxoethyl 2,4-di­fluoro­benzoate

The asymmetric unit of title compound, C15H9ClF2O3, consists of two crystallographically independent mol­ecules. The dihedral angle between the two terminal benzene rings in one mol­ecule is 7.92 (14)°, while that in the other mol­ecule is 73.50 (16)°. In the crystal, mol­ecules are stacked into columns along the b axis by inter­molecular C—H⋯O hydrogen bonds. A π–π inter­action with a centroid-to-centroid distance of 3.747 (2) Å further stabilizes the crystal structure

2-(4-Bromo­phen­yl)-2-oxoethyl 4-methyl­benzoate

The title compound, C16H13BrO3, consists of a toluene ring and a bromo­benzene ring which are linked together by a 2-oxopropyl acetate group. The dihedral angle formed between the toluene and bromo­benzene rings is 80.70 (7)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional network

2-(4-Chloro­phen­yl)-2-oxoethyl 2-meth­oxy­benzoate

In the title compound, C16H13ClO4, the two benzene rings make a dihedral angle of 86.38 (8)°. In the crystal, inter­molecular C—H⋯O hydrogen bonds link the mol­ecules to form columns along the a axis. The mol­ecules are also stabilized by a π–π stacking inter­action, with a centroid–centroid distance of 3.7793 (10) Å between the inversion-related benzene rings

2-(4-Bromo­phen­yl)-2-oxoethyl 2-meth­oxy­benzoate

In the title mol­ecule, C16H13BrO4, the dihedral angle between the benzene rings is 85.92 (10)°. In the crystal, mol­ecules are linked into chains along [100] via weak inter­molecular C—H⋯O hydrogen bonds

2-(4-Bromo­phen­yl)-2-oxoethyl 4-meth­oxy­benzoate

In the title compound, C16H13BrO4, the benzene rings are almost perpendicular to each other, making a dihedral angle of 84.07 (8)°. In the crystal, the mol­ecules are linked into chains along the a axis via inter­molecular C—H⋯O hydrogen bonds. A C—H⋯π inter­action is also observed

2-(4-Bromo­phen­yl)-2-oxoethyl 2-methyl­benzoate

In the title compound, C16H13BrO3, the dihedral angle formed between the bromo- and methyl-substituted benzene rings is 66.66 (8)°. In the crystal, mol­ecules are linked by inter­molecular C—H⋯O hydrogen bonds, forming a two-dimensional network parallel to the ac plane. The crystal packing is further consolidated by C—H⋯π inter­actions