ABSTRACT CCR4 is selectively expressed on Th2-type CD4+ T-cells, which play a pivotal role in driving the allergic inflammation response . CCR4 antagonists are used for the treatment of allergic inflammation .Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening ,The lead optimization has been carried out by Quantitative Structure Activity Relationship(QSAR) studies .The biological activity is found to be linearly related to QlogP and σi 