Capacity Loss From Localization Error in MIMO Channel Using Leaky Coaxial Cable

Leaky coaxial (LCX) cable has been employed as antennas for wireless traffic over many linear-cell scenarios such as railway station, tunnels and shopping malls. In addition, LCX can be used for user localization and wireless power transfer (WPT). Compared with the equal power allocation method, the power allocation method for LCX system using positional information (PI) can improve its capacity with the same level of computational complexity. In this paper, we will investigate the level of capacity loss on the 2.4 GHz and 5 GHz band for the conventional equal power (EP) allocation method, the water-filling (WF) based power allocation, and our proposed low-complexity power allocation method for LCX system with PI. The results show that LCX system with our proposed method using PI can reduce the capacity loss due to localization error than that of others

Two-Dimensional RSSI-Based Indoor Localization Using Multiple Leaky Coaxial Cables With a Probabilistic Neural Network

Received signal strength indicator (RSSI) based indoor localization technology has its irreplaceable advantages for many location-aware applications. It is becoming obvious that in the development of fifth-generation (5G) and future communication technology, indoor localization technology will play a key role in location-based application scenarios including smart home systems, manufacturing automation, health care, and robotics. Compared with wireless coverage using conventional monopole antenna, leaky coaxial cables (LCX) can generate a uniform and stable wireless coverage over a long-narrow linear-cell or irregular environment such as railway station and underground shopping-mall, especially for some manufacturing factories with wireless zone areas from a large number of mental machines. This paper presents a localization method using multiple leaky coaxial cables (LCX) for an indoor multipath-rich environment. Different from conventional localization methods based on time of arrival (TOA) or time difference of arrival (TDOA), we consider improving the localization accuracy by machine learning RSSI from LCX. We will present a probabilistic neural network (PNN) approach by utilizing RSSI from LCX. The proposal is aimed at the two-dimensional (2-D) localization in a trajectory. In addition, we also compared the performance of the RSSI-based PNN (RSSI-PNN) method and conventional TDOA method over the same environment. The results show the RSSI-PNN method is promising and more than 90% of the localization errors in the RSSI-PNN method are within 1 m. Compared with the conventional TDOA method, the RSSI-PNN method has better localization performance especially in the middle area of the wireless coverage of LCXs in the indoor environment

Lymphocytes in tumor-draining lymph nodes co-cultured with autologous tumor cells for adoptive cell therapy

Background: Tumor-draining lymph nodes (TDLNs) are primary sites, where anti-tumor lymphocytes are primed to tumor-specific antigens and play pivotal roles in immune responses against tumors. Although adoptive cell therapy (ACT) using lymphocytes isolated from TDLNs were reported, characterization of immune activity of lymphocytes in TDLNs to tumor cells was not comprehensively performed. Here, we demonstrate TDLNs to have very high potential as cell sources for immunotherapy. Methods: Lymphocytes from TDLNs resected during surgical operation were cultured with autologous-tumor cells for 2 weeks and evaluated tumor-reactivity by IFNγ ELISPOT assay. We investigated the commonality of T cell receptor (TCR) clonotypes expanded by the co-culture with tumor cells with those of tumor infiltrating lymphocytes (TILs). Results: We found that that TCR clonotypes of PD-1-expressing CD8+ T cells in lymph nodes commonly shared with those of TILs in primary tumors and lymphocytes having tumor-reactivity and TCR clonotypes shared with TILs could be induced from non-metastatic lymph nodes when they were co-cultured with autologous tumor cells. Conclusion: Our results imply that tumor-reactive effector T cells were present even in pathologically non-metastatic lymph nodes and could be expanded in vitro in the presence of autologous tumor cells and possibly be applied for ACT

FZD10-targeted α-radioimmunotherapy with 225Ac-labeled OTSA101 achieves complete remission in a synovial sarcoma model

Synovial sarcomas are rare tumors arising in adolescents and young adults. The prognosis for advanced disease is poor, with an overall survival of 12-18 months. Frizzled homolog 10 (FZD10) is overexpressed in most synovial sarcomas, making it a promising therapeutic target. The results of a phase 1 trial of β-radioimmunotherapy (RIT) with the 90Y-labeled anti-FZD10 antibody OTSA101 revealed a need for improved efficacy. The present study evaluated the potential of α-RIT with OTSA101 labeled with the α-emitter 225Ac. Competitive inhibition and cell binding assays showed that specific binding of 225Ac-labeled OTSA101 to SYO-1 synovial sarcoma cells was comparable to that of the imaging agent 111In-labeled OTSA101. Biodistribution studies showed high uptake in SYO-1 tumors and low uptake in normal organs, except for blood. Dosimetric studies showed that the biologically effective dose (BED) of 225Ac-labeled OTSA101 for tumors was 7.8 Bd higher than that of 90Y-labeled OTSA101. 90Y- and 225Ac-labeled OTSA101 decreased tumor volume and prolonged survival. 225Ac-labeled OTSA101 achieved a complete response in 60% of mice, and no recurrence was observed. 225Ac-labeled OTSA101 induced a larger amount of necrosis and apoptosis than 90Y-labeled OTSA101, although the cell proliferation decrease was comparable. The BED for normal organs and tissues was tolerable; no treatment-related mortality or obvious toxicity, except for temporary body weight loss, was observed. 225Ac-labeled OTSA101 provided a high BED for tumors and achieved a 60% complete response in the synovial sarcoma mouse model SYO-1. RIT with 225Ac-labeled OTSA101 is a promising therapeutic option for synovial sarcoma

Bifurcation of self-motion depending on the reaction order

As a simple example of an autonomous motor, the characteristic features of self-motion coupled with the acid-base reaction were numerically and experimentally investigated at the air/aqueous interface. Oscillatory and uniform motion were categorized as a function of the reaction order by numerical computations using a mathematical model that incorporates both the distribution of the surface active layer developed from a material particle as the driving force and the kinetics of the acid-base reaction. The nature of the self-motion was experimentally observed for a boat adhered to a camphor derivative with a mono- or di-carboxylic acid on a phosphate aqueous phase as the base. © the Owner Societies

The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis

SummaryBackground/ObjectiveThe significance of extended lymphadenectomy for colorectal cancer with extraregional lymph node metastasis, such as para-aortic lymph node metastasis, has not been established. The purpose of this study was to evaluate the significance of extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis.MethodsBetween July 2004 and December 2013, 16 patients with synchronous extraregional lymph node metastasis without other organ metastases underwent curative resection and extended lymphadenectomy (R0 group). The clinical characteristics and survival outcomes of the R0 group were compared with those of 12 patients with extraregional lymph node metastasis who underwent palliative surgery (control group).ResultsIn the R0 group, the 5-year cancer-specific survival (CSS) rate was 70.3% and the 5-year relapse-free survival (RFS) rate was 60.5%. The 5-year CSS differed significantly between the R0 and control groups (70.3% vs. 12.5%; p = 0.0003). Univariate analyses revealed that the total numbers of metastatic lymph nodes and metastatic regional lymph nodes present were significantly associated with RFS (p = 0.019 for both).ConclusionFindings from our study suggest that extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis might be effective in carefully selected patients