Fluctuation Analysis of the Non-abelian Born-Infeld Action in Background Intersecting D-branes

{We carry out a fluctuation analysis of the non-abelian Born-Infeld action up to order F^6 in the presence of a background intersecting D-branes system. We compare the mass spectrum which is obtained in our analysis to the spectrum derived from the worldsheet analysis. The mass spectra completely agree with each other. This result provides a strong support for the claim that the action we analyze here, which was proposed in hep-th/0208044 by Koerber and Sevrin, is the correct low energy effective action of string theory.Comment: 16 pages, PTP style. reference added, minor correction

Green-Schwarz superstring from type IIB matrix model

We construct Green-Schwarz (GS) light-cone closed superstring theory from type IIB matrix model. A GS light-cone string action is derived from two dimensional N=8 U(n) noncommutative Yang-Mills (NCYM) by identifying noncommutative scale with string scale. Supersymmetry transformation for the light-cone gauge action is also derived from supersymmetry transformation for IIB matrix model. By identifying the physical states and interaction vertices, string theory is perturbatively reproduced.Comment: 5 pages, 3 figures, minor revision

Graviton Propagators in Supergravity and Noncommutative Gauge Theory

We investigate the graviton propagator in the type IIB supergravity background which is dual to 4 dimensional noncommutative gauge theory. We assume that the boundary is located not at the infinity but at the noncommutative scale where the string frame metric exhibits the maximum. We argue that the Neumann boundary condition is the appropriate boundary condition to be adopted at the boundary. We find that the graviton propagator behaves just as that of the 4 dimensional massless graviton. On the other hand, the non-analytic behaviors of the other Kaluza-Klein modes are not significantly affected by the Neumann boundary condition.Comment: 19 page

Important roles of odontoblast membrane phospholipids in early dentin mineralization

The objective of this study was to first identify the timing and location of early mineralization of mouse first molar, and subsequently, to characterize the nucleation site for mineral formation in dentin from a materials science viewpoint and evaluate the effect of environmental cues (pH) affecting early dentin formation. Early dentin mineralization in mouse first molars began in the buccal central cusp on post-natal day 0 (P0), and was first hypothesized to involve collagen fibers. However, elemental mapping indicated the co-localization of phospholipids with collagen fibers in the early mineralization area. Co-localization of phosphatidylserine and annexin V, a functional protein that binds to plasma membrane phospholipids, indicated that phospholipids in the pre-dentin matrix were derived from the plasma membrane. A 3-dimensional in vitro biomimetic mineralization assay confirmed that phospholipids from the plasma membrane are critical factors initiating mineralization. Additionally, the direct measurement of the tooth germ pH, indicated it to be alkaline. The alkaline environment markedly enhanced the mineralization of cell membrane phospholipids. These results indicate that cell membrane phospholipids are nucleation sites for mineral formation, and could be important materials for bottom-up approaches aiming for rapid and more complex fabrication of dentin-like structures

Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective

Bone regeneration was one of the earliest fields to develop in the context of tissue regeneration, and currently, repair of small-sized bone defects has reached a high success rate. Future researches are expected to incorporate more advanced techniques toward achieving rapid bone repair and modulation of the regenerated bone quality. For these purposes, it is important to have a more integrative understanding of the mechanisms of bone formation and maturation from multiple perspectives and to incorporate these new concepts into the development and designing of novel materials and techniques for bone regeneration. This review focuses on the analysis of the earliest stages of bone tissue development from the biology, material science, and engineering perspectives for a more integrative understanding of bone formation and maturation, and for the development of novel biology-based engineering approaches for tissue synthesis in vitro. More specifically, the authors describe the systematic methodology that allowed the understanding of the different nucleation sites in intramembranous and endochondral ossification, the space-making process for mineral formation and growth, as well as the process of apatite crystal cluster growth in vivo in the presence of suppressing biomolecules. A detailed understanding of the developmental process of bone tissue leads to the acquisition of useful information for the bone tissue fabrication. This review summarizes the study of the calcification process of the calvaria and epiphyses from an engineering perspective and provides useful information for the realization of bone tissue biofabrication. Here, we describe the new mechanism of space formation for mineralization such as rupture of chondrocytes and disruption of cell-cell adhesion. We also describe the roles of nucleation site such as cell membrane nanofragments and matrix vesicles.Hara E.S., Okada M., Nagaoka N., et al. Re-Evaluation of Initial Bone Mineralization from an Engineering Perspective. Tissue Engineering - Part B: Reviews, 28, 1, 246. https://doi.org/10.1089/ten.teb.2020.0352

Graviton Propagators on Fuzzy G/H

We describe closed string modes by open Wilson lines in noncommutative (NC) gauge theories on compact fuzzy G/H in IIB matrix model. In this construction the world sheet cut-off is related to the spacetime cut-off since the string bit of the symmetric traced Wilson line carries the minimum momentum on G/H. We show that the two point correlation functions of graviton type Wilson lines in 4 dimensional NC gauge theories behave as 1/(momentum)^2. This result suggests that graviton is localized on D3-brane, so we can naturally interpret D3-branes as our universe. Our result is not limited to D3-brane system, and we generalize our analysis to other dimensions and even to any topology of D-brane worldvolume within fuzzy G/H.Comment: 22 pages, 1 figure. minor correction

Three-dimensional observation and analysis of remineralization in dentinal caries lesions

The remineralization mechanism in dental caries lesions is not completely understood. This study reports on ultrastructural and chemical changes observed within arrested caries lesions. Carious human teeth were observed using scanning electron microscopy (SEM) and focused-ion-beam (FIB)-SEM. The crystals detected in the caries lesions were characterized by transmission electron microscopy (TEM), along with chemical element mapping using energy-dispersive spectroscopy (EDS)-STEM. FIB-SEM 3D reconstructions revealed a severely damaged dentin surface abundantly covered by bacteria. Although the dentin tubules were clogged up to a depth of 100 mu m, bacterial invasion into dentin tubules was not observed. TEM crystal analysis and EDS-STEM revealed the presence of Ca and P, as well as of Mg within the HAp crystals deposited inside the dentin tubules. It was concluded that extensive remineralization with deposition of Mg-HAp crystals had occurred in dentin tubules of caries-arrested dentin. Understanding the natural remineralization process is thought to be helpful for developing clinical biomimetic remineralization protocols