Sublingual Misoprostol for Unsatisfactory Colposcopic Finding: A randomized controlled trial

Objectives: To assess the effectiveness of 200 μg sublingual misoprostol for converting an unsatisfactory to satisfactory colposcopic finding.Materials and Methods: Forty-two participants with abnormal cervical cytology and unsatisfactory colposcopic finding who underwent colposcopy between September 2016 and June 2017 were randomized into two groups; either misoprostol or placebo given sublingually. Second colposcopy was performed 2 hours later, and the conversion rate of unsatisfactory to satisfactory colposcopic finding of both groups was analyzed.Results: Baseline characteristics were similar between two groups. Conversion rate of unsatisfactory to satisfactory colposcopic finding in participants who received sublingual misoprostol was statistically significant higher than placebo group (80.9% vs 38.1%, p = 0.011, relative risk = 2.1, 95% confidence interval 1.18-3.80). There was no significant difference in adverse effect between groups.Conclusion: Two hundred micrograms of sublingual misoprostol, 2 hours before performing colposcopy can convert an unsatisfactory finding to a satisfactory one