4 research outputs found
Effectiveness of adjusting for heterogeneity of variance in genetic evaluation of Japanese Black cattle
The use of link provider data to improve national genetic evaluation across weakly connected subpopulations1
Clinical Efficacy of Thrombus Aspiration on 5-Year Clinical Outcomes in Patients With ST-Segment Elevation Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Background: Adjunctive thrombus aspiration (TA) during primary percutaneous coronary intervention (PCI) was reported to promote better coronary and myocardial reperfusion. However, longâterm mortality benefit of TA remains controversial. The objective of this study is to investigate the clinical impact of TA on longâterm clinical outcomes in patients with STâsegment elevation myocardial infarction (STEMI) undergoing primary PCI. Methods and Results: The CREDOâKyoto AMI Registry is a largeâscale cohort study of acute myocardial infarction patients undergoing coronary revascularization in 2005â2007 at 26 hospitals in Japan. Among 5429 patients enrolled in the registry, the current study population consisted of 3536 patients who arrived at the hospital within 12 hours after the symptom onset and underwent primary PCI. Clinical outcomes were compared between the 2 patient groups with or without TA. During primary PCI procedures, 2239 out of 3536 (63%) patients underwent TA (TA group). The cumulative 5âyear incidence of allâcause death was significantly lower in the TA group than in the nonâTA group (18.5% versus 23.9%, logârank P<0.001). After adjusting for confounders, however, the risk for allâcause death in the TA group was not significantly lower than that in the nonâTA group (hazard ratio: 0.90, 95% CI: 0.76 to 1.06, P=0.21). The adjusted risks for cardiac death, myocardial infarction, stroke, and targetâlesion revascularization were also not significantly different between the 2 groups. Conclusions: Adjunctive TA during primary PCI was not associated with better 5âyear mortality in STEMI patients