Calibration of a Hybrid Machine Tool from the Point of View of Positioning Accuracy

The development of machine tools in the last twenty years includes, among other things, the application of mechanisms with a non-linear kinematic structure as the mechanical basis of machines. This results in significant improvements in kinematic characteristics and problems related to non-linear dependencies of the accuracy of the drive elements and the realization of movement in the machine’s external coordinates. The paper presents an approach to machine tool calibration based on the original O-X glide mechanism based on the ISO 230-4 standard with the mono- and bi-directional compensation of systematic errors and adaptation to the specifics of the mechanism’s kinematics. A machine tool prototype was designed and built for the research presented in the paper. The obtained results indicate the possibility of applying the existing recommendations and standards for testing the accuracy of machine tools with the need to correct the methodology by using linear and non-linear kinematic structures in machine tools

Incidence and clinical relevance of T(11;19) translocation in salivary gland mucoepidermoid carcinoma

Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene disrupts normal cell-cycle and differentiation, contributing to tumor development. The objectives of this study were to establish the incidence of CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC of salivary glands were tested for the presence of CRTC1-MAML2 fusion using reverse transcriptase-polymerase chain reaction. Clinicopathological parameters and survival data were examined in relation to fusion status. The CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was associated exclusively with low-intermediate grade tumor histology (P = 0.02) and favorable clinical outcome, with 100 % overall survival rate (P=0.046). The study has shown that the presence of the CRTC1-MAML2 fusion can serve as an additional diagnostic and prognostic marker for mucoepidermoid carcinomas