Pseudogaucher cells obscuring multiple myeloma: a case report

Gaucher-like or pseudo-Gaucher cells have been noted in a variety of conditions including acute lymphoblastic leukemia, Hodgkin's disease, thalassemia, and multiple myeloma. They have an eccentric, lobulated nucleus, foamy cytoplasm but lack the tubular inclusions seen in Gaucher cells. The pseudo-Gaucher cells have distinct appearances on electron microscopy which distinguish them from true Gaucher cells

A comparative study of fat transfer with compression therapy versus compression therapy alone in the treatment of hypertrophic burn scars: A prospective randomized trial

Introduction: Hypertrophic scars (HS) remain the main cosmetic concern after complete healing of burns for both patients and treating burn surgeons. HS are managed conservatively using compression therapy, but in our study, we attempt fat grafting with compression therapy to identify which treatment modality leads to better outcomes in patients. Materials and Methods: A total of 84 patients (42 in each arm) in this prospective single-blind randomized controlled study had undergone fat transfer with compression therapy and compression therapy alone at a tertiary care burn center for treatment of HS from July 2015 to June 2017. Results: Out of the total of 84 patients, 54 were male and 30 were female with the mean age being 26.19 and 37.93 years in the case (test) and control group, respectively. Among them, 54 were flame burns and 20 were electrical burns. Mean total body surface area of 23.67% and 44.36% in the case and control, respectively, represents the extent of burns in majority of patients. Assessment of scars was done using the Patient and Observer Scar Assessment Scale which was found statistically significant (<0.005) in both patient and observer assessment in case group, i.e., fat grafting with compression therapy at all times during follow-up. Early complications in form of erythema and swelling in 20 cases, swelling in 13, erythema in 4, and none in 5. Conclusion: Our study suggested the superiority of fat grafting with compression therapy in the improvement of HS. Patients tolerated outpatient procedures well with minimal morbidity and self-limiting complications

Morphological findings in bone marrow biopsy and aspirate smears of visceral kala azar: A review

Context: Visceral leishmaniasis (VL) is endemic in India and may simulate and cause many hematological disorders like pancytopenia, myelofibrosis, myelodysplasia and hemophagocytosis. Aims: The study aims to investigate the hematological manifestation of Visceral Leishmaniasis and associated changes that may be observed in bone marrow aspirate smears and biopsy which may warn a pathologist of possible infections. Settings and Design: This is a retrospective study of 18 VL cases on B (b) one marrow aspirate and biopsy in the department of Pathology in a tertiary care teaching hospital in New Delhi. Methods and Material: Giemsa stained slides of bone marrow aspirates and hematoxylin and Eosin stained biopsy slides were reviewed in detail by two competent pathologists. All the findings were tabulated and discussed and comparisons made with the previous similar studies. Results: Hyper cellular marrow, increased lymphocytes and plasma cells, marrow granulomas, hemophagocytosis, myelofibrosis, myelodysplasia and gelatinous transformation of the marrow were notable features the presence of which together or individually should caution a pathologist to search for Leishman Donovan (LD) bodies in patients especially in a non-endemic zone in a tropical country