Unusual features of scabies complicating human T-lymphotropic virus type III infection

Four cases of “exaggerated” scabies are described in patients who were immunodeficient secondary to human T-lymphotropic virus type III (HTLV-III) infection. As in classical scabies, these patients had a pruritic derrnatitis but lacked the usual distribution of the eruption. The rash was initially misdiagnosed in all four patients. Scabies should be considered in pruritic dermatitis in patients at risk for HTLV-III infection

Complete amino acid sequence of human T-cell leukemia virus structural protein p15

AbstractThe complete amino acid sequence of human T-cell leukemia virus (HTLV) structural protein p15 has been determined. The intact protein and peptides generated by enzymatic digestion and acid cleavage were purified by reversed-phase liquid chromatography and subjected to semi-automated Edman degradation. HTLV p15 is a basic linear polypeptide composed of 85 amino acids with Mr 9458. The primary structure indicates that HTLV p15 is homologous to the nucleic acid binding proteins of other type-C retroviruses and especially related to bovine leukemia virus p12

Concomitant Infection with HTLV-I and HTLV-III in a Patient with T8 Lymphoproliferative Disease

All currently known human retroviruses are T-cell lymphotropic viruses (HTLVs) and primarily infect T 4 cells (reviewed by Wong-Staal and Gallo 1 ). HTLV-I immortalizes normal T lymphocytes in vitro, and in vivo is associated with adult T-cell leukemia/lymphoma 2 3 4 5 as well as other T 4 neoplasms with various clinicopathological names. 6 HTLV-II also transforms T 4 cells, but has been detected only rarely in milder forms of leukemia 7 (and Salahuddin Z, Gallo RC: unpublished data). In contrast, HTLV-III (human immunodeficiency virus) is cytopathic to its target T 4 cell and is the etiologic agent of the acquired immunodeficiency syndrome (AIDS). 8 9 10 11 12 HTLV-IV, more . .