Impact of sea surface height anomalies on cyclone track

Predicting accurate cyclone tracks is crucial for disaster management practices. The unusual westward movement of the 6-11 May 2002 Arabian Sea cyclone has been investigated through community mesoscale National Centre for Atmospheric Research model by giving different sea surface temperatures (SST) in different experiments keeping all other conditions same. In one experiment, we converted sea surface height anomalies (SSHAs) to SST. Oceanic eddies and SSHAs, representing the subsurface thermal structure, played a prominent role in the unusual westward movement of this cyclone. This is the first time that the effect of eddies and SSHAs on cyclone track has been reported

Eribulin mesylate in the treatment of metastatic breast cancer

The treatment of metastatic breast cancer (MBC) has become increasingly challenging as the primary goals of therapy include prolonging life without added toxicity. While multiple agents are approved for the therapy of MBC, there is no standard approach for therapy beyond the second-line. Eribulin mesylate, an analog of the marine sponge halichondrin B, is a non-taxane microtubule dynamics inhibitor with a mechanism of action distinct from other tubulin-targeted drugs. Based on a significant extension in overall survival seen in a Phase III clinical trial, eribulin was approved for third-line therapy in MBC patients following anthracycline and taxane failure. Eribulin has a manageable toxicity profile and a low incidence of peripheral neuropathy. In this review, we discuss the natural source of eribulin, pharmacology, mode of action, preclinical and clinical data, and patient-focused perspectives

Some Fixed point Theorems in Generalization Metric space

In this paper we establish some fixed point results for mapping satisfying sufficient contractive conditions on a complete G-metric space. Key words and phrases: Metric space, generalized metric space

COVID-19 in India: Problems, Challenges and Strategies (Psychological Aspects)

The pandemic COVID-19 is a global challenge which has infected and killed people worldwide. Some people do not show any symptom while some have fever, cough, sore throat, general weakness and fatigue and muscular pain and in most severe cases, severe pneumonia, acute respiratory distress syndrome, sepsis and septic shock all leading to death. It has adversely affected the economy and social integrity of countries. There is rising concern about the mental health challenges of the general population (children, adults, or elderly), along with health workers and family of infected people. This study aims to determine effect of COVID-19 on mental health of people in India. It also focuses on the stigma and discriminating factors in our society and ways to cope with such conditions. A structured survey was conducted with 250 participants of different age groups. Our analysis focuses on the factors affecting mental health of any person, changes in behavior and daily routine due to stress, anxiety or fear of transmission of virus in their family and friends, some are worried for their lifestyle and career. There is a need to understand that pandemic is affecting everyone, either physically or mentally. There must be increase in the study of the aspects of mental health during the pandemic and methods to cope with issues like discrimination for better mental health during pandemic period

(C-f)- Weak Contraction in Cone Metric Spaces

The purpose of this article  is to introduced the concept of  weak contraction in cone metric space and also establish a coincidence and common fixed point result for  weak contractions in cone metric spaces. Our result proper generalizes the results of Sintunavarat and Kumam [7]. We also give an example in support of our result. Keywords :- Cone metric spaces, weak contraction,  weak contraction, coincidence point, common fixed point

Clinico-Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases

Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia. Although known as a distinct entity for a very long time, because of lack of distinct clinical features and morphological criteria, it is difficult to diagnose this variant correctly. We herein present the clinical, morphological, cytochemical, and immunocytochemical features of five cases of AMKL. Certain morphological features such as presence of abnormal platelet count, giant platelets, and cytoplasmic blebbing in blasts were found to be important pointers towards the diagnosis. However, none of the features were found to be consistent and thus morphological diagnosis has to be confirmed by cytochemistry and immunocytochemistry

Caesarean scar pregnancy: a case report with review of management options

Cesarean scar pregnancy is a rare but life-threatening complication. It is the abnormal implantation of gestational sac into myometrium and fibrous scar of previous cesarean section. Its incidence is on rising trend due to increase in rate of cesarean section all over the world. A thirty years old second gravida presented at eight weeks of gestation with complaints of bleeding per vaginum and pain lower abdomen. She was diagnosed as a case of cesarean scar pregnancy (CSP) on ultrasonography and confirmation of diagnosis was done on magnetic resonance imaging. Medical management of scar pregnancy was done successfully with combination of mifepristone and methotrexate. Cesarean scar pregnancy could be catastrophic, if not managed well in time. Management includes both surgical and medical options. Treatment has to be individualized depending on patient’s hemodynamic profile, size of gestational sac, desire for future fertility, compliance for follow up and availability of interventional radiology

From Local Action to Global Policy: A Comparative Policy Content Analysis of National Policies to Address Musculoskeletal Health to Inform Global Policy Development

Background: Global policy to guide action on musculoskeletal (MSK) health is in a nascent phase. Lagging behind other non-communicable diseases (NCDs) there is currently little global policy to assist governments to develop national approaches to MSK health. Considering the importance of comparison and learning for global policy development, we aimed to perform a comparative analysis of national MSK policies to identify areas of innovation and draw common themes and principles that could guide MSK health policy. Methods: Multi-modal search strategy incorporating a systematic online search targeted at the 30 most populated nations; a call to networked experts; a specified question in a related eDelphi questionnaire; and snowballing methods. Extracted data were organised using an a priori framework adapted from the World Health Organization (WHO) Building Blocks and further inductive coding. Subsequently, texts were open coded and thematically analysed to derive specific sub-themes and principles underlying texts within each theme, serving as abstracted, transferable concepts for future global policy. Results: The search yielded 165 documents with 41 retained after removal of duplicates and exclusions. Only three documents were comprehensive national strategies addressing MSK health. The most common conditions addressed in the documents were pain (non-cancer), low back pain, occupational health, inflammatory conditions, and osteoarthritis. Across eight categories, we derived 47 sub-themes with transferable principles that could guide global policy for: service delivery; workforce; medicines and technologies; financing; data and information systems; leadership and governance; citizens, consumers and communities; and research and innovation. Conclusion: There are few examples of national strategic policy to address MSK health; however, many countries are moving towards this by documenting the burden of disease and developing policies for MSK services. This review found a breadth of principles that can add to this existing work and may be adopted to develop comprehensive system-wide MSK health approaches at national and global levels

Following the Science: the role of the academic medical center in the COVID-19 pandemic

This article reviews the experience and role of an academic medical center in a response to the COVID-19 pandemic