Chemically radiative dissipative MHD Casson nanofluid flow on a non-linear elongating stretched sheet with numerous slip and convective boundary conditions

The flow of a Casson nanofluid across a nonlinear stretching surface with a velocity slip and a convective boundary condition is investigated in this work in the magnetohydrodynamic (MHD) domain. This technique emphasizes a variety of effects, including chemical reaction, viscosity dissipation, and velocity ratio. In this study, Brownian motion and thermophoresis are also illustrated. It is assumed that suction exists while a magnetic field is uniform. The governing nonlinear partial differential equations are converted into a set of nonlinear ordinary differential equations using the required similarity transformations, and the Runge-Kutta-Fehlberg fourth-fifth method is then used to solve the system. The updated results are fairly similar to the earlier ones. The graphs and tables examine how various variables affect the speeds, temperatures, concentrations of substances, skin friction values, Sherwood numbers and Nusselt numbers

Performance analysis of DFIG with PI, PID and FOPID control schemes in Micro grid

Doubly Fed Induction Generator (DFIG) is the most popular variable speed wind energy conversion system. Control of the DFIG is more complicated than the control of a standard Induction motor. To control the DFIG, the rotor current is controlled by a power electronics converter. This paper aims to analyze the performance improvement of DFIG with its controllers such as proportional integral, proportional integral derivative and fractional order proportional integral derivative controllers in micro grid. Design and implementation of these controllers are done in the rotor circuit of DFIG byMATLAB simulation tool. The design, analysis, and MATLAB simulation of a constant grid power wind energy conversion system also discussed. In all abnormal conditions, the required reactive power into the grid is taken care by the horizontal axis wind turbine system. Mathematical modeling of DFIG is addressed. Independent control of active and reactive powers isachieved, and different simulation results under loaded conditions, with variation in prime mover speed and Excitation are presented. The simulation results of the proposed system are discussed with the cases such as transient, post transient conditions, variation of wind speed, fluctuation of electromagnetic torque, active and reactive powers, grid voltage and load contribution of DFIG with its controllers in grid. Based on the extensive simulation results, what type of control scheme givesthe effective performance of DFIG in grid is finally concluded. The performances of PID and FOPID controllers are compared with that of PI controller at the end. It is seen that, the closed loop performance of FOPID controller outperforms as compared to conventional controllers

Analysis of Sandwich Composites Using Anova Approach

Abstract--Sandwich construction finds its widespread application in the field of aerospace and consumer domain. Several types of core materials are used in the manufacture of sandwich composites. This paper provides an overview of the effect of foam core thickness and density of sandwich structure subjected to flatwise and edgewise compression followed by flexural test on PU foam based core material. Further ANOVA approach is used to determine the response surface methodology (RSM) of the specimen tested. Central composite design was adopted to study the RSM. The sandwich structure chosen here is made up of glass epoxy type and different density of 80kg/m 3 , 120kg/m 3 and 160kg/m 3 was chosen to study the mechanical properties

Using Foliar Application of Fe and GA3 to Improve Growth of Two Olive cv. (Olea europaea ) Transplants.

This investigation was carried out in the lath house of the nursery of Malta station/ Duhok. Kurdistan region, Iraq. During the growing season of 2017, to study the effect of the different concentrations of  Fe (0, 10 and 20 mg.L -1) and GA3 (0 , 500 and 1000 mg.L-1) on vegetative growth,  roots length  and leaves nutrients content of one year old of  two olive cultivars (Nebali and Bashike) transplantings. The results appear that  Nebali cultivar significantly dominated in stem length (cm), stem diameter(mm),  branch length(cm), leaves number, root length(cm), N(%), K(%), P(%) and Fe(mg.L-1), Baeshike cultivar dominate in leaf area (cm2), stem length(cm) , shoot root ratio(%), root length(cm) and K (%) were significantly increased with the increase the GA3 to 1000 mg.L-1. Foliar application of GA3 at 500 mg.L-1 significantly increased branch length (cm) and P (%). The transplants sprayed with the Fe in 10 mg.L-1 only significantly effect on the Fe % content but spray transplants with the Fe at 20 mg.L-1 had significantly affected on stem diameter(mm), leave number root length(cm) and N(%). Most of the interactions (cultivar × Fe and cultivar × GA3) showed significant effects on the most studied characteristics

EVALUATION OF ACUTE TOXICITY AND ANTI-INFLAMMATORY EFFECTS OF BACCHAROIDES SCHIMPERI (DC.) IN EXPERIMENTAL ANIMALS

Background: Steroidal and non-steroidal anti-inflammatory drugs are most commonly used to treat inflammation, and shown to have severe side effects. In this study, we aimed at evaluating the anti-inflammatory and acute toxicity effects of Baccharoides schimperi (DC.) in order to get new anti-inflammatory agents of natural origin. Materials and methods: The aerial part of the plant was dried under shade, ground and extracted with 96% alcohol (BSE). It was further fractionated in sequence to n-hexane (BSH), chloroform (BSC) and methanol (BSM) soluble fractions. Acute toxicity was evaluated by oral administration of plant and hind paw induced-edema method in rats was used for the anti-inflammatory evaluation. Results: The BSE was found safe up to the dose level of 3 g/kg b.w. and showed LD50 value 7.250 g/kg body weight (b.w.) in mice. BSE showed significant anti-inflammatory effect (62.91%) at 500 mg/kg b.w. Further the n-hexane, chloroform and methanol fractions of BSE were tested for anti-inflammatory activity. The n-hexane fraction (BSH) exhibits significant activity (64.87%) at 400 mg/kg b.w. The methanol fraction (BSM) showed dose dependent activity, highest activity (60.42%) was observed at higher dose 400 of mg/kg b.w. In chloroform fraction (BSC) no significant activity was observed. Conclusion: The results of the study revealed that the plant is safe to the experimental model and recommended as a potential source of anti-inflammatory agent

Tumour Cannabinoid CB1 Receptor and Phosphorylated Epidermal Growth Factor Receptor Expression Are Additive Prognostic Markers for Prostate Cancer

BACKGROUND: In cultured prostate cancer cells, down-regulation of epidermal growth factor receptor (EGFR) has been implicated in mediating the antiproliferative effect of the endogenous cannabinoid (CB) ligand anandamide. Using a well-characterised cohort of prostate cancer patients, we have previously reported that expression levels of phosphorylated EGFR (pEGFR-IR) and CB(1) receptor (CB(1)IR) in tumour tissue at diagnosis are markers of disease-specific survival, but it is not known whether the two markers interact in terms of their influence on disease severity at diagnosis and disease outcome. METHODOLOGY/PRINCIPAL FINDINGS: Data from a cohort of 419 patients who were diagnosed with prostate cancer at transurethral resection for voiding difficulties was used. Scores for both tumour CB(1)IR and pEGFR-IR were available in the database. Of these, 235 had been followed by expectancy until the appearance of metastases. For patients scored for both parameters, Cox proportional-hazards regression analyses using optimal cut-off scores indicated that the two measures provided additional diagnostic information not only to each other, but to that provided by the tumour stage and the Gleason score. When the cases were divided into subgroups on the basis of these cut-off scores, the patients with both CB(1)IR and pEGFR-IR scores above their cut-off had a poorer disease-specific survival and showed a more severe pathology at diagnosis than patients with high pEGFR-IR scores but with CB(1)IR scores below the cut-off. CONCLUSIONS/SIGNIFICANCE: These data indicate that a high tumour CB(1) receptor expression at diagnosis augments the deleterious effects of a high pEGFR expression upon disease-specific survival

“I am not a number!” Opinions and preferences of people with intellectual disability about genetic healthcare

There is limited research exploring the knowledge and experiences of genetic healthcare from the perspective of people with intellectual disability. This study, conducted in New South Wales (Australia), addresses this gap. Eighteen adults with intellectual disability and eight support people were interviewed in this inclusive research study. The transcribed interviews were analysed using inductive content analysis. The findings were discussed in a focus group with ten adults with intellectual disability and in three multi-stakeholder advisory workshops, contributing to the validity and trustworthiness of the findings. Five main themes emerged: (i) access to genetic healthcare services is inequitable, with several barriers to the informed consent process; (ii) the experiences and opinions of people with intellectual disability are variable, including frustration, exclusion and fear; (iii) genetic counselling and diagnoses can be profoundly impactful, but translating a genetic diagnosis into tailored healthcare, appropriate support, peer connections and reproductive planning faces barriers; (iv) people with intellectual disability have a high incidence of exposure to trauma and some reported that their genetic healthcare experiences were associated with further trauma; (v) recommendations for a more respectful and inclusive model of genetic healthcare. Co-designed point-of-care educational and consent resources, accompanied by tailored professional education for healthcare providers, are required to improve the equity and appropriateness of genetic healthcare for people with intellectual disability

COVID-19-Induced Seizures: A Meta-Analysis of Case Series and Retrospective Cohorts

The adverse events and complications of coronavirus disease 2019 (COVID-19) continue to challenge the medical profession despite the worldwide vaccination against the severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19. Other than typical respiratory manifestations, COVID-19 also presents a wide range of neurological manifestations. This article underlines the pooled incidence of COVID-19-induced seizures in patients with epilepsy and without epilepsy. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols, we conducted a bibliographical search, and an initial search revealed 1,375 articles. In total, 21 articles were included in the final analysis by following the inclusion criteria. A total of 11,526 patients from 21 published articles that met the predetermined search criteria were included. The median age of the patients was 61.9 years, of whom 51.5% were males. A total of 255 patients presented with seizures as the first manifestation of COVID-19 with a prevalence of 2.2% (95% confidence interval = 0.05-0.24, p \u3c 0.01) (I2 = 97%), of which 71 patients had previously been diagnosed with epilepsy. Among patients with epilepsy, 49 patients had seizures as an initial presentation of SARA-CoV-2 with an incidence of 72% (0.54-0.85, p = 0.1) (I2 = 34). Although the incidence of COVID-19-induced seizures is not high compared to other neurological manifestations, seizure incidence in epileptic patients with COVID-19 is remarkably high. New-onset seizures in any patient should be considered a presentation of COVID-19 in the absence of other causative factors

REstrictive versus StandarD FlUid Management in Mechanically Ventilated ChildrEn Admitted to PICU: study protocol for a pilot randomised controlled trial (REDUCE-1)

IntroductionIntravenous fluid therapy is the most common intervention in critically ill children. There is an increasing body of evidence questioning the safety of high-volume intravenous fluid administration in these patients. To date, the optimal fluid management strategy remains unclear. We aimed to test the feasibility of a pragmatic randomised controlled trial comparing a restrictive with a standard (liberal) fluid management strategy in critically ill children.Methods and analysisMulticentre, binational pilot, randomised, controlled, open-label, pragmatic trial. Patients <18 years admitted to paediatric intensive care unit and mechanically ventilated at the time of screening are eligible. Patients with tumour lysis syndrome, diabetic ketoacidosis or postorgan transplant are excluded. Interventions: 1:1 random assignment of 154 individual patients into two groups—restrictive versus standard, liberal, fluid strategy—stratified by primary diagnosis (cardiac/non-cardiac). The intervention consists of a restrictive fluid bundle, including lower maintenance fluid allowance, limiting fluid boluses, reducing volumes of drug delivery and initiating diuretics or peritoneal dialysis earlier. The intervention is applied for 48 hours postrandomisation or until discharge (whichever is earlier). Endpoints: The number of patients recruited per month and proportion of recruited to eligible patients are feasibility endpoints. New-onset acute kidney injury and the incidence of clinically relevant central venous thrombosis are safety endpoints. Fluid balance at 48 hours after randomisation is the efficacy endpoint. Survival free of paediatric intensive care censored at 28 days is the clinical endpoint.Ethics and disseminationEthics approval was gained from the Children’s Health Queensland Human Research Ethics Committee (HREC/21/QCHQ/77514, date: 1 September 2021), and University of Zurich (2021-02447, date: 17 March 2023). The trial is registered with the Australia New Zealand Clinical Trials Registry (ACTRN12621001311842). Open-access publication in high impact peer-reviewed journals will be sought. Modern information dissemination strategies will also be used including social media to disseminate the outcomes of the study.Trial registration numberACTRN12621001311842.Protocol version/dateV5/23 May 2023