The rs738409 (I148M) Variant of the PNPLA3 Gene and Type 2 Diabetes in Yakutia

The purpose of our research was to study the association of the PNPLA3 SNP rs738409 (C>G) with type 2 diabetes (T2D) in the Yakuts. The frequency distribution of alleles and genotypes of the PNPLA3 rs738409 SNP was in accordance with HWE. There were no statistically significant differences in the distribution of alleles and genotypes of the PNPLA3 SNP rs738409 (C>G) between T2D patients and non-T2D patients (P>0.05); the G allele and homozygous GG genotype prevailed in both groups. In T2D patients, a high frequency of the G allele (74.1%) was found, with a predominance of the GG genotype (58.5%). We also found that the mutant allele frequency is higher than in the studied populations of the world. Further studies with larger sample size are required to achieve sufficient statistical power to detect the association of the PNPLA3 SNP (rs738409 with the development of T2D in Yakut patients

Influence of Electrophoresis of Antler Mass on Restorative Processes in Young Athletes during the Preparatory Period of a One-Year Training Cycle

We investigated the influence of electrophoresis of antler mass (according to Vermel’s method) on the peripheral blood and indicators of cardiac function in elite athletes during intensive exercise during the preparatory period. This study included 27 male athletes, aged 16-17 years old. Application of electrophoresis of antler mass led to improvement of hemoglobin level and hematocrit, mean corpuscular hemoglobin concentration (MCHC), normalization of hormonal status and myocardial metabolism, and promoted increased fitness and adaptability to physical stress