The association between Metabolic Syndrome and serum levels of lipid peroxidation and interleukin-6 in Gorgan

Background: There are limited studies on the relationship between inflammatory marker such as IL-6 and lipid peroxidation and metabolic syndrome. Objective: The aim of present study was to assess IL-6 and lipid peroxidation in subjects with and without the metabolic syndrome and their association with metabolic syndrome components. Methods: Age and gender matched 40 subjects with metabolic syndrome and 40 control groups took part in this study. Results: The mean malondialdehyde level was significantly higher in overweight and obese subjects with metabolic syndrome than control groups (P. <. 0.05). The mean level of IL-6 in men and the mean level of malondialdehyde in women with metabolic syndrome was significantly higher than control groups (p <. 0.05). There were significant positive correlation between malondialdehyde and fasting blood glucose, triglyceride and systolic blood pressure (p <. 0.05). Conclusions: Our results suggest that higher levels of IL-6 and malondialdehyde may cause insulin resistance and metabolic disorders in all subjects with metabolic syndrome. Malondialdehyde level shows strong association with some metabolic syndrome components. This means the greater risk of metabolic syndrome. © 2015

The association between metabolic syndrome and serum levels of adiponectin and high sensitive C reactive protein in Gorgan

Background: The aim of this study was to assess serum levels of highly sensitive C-reactive protein (hs-CRP) and adiponectin in subjects with metabolic syndrome and control groups. Methods: There were 40 subjects with metabolic syndrome and 40 control groups. Mean serum level of adiponectin and high sensitive C reactive protein were lower and higher in subjects with metabolic syndrome than control groups, respectively. There were significant positive correlation between high sensitive C reactive protein and waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose. There were significant negative correlation between adiponectin and waist circumference and triglyceride. Hs-CRP showed a stronger association with metabolic syndrome than adiponectin. Results: Our findings suggest that elevated hs-CRP and reduced adiponectin showed positive and negative association with some metabolic syndrome components. Hs-CRP showed a stronger association with the metabolic syndrome than adiponectin. Conclusion: It seems that hs-CRP may play a significant role as a risk factor for metabolic syndrome. In this study, in contrast with other findings it may suggest that hs-CRP is more important as a diagnostic biomarker for metabolic syndrome than adiponectin. These differences may be due to the changes in the lifestyle and dietary habits in subjects with metabolic syndrome in Gorgan inhabitants. It likes that these subjects do less physical activity and use more fatty nutrients. It seems that subjects with metabolic syndrome need to change their life style and dietary habits in this area to halt the burden of cardiovascular complications. © 2016 Bentham Science Publishers