Non coding RNA and brain

Small non coding RNAs are a group of very different RNA molecules, present in virtually all cells, with a wide spectrum of regulatory functions which include RNA modification and regulation of protein synthesis. They have been isolated and characterized in all organisms and tissues, from Archaeobacteria to mammals. In mammalian brain there are a number of these small molecules, which are involved in neuronal differentiation as well as, possibly, in learning and memory. In this manuscript, we analyze the present knowledge about the function of the most important groups of small non-coding RNA present in brain: small nucleolar RNAs, small cytoplasmic RNAs, and microRNAs. The last ones, in particular, appear to be critical for dictating neuronal cell identity during development and to play an important role in neurite growth, synaptic development and neuronal plasticity

Cyberdrugs: a cross-sectional study of online pharmacies characteristics

As e-commerce and online pharmacies (OPs) arose, the potential impact of the Internet on the world of health shifted from merely the spread of information to a real opportunity to acquire health services directly. Aim of the study was to investigate the offer of prescription drugs in OPs, analysing their characteristics, using the content analysis method. The research performed using the Google search engine led to an analysis of 118 online pharmacies. Only 51 (43.2%) of them stated their precise location. Ninety-six (81.4%) online pharmacies did not require a medical prescription from the customer's physician. Online pharmacies rise complex issues in terms of patient-doctor relationship, consumer empowerment, drug quality, regulation and public health implication

Мотивационная политика предприятия как основа новой философии управления

В современной концепции управления ключевое место отводится человеку. Именно люди, характеризующиеся не только специальным образованием и профессиональными навыками, но и яркой индивидуальностью, способны генерировать новые идеи и решать непростые задачи в высококонкурентной и динамичной бизнес-среде. Такова закономерность в развитии экономических отношений и совершенствовании менеджмента организаций. Акценты в управлении компанией смещаются к идеологическим (культурным, духовным) ценностям предприятия, носителем которых является его персонал, конкретные сотрудники, способные в этих условиях обеспечивать эффективную работу в высококонкурентной среде

predictive factors of intraocular pressure level evolution over time and glaucoma severity in fuchs heterochromic iridocyclitis

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Explorative Study on the Predictive and Prognostic Value of Early Complete Metabolic Response By FDG-PET–CT During Neoadjuvant Chemotherapy in Patients With Advanced Ovarian Cancer

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Intervención educativa orientada a la conservación de la fauna silvestre del departamento Pocho, provincia de Córdoba, Argentina

Fil: Alperin, Sara E.Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Bruno, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Rosati, Victoria R. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Reati, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.En la actualidad, muchas especies de la fauna silvestre de la provincia de Córdoba presentan severos problemas de conservación por destrucción de hábitat, contaminación y explotación de especies silvestres para caza o mascotismo, entre otras. Ante esta problemática, se encuentra en desarrollo un Programa de Intervención en Educación y Comunicación orientado a la conservación de la biodiversidad, con énfasis en la fauna silvestre del Dpto. Pocho, Córdoba, en la Escuela “General José de San Martín” (primaria), de la localidad de Salsacate.Fil: Alperin, Sara E.Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Bruno, Gabriela. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Rosati, Victoria R. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Fil: Reati, Gustavo. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Centro de Zoología Aplicada; Argentina.Conservación de la Biodiversida

Automated Heuristic Optimization of Prostate VMAT Treatment Planning

Purpose: To investigate a genetic algorithm approach to automatic treatment planning. Methods: A Python script based on genetic algorithm (GA) was implemented for VMAT treatment planning of prostate tumor. The script was implemented in RayStation treatment planning system using Python code. Two different clinical prescriptions were considered: 78 Gy prescribed to planning target volume in 39 fractions (GROUP 1) and simultaneous integrated boost (70.2 Gy to prostate bed and 61.1 Gy to seminal vesicles) in 26 fractions (GROUP 2). The script automatically optimizes doses to PTV and OARs according to GA. A comparison with corresponding plans created with Monaco TPS (M) and Auto-Planning module of Pinnacle3 (AP) was carried out. The plans were evaluated with a total score (TS) of PlanIQ software in terms of target coverage and sparing of OARs as well as clinical score (CS) performed by a Radiation Oncologist. Results: In GROUP 1, mean value of TS were 150.6 ± 30.7, 146.3 ± 36.1 and 137.4 ± 35.7 for AP, GA and M respectively. For GROUP 2, mean value for TS were 163.5 ± 16.8, 163.4 ± 24.7 and 162.9 ± 16.6 for AP, GA and M respectively with no significance differences. In terms of CS, the highest value has been attributed to GA in four patients out of five for both GROUP 1 and 2. Conclusions: Genetic approach is practicable for prostate VMAT plan generation and studies are underway in other anatomical sites such as Head and Neck and Rectum

Smoking Habit Prevention in Schools: Report of a Pediatric Educational Intervention Held in Pisa

Introduction: Smoking is the leading preventable cause of death in the world and the detrimental effects of tobacco on health have been described across the full life span. There is no safe level of tobacco exposure and childhood is the more vulnerable period of life. Current estimates show that 10% of children aged 13-15 years are active smokers and most of them started smoking at ≥11 years of age, due to peer and/or family influence. Moreover, recently, e-cigarette use has spread, particularly among youth. Many school-based smoking prevention interventions have been carried out around the world, the efficacy of which has yet to be established. Materials and methods: In February 2018 we planned an educational program on smoking habit within the Italian Society of Pediatric Respiratory Diseases (SIMRI) (“Dai un calcio al fumo” program). In May 2018 we held 8 interventions at the Fibonacci School (Pisa, Italy), meeting 365 children aged 9 to 13 years and involving a pediatrician and a pediatric resident in a 2-hour lesson focusing on the importance of a healthy lifestyle and smoking habit effects. The children were invited to ask questions and talk about their experiences, with a subsequent 30-minutes collegial discussion. The most frequent questions were collected, as well as students’, physicians’ and teachers’ opinions on each meeting. Results: During our educational interventions the most frequently asked questions were about the discrepancy related to the fact that a dangerous product is legally sold and the potential harmful effects of e-cigarettes. All the children stated that they knew that combustible cigarette smoking was dangerous. Most of them admitted that they feel that smoking habits start from emulating friends and relatives. Almost 70% of the children reported to have at least one smoker relative. Teachers, physicians and students proposed to replicate the meetings the following year. Conclusions: The considerable interest shown by the students, together with the low cost and potential effectiveness of school-based educational measures, suggest that in our country a national educational program should be introduced in schools. Too many children are still exposed to tobacco smoke in the household environment

TRIBUNAL DO JÚRI E SUA CAIXA DE PANDORA: MUDARAM O INQUISIDOR, MAS A FOGUEIRA CONTINUA ACESA

A Constituição da República traça um projeto democrático que inegavelmente condiciona toda construção dogmática e legislativa do Processo Penal brasileiro, que deve ser um instrumento a serviço desse desenho de Estado e sociedade, enquanto mecanismo civilizatório de apuração de responsabilidade. Dessa forma, é imperioso que se entenda o Direito Processual Penal não apenas como um instrumento de aplicação do direito penal, mas, sobretudo, como um instrumental de proteção do débil, que tem por finalidade a máxima eficácia dos direitos fundamentais. Em assim sendo, mister se faz uma releitura crítica da gestão da prova pelo Conselho de Sentença do Tribunal do Júri