Increasing students’ cognitive interest through the integration of disciplines

One of the main features of the updated educational content introduced into the general education system of the Republic of Kazakhstan is the improvement of pedagogical skills of teachers in the use of "interdisciplinary topics" in the classroom. The organization of interdisciplinary communication, in turn, increases the interest in the subject and activates the student’s critical thinking. With the skillful use of interdisciplinary connections, it contributes to the formation of all the functions of teaching: the system of scientific knowledge, generalized cognitive skills, broad cognitive interests, students’ worldviews. Implementation of interdisciplinary connections allows students to see the integrity of the image of the world, a clear understanding of the objectives of education. Therefore, in the article we have considered ways to use interdisciplinary connections in order to increase the cognitive interest of students in Physics lessons, in particular, the use of historical data in Physics lessons. Ways to solve the problem of increasing interest in physics through interdisciplinary communication, taking into account international and domestic experience. According to our research topic, we have analyzed the possibilities of developing students’ cognitive interest in the process of teaching the subject “Methods of teaching Physics” in the educational program 6B01502 – “Physics Teacher Training”. A plan of seminar topics on “Discovery of interdisciplinary links between Physics and History” was prepared, an experimental examination was conducted, quantitative and qualitative differences between control and experimental classes were identified. According to the results of experimental work, an increase in the level of students’ knowledge through the use of interdisciplinary connections in Physics and History was identified during the lesson

Methanol Sensing by a Luminescent Zinc(II)‐Based Metal−Organic Framework

A luminescent zinc-based metal-organic framework (MOF; 1) was synthesized from a highly conjugated tridentate ligand, 1,3,5-tris[(1E)-2′-(4′′-benzoic acid)vinyl]benzene. X-ray single crystal analysis reveals the organization of 1 in a three-dimensional porous framework. Thermogravimetric analysis shows that 1 has a good thermal stability, and resists decomposition up to 420 °C. The removal of the solvent molecules from the cavities leads to a temporary loss of crystallinity, which can be regained by heating the MOF in diethylformamide, the solvent used for the synthesis, as shown by powder X-ray diffraction. In addition, 1 shows luminescent features influenced by the chemical environment, making it suitable as optical sensor. Detection of methanol with a turn-on effect was possible in low concentration in mixtures with water (50 μL/3 mL and 10 μL/3 mL) and as vapor

Methanol Sensing by a Luminescent Zinc(II)-Based Metal−Organic Framework

A luminescent zinc-based metal-organic framework (MOF; 1) was synthesized from a highly conjugated tridentate ligand, 1,3,5-tris[(1E)-2′-(4′′-benzoic acid)vinyl]benzene. X-ray single crystal analysis reveals the organization of 1 in a three-dimensional porous framework. Thermogravimetric analysis shows that 1 has a good thermal stability, and resists decomposition up to 420 °C. The removal of the solvent molecules from the cavities leads to a temporary loss of crystallinity, which can be regained by heating the MOF in diethylformamide, the solvent used for the synthesis, as shown by powder X-ray diffraction. In addition, 1 shows luminescent features influenced by the chemical environment, making it suitable as optical sensor. Detection of methanol with a turn-on effect was possible in low concentration in mixtures with water (50 μL/3 mL and 10 μL/3 mL) and as vapor

Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL

Summary: Platform trials bring the promise of making clinical research more efficient and more patient centric. While their use has become more widespread, including their prominent role during the COVID-19 pandemic response, broader adoption of platform trials has been limited by the lack of experience and tools to navigate the critical upfront planning required to launch such collaborative studies. The European Union-Patient-cEntric clinicAl tRial pLatform (EU-PEARL) initiative has produced new methodologies to expand the use of platform trials with an overarching infrastructure and services embedded into Integrated Research Platforms (IRPs), in collaboration with patient representatives and through consultation with U.S. Food and Drug Administration and European Medicines Agency stakeholders. In this narrative review, we discuss the outlook for platform trials in Europe, including challenges related to infrastructure, design, adaptations, data sharing and regulation. Documents derived from the EU-PEARL project, alongside a literature search including PubMed and relevant grey literature (e.g., guidance from regulatory agencies and health technology agencies) were used as sources for a multi-stage collaborative process through which the 10 more important points based on lessons drawn from the EU-PEARL project were developed and summarised as guidance for the setup of platform trials. We conclude that early involvement of critical stakeholder such as regulatory agencies or patients are critical steps in the implementation and later acceptance of platform trials. Addressing these gaps will be critical for attaining the full potential of platform trials for patients. Funding: Innovative Medicines Initiative 2 Joint Undertaking with support from the European Union’s Horizon 2020 research and innovation programme and EFPIA