Managing Acute Insomnia in Prison: Evaluation of a ‘one-shot’ Cognitive Behavioural Therapy for Insomnia (CBT-I) intervention

Insomnia is a serious condition that affects over 60% of the prison population and has been associated with aggression, anger, impulsivity, suicidality, and increased prison health care use. Nonpharmacological interventions for prison inmates are scarce despite the high prevalence and significant consequences of insomnia among those incarcerated. The aim of the present study was to examine the preliminary efficacy and effectiveness of a one-shot of Cognitive Behavioural Therapy for Insomnia (CBT-I) for prison inmates with acute insomnia in an open trial. The intervention consisted of one 60-70 minute session of CBT-I and a self-management pamphlet. A consecutive series of 30 adult male offenders with acute insomnia from a UK prison completed measures of prospective sleep (daily sleep diary), insomnia symptoms severity (Insomnia Severity Index), and mood symptoms (Patient Health Questionnaire and General Anxiety Disorder) one week before and four weeks after receiving the intervention. Pairwise t-tests revealed that a single-shot of CBT-I was effective in reducing the severity of insomnia in adult male offenders (t=(29), 12.65,p<0.001). Further, the results demonstrated high effect sizes for reductions in depressive (dz=1.07) and anxious (dz=1.06) symptoms, as well as insomnia severity (dz=2.25). A single shot session of CBT-I is effective in managing acute insomnia and mood (depression, anxiety) symptoms in adult male prison inmates. Future research should focus on testing if the single shot CBT-I intervention can be implemented and disseminated in other settings and populations (e.g., female and juvenile/youth offenders)

Sleep Duration, Sleep Quality, and Weapon Carrying in a Sample of Adolescents From Texas

OBJECTIVES: Studies are beginning to document an association between sleep duration and a range of adolescent delinquent behaviors, including weapon carrying. However, little is known about whether and to what extent sleep quality - another dimension of sleep for healthy adolescent functioning - is associated with weapon carrying. We address this gap in knowledge by evaluating the role of restless sleep and sleep duration in adolescent weapon carrying. METHODS: We analyze data from a diverse sample of 994 adolescents from Texas, USA collected in 2010. Multivariate logistic regression models estimate the association of sleep duration and restless sleep on weapon carrying after controlling for theoretical covariates and demographic characteristics. RESULTS: Adolescents sleeping 4 h or less on school nights were more than twice as likely to report carrying a weapon (OR = 2.38, 95% CI = 1.16-4.89, CONCLUSIONS: Our findings align with previous research demonstrating that sleeping 4 or less hours increases the likelihood of adolescent weapon carrying. Restless sleep appears to play less of a role. Future research should elucidate the longitudinal pathways between sleep duration, sleep quality, and forms of adolescent weapon carrying

Interaction of sleep and emotion across the menstrual cycle

Menstruating individuals experience an increased risk for sleep and affective disorders, attributed in part to monthly oscillations in sex hormones. Emotional functioning and sleep continuity worsens during the perimenstrual phase of the menstrual cycle. This study examined the interactive effects of sleep, menstrual phase, and emotion in healthy women. Participants (N = 51, 43% Caucasian) aged 18–35 (m = 24 years) completed actigraphy and daily sleep/emotion diaries over two menstrual cycles (m days = 51.29). Diary and actigraphic total wake time at night (TWT) and daily ratings of positive and negative affect were compared across four phases of the menstrual cycle: perimenstrual, mid-follicular, periovulatory, and mid-luteal. Relationships between phase, sleep, and emotion were estimated using multistep hierarchical linear modelling. Mean menstrual cycle length was 28.61 ± 2.69 days. Perimenstrual phase positively predicted anger (p < 0.001) but no other emotions. Additionally, the perimenstrual phase predicted higher rates of TWT, such that diary TWT was 8–16 min longer during the perimenstrual (m = 67.54, SE = 3.37) compared to other phases (p < 0.001). Actigraphic TWT was also increased by 4–7 min (m = 61.54, SE = 3.37) in the perimenstrual phase (p < 0.001). Positive emotions were 0.05–0.10 points lower (p = 0.006–0.02) when TWT was greater in the perimenstrual phase. Greater rates of anger and sleep disruption were seen during the perimenstrual phase compared with other phases. When poor sleep occurred during the perimenstrual phase individuals reported reduced positive emotions. Reducing perimenstrual sleep disruptions may be an important intervention target for those at risk for affective disorders

Energy or information? The role of seed availability for reproductive decisions in edible dormice

The edible dormouse is a specialized seed predator which is highly adapted to the fluctuations of food availability caused by mast seeding of beech and oak trees. Dormice produce young just in time with maximum food availability, and can completely skip reproduction in years with a lack of seeding. Because their decision to reproduce or not in any particular year is made long before the ripe seeds are available, it seems that dormice can anticipate the upcoming mast situation. We tested the hypothesis that the presence of high caloric food in spring affects their reproductive decision. Therefore, we supplementary fed dormice in a field experiment from spring to early summer with sunflower seeds, which also contain a high amount of energy. Supplemental feeding caused significant increases in the proportion of reproducing females and reproductively active males. These results suggest that edible dormice may use the occurrence of an energy rich food resource to predict the autumnal mast situation. Further, our data indicate that the decision to reproduce was not the result of an increased body mass due to the consumption of surplus food, but that sufficient seed abundance acts as an environmental signal to which dormice adjust their reproduction

Rac1 and Rac3 GTPases Regulate the Development of Hilar Mossy Cells by Affecting the Migration of Their Precursors to the Hilus

We have previously shown that double deletion of the genes for Rac1 and Rac3 GTPases during neuronal development affects late developmental events that perturb the circuitry of the hippocampus, with ensuing epileptic phenotype. These effects include a defect in mossy cells, the major class of excitatory neurons of the hilus. Here, we have addressed the mechanisms that affect the loss of hilar mossy cells in the dorsal hippocampus of mice depleted of the two Rac GTPases. Quantification showed that the loss of mossy cells was evident already at postnatal day 8, soon after these cells become identifiable by a specific marker in the dorsal hilus. Comparative analysis of the hilar region from control and double mutant mice revealed that synaptogenesis was affected in the double mutants, with strongly reduced presynaptic input from dentate granule cells. We found that apoptosis was equally low in the hippocampus of both control and double knockout mice. Labelling with bromodeoxyuridine at embryonic day 12.5 showed no evident difference in the proliferation of neuronal precursors in the hippocampal primordium, while differences in the number of bromodeoxyuridine-labelled cells in the developing hilus revealed a defect in the migration of immature, developing mossy cells in the brain of double knockout mice. Overall, our data show that Rac1 and Rac3 GTPases participate in the normal development of hilar mossy cells, and indicate that they are involved in the regulation of the migration of the mossy cell precursor by preventing their arrival to the dorsal hilus

Association between Sleep Quality and Mental Health among Patients at a Post-COVID-19 Recovery Clinic

A growing body of research documents the persistence of physical and neuropsychiatric symptoms following the resolution of acute COVID-19 infection. To the best of our knowledge, no published study has examined the interaction between insomnia and mental health. Accordingly, we proposed to examine new diagnoses of insomnia, and referrals to pulmonary and sleep medicine clinics for treatment of sleep disorders, in patients presenting to one post-acute COVID-19 recovery clinic. Additionally, we aimed to examine the relationship between poor sleep quality, depression, anxiety, and post-traumatic stress. Patients presented to the clinic on average 2 months following COVID-19 infection; 51.9% (n = 41) were hospitalized, 11.4% (n = 9) were in the intensive care unit, 2.5% (n = 2) were on a mechanical ventilator, and 38.0% (n = 30) were discharged on oxygen. The most commonly reported symptom was fatigue (88%, n = 70), with worse sleep following a COVID-19 infection reported in 50.6% (n = 40). The mean PSQI score was 9.7 (82.3%, n = 65 with poor sleep quality). The mean GAD-7 score was 8.3 (22.8%, n = 14 with severe depression). The mean PHQ-9 was 10.1 (17.8%, n = 18 with severe anxiety). The mean IES-6 was 2.1 (54.4%, n = 43 with post-traumatic stress). Poor sleep quality was significantly associated with increased severity of depression, anxiety, and post-traumatic stress. Future work should follow patients longitudinally to examine if sleep, fatigue, and mental health symptoms improve over time

Cognitive performance of pregnant and postpartum women with and without major depression

Title from first page of PDF file (viewed July 30, 2010)Available free in the San Diego State University Digital Research Collection.Includes bibliographical references (leaves 57-67)Keenan and colleagues (1998) have demonstrated that episodic memory is diminished during pregnancy and returns to baseline in the postpartum period. Given that memory deficits may occur in major depression, possible memory deficits during pregnancy could be exacerbated by major depression. The present study examined memory performance in 37 pregnant women, 14 of whom met clinical criteria for a Major Depressive Episode (MDE) as defined in the Diagnostic and Statistical Manual 4th Edition (DSM-IV), and 23 normal control (NC) pregnant women who had no current or prior history of depression. Additionally, postpartum groups consisted of 21 postpartum women, 11 of whom met clinical criteria for a MDE, and 10 NC postpartum women. The study utilized a 2 x 2 Multivariate Analysis of Variance design to compare memory performance and sleep of pregnant and postpartum women with and without major depression. The study demonstrated that pregnancy and major depression were both associated with poorer performance in a task involving verbal learning and memory. Specifically, on the California Verbal Learning Test (CVLT), pregnant women learned significantly fewer words from trials one through five; recalled significantly fewer words on trial one, short delay free and cued recall, and long delay free and cued recall; and utilized a semantic clustering strategy significantly fewer than postpartum women. Depressed patients learned significantly fewer words from trials one through five, recalled significantly fewer words on CVLT long delay free recall, and utilized a semantic clustering strategy significantly fewer than NC women. No alterations in outcomes of the above analyses were found when age, education, weeks pregnant/postpartum, or circadian preference were applied as covariates. The present results are consistent with previous investigations of memory functioning of major depressive disorder and healthy pregnant and postpartum women. That is, pregnant and depressed women exhited poorer performance in tasks involving verbal learning and memory compared with postpartum and NC women

Sleep and Women’s Health

Sex differences in sleep begin at a very early age and women report poorer sleep quality and have higher risk for insomnia than do men. Sleep may be affected by variation in reproductive hormones, stress, depression, aging, life/role transitions, and other factors. The menstrual cycle is associated with changes in circadian rhythms and sleep architecture. Menstruating women (even without significant menstrual-related complaints) often report poorer sleep quality and greater sleep disturbance during the premenstrual week compared to other times of her menstrual cycle. In addition to these sleep disturbances, women with severe premenstrual syndrome often report more disturbing dreams, sleepiness, fatigue, decreased alertness and concentration during the premenstrual phase. Sleep disturbances are also commonly reported during pregnancy and increase in frequency and duration as the pregnancy progresses. The precipitous decline in hormones and unpredictable sleep patterns of the newborn contribute to and/or exacerbate poor sleep and daytime sleepiness during the early postpartum period. Insomnia is also among the most common health complaints that are reported by perimenopausal women. Women are particularly vulnerable to developing insomnia disorder during these times of reproductive hormonal change. In this review, we present a discussion on the most relevant and recent publications on sleep across the woman’s lifespan, including changes in sleep related to menstruation, pregnancy, postpartum, and the menopausal transition. Treatment for sleep disturbances and insomnia disorder and special considerations for treating women will also be discussed

Sleep duration, sleep quality, and weapon carrying in a sample of adolescents from Texas

Objectives: Studies are beginning to document an association between sleep duration and a range of adolescent delinquent behaviors, including weapon carrying. However, little is known about whether and to what extent sleep quality – another dimension of sleep for healthy adolescent functioning – is associated with weapon carrying. We address this gap in knowledge by evaluating the role of restless sleep and sleep duration in adolescent weapon carrying. Methods: We analyze data from a diverse sample of 994 adolescents from Texas, USA collected in 2010. Multivariate logistic regression models estimate the association of sleep duration and restless sleep on weapon carrying after controlling for theoretical covariates and demographic characteristics. Results: Adolescents sleeping 4 h or less on school nights were more than twice as likely to report carrying a weapon (OR = 2.38, 95% CI = 1.16–4.89, p =.018). Sleeping 5–6 h was associated with higher odds of carrying a weapon, while 6–7 h and 8 or more hours were associated with lower odds; however, all associations were non-significant. Restless sleep was associated with weapon carrying at the bivariate level (Pearson χ2 (3) = 10.56, p =.014), but not at the multivariate (OR = 1.10, 95% CI = 0.91–1.32, p =.299). Conclusions: Our findings align with previous research demonstrating that sleeping 4 or less hours increases the likelihood of adolescent weapon carrying. Restless sleep appears to play less of a role. Future research should elucidate the longitudinal pathways between sleep duration, sleep quality, and forms of adolescent weapon carrying