Streamline and Optimize Population of Your Institutional Repository: Introducing Clarivate\u27s New Profile Enrichment Service Together with Esploro

Your institutional repository is a powerful vehicle for hosting and sharing accumulated knowledge, showcasing your institution’s research, scholarship, and creative works, and earning peer recognition. It can play a critical role in research information management, as well as supporting compliance with open access policies and funder requirements. Populating the repository, even with automated harvesting tools, continues to be a time- and resource-intensive project for library administrators. In this presentation, Technical Solutions Consultant, Sara Branch, will introduce Clarivate’s new Profile Enrichment Service used in combination with the Esploro Repository and Research Information Management solution. This new service can help libraries mitigate the challenge of repository population, along with helping to ensure a comprehensive institutional repository, rich metadata, and if desired, dynamic researcher profiles

Destructive leadership: Causes, consequences and countermeasures

In 2010, David Matsuda, an anthropology professor, was asked to study why almost 30 U.S. soldiers in Iraq had committed or attempted suicide in the past year. His investigation showed that while those soldiers often had major problems in their personal lives, the victims also had in common at least one leader (sometimes a couple of leaders) who made their lives hell. While the evidence did not show that the soldiers’ leaders directly caused them to commit or attempt suicide, it did support the notion that the leaders who had made their lives hell had helped to push them over the brink. It was this finding that forced the U.S. military to confront the problem of “toxic” leadership in the army.Full Tex

Committed to Oprah, Homer, or House: Using the Investment Model to Understand Parasocial Relationships

People can develop close relationships with media figures viewed on TV. Across two studies we examined the extent to which satisfaction with, alternatives to, and investments in such parasocial relationships (PSR) account for feelings of commitment toward favored TV characters. In Study 1, satisfaction and investments positively predicted commitment to fictional TV characters, whereas the alternative of not following any TV character negatively predicted commitment to the PSR. In Study 2, we tested the bases of the investment model as predictors of commitment to fictional (e.g., Homer Simpson) versus nonfictional (e.g., Oprah Winfrey) TV characters. As in Study 1, for both fictional and nonfictional characters, commitment level was significantly predicted by levels of satisfaction and investments. However, the alternative of not following any character was significantly associated with commitment only for fictional characters. Results support the use of the investment model to understand processes underlying PSRs

Person-Thing Orientation as a Predictor of Engineering Persistence and Success

Interest, especially in the United States, is an important motivation for students in choosing a major and the strength of their commitment to remaining in that major. In the examination of engineering students’ reasons for persistence and success, interest has not received an in-depth treatment. Interest as a motivational factor can be characterized and operationalized in several ways. Engineering is often typified as a discipline that primarily deals with the creation and manipulation of man-made artefacts as opposed to a discipline centered on interpersonal interaction. For this study interest has been characterized along the Person-Thing dimension.This has been operationalized as a differential orientation to persons, distinguished by an interest in interpersonal interactions, and an orientation to things, distinguished by a desire for mastery over objects.The participants in this study are entering their fourth, and for many their final year of college.This study is a follow up to a study conducted when the participants were first-year engineering students. The initial study questioned students on their differential orientation to persons or things and about their intention to remain in engineering. That study found that engineering students tend to be higher in thing orientation than person orientation, and those students expressing a stronger orientation towards things showed more interest in continuing engineering beyond the first year, while students expressing a weaker orientation towards things more commonly expressed a desire to leave engineering. These findings were even stronger when only female students were considered.The follow up study, to be reported in this paper, explores the stability of these person-thing traits across this group of students to determine whether it is a stable part of their disposition, or whether it has changed over the course of their college education. The study also examines the success of the person-thing orientation measure in predicting students’ persistence and success in engineering. This research uses a survey administered electronically to students who were in that class of first-year engineers. Data collection is ongoing and is expected to be completed within the next two months. Approximately 500 students are expected to participate in the study. The survey questions students about whether they have since left engineering, or have remained in engineering and intend to graduate with an engineering degree. The survey also questions students as to their plans after completing college, their performance in their major, and measures their current orientation to persons and things.The survey is expected to yield profiles of students’ differential orientation to persons and things.Multivariate analysis of variance will be used to analyze the data and determine whether students’ orientations are stable or whether they changed as a result of their college experience.The predictive power of person-thing orientation to ascertain students’ persistence and success in engineering will also be determined

Scoping review of practice-focused resources to support the implementation of place-based approaches

Issue Addressed There is increasing interest across public health research, policy, and practice in place‐based approaches to improve health outcomes. Practice‐focused resources, such as grey literature, courses and websites, are utilised by practitioners to support the implementation of place‐based approaches. Methods A detailed search of two search engines: Google and DuckDuckGo to identify free practice‐focused resources was conducted. Results Forty‐one resources met inclusion criteria, including 26 publications, 13 web‐based resources and two courses. They were mainly focused on collaboration, developed by not‐for‐profit organisations, focused on a broad target audience, and supported people living with disadvantage. The publications we reviewed generally: clearly stated important information, such as the author of the publication; used their own evaluations, professional experience and other grey literature as supporting evidence; included specific, practical implementation strategies; and were easy to read. Conclusions Based on findings, we recommend that: (1) the development of resources to support evidence‐informed practice and governance be prioritised; (2) resources clearly state their target audience and tailor communication to this audience; (3) resources draw on evidence from a range of sources; (4) resources continue to include practical implementation strategies supported by examples and (5) resource content be adaptable to different contexts (e.g., different settings and/or target populations). So What? This is the first review of practice‐focused resources to support the implementation of place‐based approaches and the findings can be used to reduce duplication of efforts and inform future research, policy, and practice, particularly the refinement of existing resources and the development of future resources

Eating disorder symptoms and weight and shape concerns in a large web-based convenience sample of women ages 50 and above: Results of the gender and body image (GABI) study

Limited research exists on eating disorder symptoms and attitudes and weight and shape concerns in women in mid-life to older adulthood. We conducted an online survey to characterize these behaviors and concerns in women ages 50 and above

Synthetic mycobacterial diacyl trehaloses reveal differential recognition by human T cell receptors and the C-type lectin Mincle

The cell wall of Mycobacterium tuberculosis is composed of diverse glycolipids which potentially interact with the human immune system. To overcome difficulties in obtaining pure compounds from bacterial extracts, we recently synthesized three forms of mycobacterial diacyltrehalose (DAT) that differ in their fatty acid composition, DAT1, DAT2, and DAT3. To study the potential recognition of DATs by human T cells, we treated the lipid-binding antigen presenting molecule CD1b with synthetic DATs and looked for T cells that bound the complex. DAT1- and DAT2-treated CD1b tetramers were recognized by T cells, but DAT3-treated CD1b tetramers were not. A T cell line derived using CD1b-DAT2 tetramers showed that there is no cross-reactivity between DATs in an IFN-γ release assay, suggesting that the chemical structure of the fatty acid at the 3-position determines recognition by T cells. In contrast with the lack of recognition of DAT3 by human T cells, DAT3, but not DAT1 or DAT2, activates Mincle. Thus, we show that the mycobacterial lipid DAT can be both an antigen for T cells and an agonist for the innate Mincle receptor, and that small chemical differences determine recognition by different parts of the immune system

Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians

Abstract: Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will develop active tuberculosis (TB). Approximately half will progress to active TB within the first 18 months after infection, presumably because they fail to mount an effective initial immune response. Here, in a genome-wide genetic study of early TB progression, we genotype 4002 active TB cases and their household contacts in Peru. We quantify genetic heritability (hg2) of early TB progression to be 21.2% (standard error 0.08). This suggests TB progression has a strong genetic basis, and is comparable to traits with well-established genetic bases. We identify a novel association between early TB progression and variants located in a putative enhancer region on chromosome 3q23 (rs73226617, OR = 1.18; P = 3.93 × 10−8). With in silico and in vitro analyses we identify rs73226617 or rs148722713 as the likely functional variant and ATP1B3 as a potential causal target gene with monocyte specific function

A TCR beta-Chain Motif Biases toward Recognition of Human CD1 Proteins

High-throughput TCR sequencing allows interrogation of the human TCR repertoire, potentially connecting TCR sequences to antigenic targets. Unlike the highly polymorphic MHC proteins, monomorphic Ag-presenting molecules such as MR1, CD1d, and CD1b present Ags to T cells with species-wide TCR motifs. CD1b tetramer studies and a survey of the 27 published CD1b-restricted TCRs demonstrated a TCR motif in humans defined by the TCR β-chain variable gene 4-1 (TRBV4-1) region. Unexpectedly, TRBV4-1 was involved in recognition of CD1b regardless of the chemical class of the carried lipid. Crystal structures of two CD1b-specific TRBV4-1+ TCRs show that germline-encoded residues in CDR1 and CDR3 regions of TRBV4-1–encoded sequences interact with each other and consolidate the surface of the TCR. Mutational studies identified a key positively charged residue in TRBV4-1 and a key negatively charged residue in CD1b that is shared with CD1c, which is also recognized by TRBV4-1 TCRs. These data show that one TCR V region can mediate a mechanism of recognition of two related monomorphic Ag-presenting molecules that does not rely on a defined lipid Ag