Synthesis of Functionalized Thiopyrano [2,3-b]quinolines via Cascade Reactions Catalyzed by Magnetic Arginine/Alginate Biocomposite

An effective synthesis of functionalized thiopyrano [2,3-b]quinolines has been described via cascade reactions using super paramagnetic iron oxide nanoparticles (SPIONs) coated with l-arginine (Arg) grafted alginate (Alg), called Fe3O4@Alg@CPTMS@Arg. The reaction was performed between commercially available CH acid compounds such as dimedone or malononitrile, and 2-mercapto-quinoline-3-carbaldehydes under green conditions. This efficient method provides a new route for the formation of functionalized three or four fused rings