Ocular morbidities of premature children with mild or no retinopathy of prematurity

SUMMARY: Küçükevcilioğlu M, Mutlu FM, Sarıcı SÜ. Ocular morbidities of premature children with mild or no retinopathy of prematurity. Turk J Pediatr 2015; 57: 129-135. This study reports the ocular and neurologic outcomes at 3 years of age of preterm children with mild or no retinopathy of prematurity (ROP). We were able to compile data from the medical records of 119 out of 585 (20.3%) children with mild and no ROP, who were screened between March 1999 and March 2012. There were 52 children with mild ROP and 67 with no ROP. In terms of ROP-related risk factors, the mild ROP and no ROP groups showed significant differences in birth weight (p<0.001) and gestational age (p<0.001), as well as in the presence of mechanical ventilation (p=0.04), respiratory distress syndrome (p=0.003), blood transfusion (p=0.006) and sepsis (p=0.024). However, both groups seemed identical in terms of the distribution of refractive errors, presence of strabismus, presence of unfavorable structural or functional outcome, and presence of neurologic sequelae. In particular, the high incidence of neurologic morbidity (100%) in subjects with very poor vision suggested a clear correlation

Familial mediterranean fever with neonatal onset: case report

Familial Mediterranean fever (FMF) is an autosomal recessively inherited disorder characterized by recurrent fever and attacks of abdominal pain, chest pain, and joint pain. Attacks of recurrent fever and serositis are encountered clinically. Attacks may present either with only one symptom or many simultaneous symptoms. Although most of the patients are diagnosed clinically above the age of 2, those cases who are diagnosed before 2 years of age and with clinical course of isolated fever are believed to have a more serious course and tend to develop amyloidosis. In this article, a case who was admitted first on the 22nd day of life and later diagnosed to have FMF with recurrent attacks of isolated fever and no other focus is presented. We emphasize that FMF may present as early as in the first month of life, and it should be considered in cases presenting with fever of unknown origin and misdiagnosed to have late neonatal sepsis or occult bacteremia at this age group

Investigation of the relationship between cord clamping time and risk of hyperbilirubinemia

Background: Although the relationship between umbilical cord clamping time and various parameters such as hemoglobin (Hb) levels, iron deficiency, and risk of neonatal jaundice has previously been studied, to the best of our knowleadge there have been no studies investigating the relationship between cord clamping time and the risk of significant hyperbilirubinemia. We aimed to investigate the relationship between the time of umbilical cord clamping and transcutaneous bilirubin (TcB) measurements made on various postnatal hours, Hb and serum total bilirubin (STB) levels measured on postnatal 4th day, and the risk of development of significant hyperbilirubinemia requiring phototherapy treatment. Methods: Eligible newborns were divided into two groups on the basis of the time of cord clamping: those clamped late (60 seconds or more; Group I) and those clamped early (less than 60 seconds; Group II). Groups were compared with respect to the parameters of cord Hb, postnatal TcB measurements at 6th, 48th, 96th and 168th hours, and 96th hour Hb, STB and direct bilirubin levels. Results: TcB levels at the 96th and 168th hour were significantly higher in Group I when compared to Group II (p < 0.001 and p < 0.001, respectively). The 96th hour STB level was significantly higher in Group I when compared to Group II (p < 0.001). The need of phototherapy requirement was higher in Group I when compared to Group II (p=0.001). Increase in cord blood Hb for each 1 gr/dl caused a 3.94-fold increased risk in the requirement of phototherapy treatment. Cord clamping time showed statistically significant positive correlations with both cord blood and 96th hour venous Hb levels, with both 96th hour and 168th hour TcB levels, and with 96th hour STB levels. Conclusions: Newborns whose cords are clamped late should be followed up closely with respect to high postnatal bilirubin levels and other risks associated with significant hyperbilirubinemia requiring phototherapy treatment

Investigation on malondialdehyde, s100b and advanced oxidation protein product levels in significant hyperbilirubinemia and the effect of intensive phototherapy on these parameter

Background: The parameters of oxidative stress [advanced oxidation protein products (AOPPs), malondialdehyde (MDA), and S100B] and the effect of intensive phototherapy (PT) on these parameters have not been studied extensively in newborns with significant hyperbilirubinemia (SH). We aimed to measure the levels of MDA, S100B, and AOPPs in newborns with SH, and to compare newborns with healthy control newborns without hyperbilirubinemia on the basis of these parameters of oxidative stress. In addition, we investigated the effect of intensive PT on these parameters during the treatment of SH and report our findings for the first time in the literature. Methods: The study was performed in newborns (n = 62) who underwent intensive PT because of SH. Newborns without jaundice constituted the control group (n = 30). Both groups were compared with respect to demographic characteristics and biochemical (laboratory) parameters including MDA, AOPPs, and S100B. MDA, AOPPs, and S100B were also compared before and after intensive PT in the PT group. In the study group, a correlation analysis of demographic characteristics; MDA, AOPP, and S100B values; and changes occurring in MDA, AOPPs, and S100B values due to the effect of intensive PT was performed. Results: Serum total bilirubin, S100B, and MDA levels in the PT group before performing PT were significantly higher than those in the control group. In newborns receiving PT serum total bilirubin, MDA and AOPP levels decreased significantly after intensive PT. In correlation analysis, a statistically significant negative correlation was found only between the amount of billrubin decrease with PT and AOPP levels after PT in the study group. Conclusion: Whether the significant decrease in MDA levels, which was higher prior to PT, is due to the decrease in serum bilirubin levels or due to the effect of intensive PT itself remains to be determined in further studies. The decrease in AOPP levels after PT implies that intensive PT has protective effects on oxidative stress. Copyright (C) 2014, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved

Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: A case report

In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns. The most common minor blood group antigens that cause blood incompatibility between the mother and baby are C, c, E, e, Kell, Duffy, Diego, Kidd and MNSs antigens. In this article, a newborn in whom hyperbilirubinemia due to anti-E minor blood group incompatibility developed and was treated with phototherapy succesfully is presented and minor blood group incompatibilities due to anti-E are reviewed

Acute cyanide poisoning caused by apricot kernel

[No Abstract Available

Human metapneumovirus pneumonia: case report

İlk kez 2001’de tanımlanan human metapnömovirüs (hMPV), 10 yaş altı çocuklarda üst ve alt solunum yolu enfeksiyonlarında izole edilebilen bir virus olsa da ülkemizde bu virusla ilgili olarak yayınlanmış fazla sayıda çalışmaya rastlanmamıştır. Human metapneumovirus tanısında altın standart yöntem RT-PCR yöntemidir. Pnömoni kliniği ve laboratuvar bulguları ile başvuran hastalarda viral/bakteriyel pnömoni ayırıcı tanısında PCR gibi ileri tanı yöntemlerinin hızlı ve etkili bir şekilde kullanılması, hastalara gereksiz antibiyotik tedavisi uygulanmasının önüne geçilmesi ve gerekli durumlarda uygun antiviral tedavinin verilebilmesi açısından önemli katkı sağlayacaktır. Bu makalede solunum sıkıntısı bulguları ve oksijen gereksinimi ile başvuran ve enfeksiyon etkeninin human metapneumovirus olarak tespit edildiği 18 aylık hasta sunulmuş ve 2 yaş altı çocuklarda solunum yolu enfeksiyonlarında klasik solunum yolu viruslarına göre çok daha ender rastlanan ve son yıllarda tanımlanmış bir virus olan human metapnömovirüs ile etken olarak karşılaşılabileceği vurgulanmak istenmiştir

Anti-E ve Rh uygunsuzluğu birlikteliği: immünizasyondan hangisi sorumlu?

The frequency of hemolytic disease of the newborn due to maternal antibodies of subgroup incompatibility other than anti-D (Rh) antibodies has increased in recent years after the common use of anti-D (Rh) immunoglobulins in Rh incompatibilitiy. In this article a newborn who was hospitalized because of jaundice and diagnosed to have E minor blood group incompatibility is presented, and it is emphasized that the underlying etiologic factor may be subgroup incompatibility rather than Rh incompatibility in cases with seemingly Rh-Rh incompatibility who have mild jaundice and a positive direct Coombs test.Son yıllarda Rh uygunsuzluğu nedeni ile Rh (D) immünglobülinlerin yaygın bir biçimde kullanılması sonucunda anti-D dışındaki maternal Ig-G tipi kan grubu antikorların neden olduğu subgrup uyuşmazlığına bağlı yenidoğanın hemolitik hastalığının önemi giderek artmıştır. Bu yazıda yenidoğan döneminde sarılık tanısı ile yatırılan ve anti-E’ye bağlı subgrup uygunsuzluğu tespit edilen bir vaka sunulmuş, görünürde Rh-Rh uygunsuzluğu olan ve hafif sarılıkla giden, direkt Coombs testi pozitif olan vakalarda etiyolojinin Rh uygunsuzluğu olmayabileceği, daha hafif şiddette gidebilen subgrup uygunsuzluğu olabileceği vurgulanmak istenmiştir