4 research outputs found
<i>Hutchinson-Gilford syndrome</i> (progeria)
Progeria is a rare, autosomal dominant, progeroid disorder. In the world literature less than 100 cases have been reported to date. We present this case because of its rarity
A clinical and mycological study of onychomycosis in HIV infection
Background: Onychomycosis is one of the early manifestations of HIV
infection with a prevalence of 15-40%. Multiple nail involvement,
isolation of both common and rare species, and resistance to treatment
are the characteristics of onychomycosis in HIV. Aim: To study the
epidemiology, clinical manifestations of onychomycosis in HIV-infected
individuals and to identify the various causative fungi
microbiologically. Methods: A total of 250 HIV infected patients,
diagnosed by ELISA, were screened for nail involvement; of which 60
patients i.e., 40 males and 20 females, who had clinically suspected
untreated fungal infection were included in this study. Results: Of
the 60 respondents, 34 (56.66%) were from the 31-40 years age group.
Amongst the 40 males, there were 20 manual laborers and 14 farmers;
while 18 of 20 females were housewives. Toenail involvement was seen in
38 patients (63.33%), fingernail in 12 patients (20%) while 10 (16.66%)
patients had involvement of both. Twenty eight (46.66%) patients gave
history of some trauma, 6 (10%) had diabetes mellitus, and only 1
patient (1.66%) had history of peripheral vascular disease. Nineteen
(31.66%) patients had associated tinea pedis, 5 (8.33%) had tinea
manuum, 10 (16.66%) had tinea corporis and 7 (11.66%) had tinea cruris.
Twenty one (35%) respondents had distal and lateral superficial
onychomycosis (DLSO), 5 (8.33%) had proximal subungual onychomycosis
(PSO), 1 (1.66%) had superficial white onychomycosis (SWO), while 33
(55%) had total dystrophic onychomycosis (TDO). Fungal elements were
demonstrated by KOH mount in 49 patients (81.66%) and growth was seen
in 32 (53.33%) cultures. Dermatophytes were isolated in 13 (21.66%) and
nondermatophytic molds (NDM) in 19 (31.66%). Out of the 13 positive
dermatophyte cultures, Trichophyton rubrum was isolated on 11 and
Trichophyton mentagrophytes on 2 cultures. Of the 19 non-dermatophytic
cultures, Aspergillus niger was isolated on 3 and Candida spp. on 12
while Cladosporium spp., Scytalidium hyalinum, Penicillium spp., and
Gymnoascus dankaliensis on 1 each. Conclusions: Total dystrophic
onychomycosis was the most common clinical type and NDM were the
predominant causative organisms
Introduction of Human Immunodeficiency Virus Type 2 Infection in the Philippines
The aim of this study was to describe and document the first case of human immunodeficiency virus type 2 (HIV-2) in the Philippines by using serological and molecular techniques and to compare the diversity of this strain to that of strains from other countries. With the introduction of HIV-2 into the country and the presence of diversified strains of HIV-1, the use of highly sensitive assays to detect all these strains is recommended