4 research outputs found
Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)
- Author
- Aasly Jan O.
- Ahmad-Annuar Azlina
- Akpalu Albert
- Albin Roger
- Alcalay Roy
- Alvarez Ignacio
- Amod Ferzana
- Amouri Rim
- Anderson Tim J.
- Antar Tarek
- Arboleda Gonzalo
- Atadzhanov Masharip
- Avenali Micol
- Awad Paula Saffie
- Azmin Shahrul
- Baak A. Nazl
- Bale Claire
- Bandres-Ciga Sara
- Bardien Soraya
- Beach Thomas
- Beyer Katrin
- Blauwendraat Cornelis
- Borgohain Rupam
- Brice Alexis
- Bustamante Maria Leonor
- Camargos Sarah
- Carr Jonathan
- Carroll Camille
- Casey Bradford
- Chahine Lana M.
- Chan Germaine Hiu-Fai
- Chan Phillip
- Chan Piu
- Chana Pedro
- Chen Honglei
- Cheung Nelson Yuk-Fai
- Chowdhury Sohini
- Comart Charisse
- Cornejo-Olivas Mario
- Corvol Jean-Christophe
- Cruchaga Carlos
- Cubo Esther
- Dadiotis Efthymios
- Dagklis Ioannis
- Dean Marissa
- del Rio Marlene Jimenez
- Dey Sumit
- Doquenia Maria Leila
- Dumanis Sonya
- El-Sadig Sarah
- Ellis Melina
- Ertan Sibel
- Espay Alberto
- Faghri Faraz
- Fang Zih-Hua
- Fiske Brian
- Fon Edward A.
- Fon Ted
- Foo Jia Nee
- Foroud Tatiana
- Funayama Manabu
- Galleguillos Benjamin Pizarro
- Gasser Thomas
- Gatto Emilia M.
- Genc Gencer
- Groppa Sergiu
- Grosset Donald
- Guo Jifeng
- Hadjigorgiou Georgios
- Hall Deborah
- Hardy John
- Hattori Nobutaka
- Hernandez Alvaro
- Hernandez Dena
- Hernandez Dena G.
- Hoenicka Janet
- Hopfner Franziska
- Houlden Henry
- Hunter Julie
- Höglinger Günter
- Iakovenko Elena
- Ibanez Laura
- Illarionova Anastasia
- Inca-Martinez Miguel
- Ip Nancy
- Iwaki Hirotaka
- Jankovic Joseph
- Jasaitye Simona
- Jasaityte Simona
- Jeon Beomseok
- Jonas Cabell
- Joubert Julie
- Junker Johanna
- Kaishibayeva Gulnaz
- Kaiyrzhanov Rauan
- Kamel Walaa A.
- Karimova Altynay
- Kauffman Marcelo
- Khachatryan Samson
- Kieburtz Karl
- Kim Jonggeol Jeff
- Kim Yun Joong
- Kishore Asha
- Klein Christine
- Koks Sulev
- Koretsky Mathew
- KP Divya
- Krack Paul
- Krüger Rejko
- Kuhl Maggie
- Kukkle Prashanth Lingappa
- Kumar Kishore
- Kung Pin-Jui
- Lange Lara M.
- Leonard Hampton
- Levine Kristin
- Levine Kristin S.
- Lewis Patrick Alfryn
- Lim Shen-Yang
- Lin Chin-Hsien
- Lohmann Katja
- Louie Naomi
- Love Seth
- Lubbe Steven
- Luo Wei
- Madoev Harutyun
- Makarious Mary B.
- Marek Kenneth
- Markopoulou Katerina
- Marsili Luca
- Martinez-Carrasco Alejandro
- Martinez-Ramirez Daniel
- Mata Ignacio F.
- Medina Alex
- Mencacci Niccolò Emanuele
- Miranda Marcelo
- Mohamed Wael
- Mok Kin Ying
- Mollenhauer Brit
- Monchi Oury
- Morris Huw R.
- Mubarak Bashayer Al
- Murad Nor Azian Abdul
- Murphy Kaileigh
- Nalls Mike A.
- Nguyen Duan
- Nguyen Toan
- Norlinah Mohamed Ibrahim
- Noyce Alastair
- Nuytemans Karen
- O'Grady Alyssa
- Obese Vida
- Ojha Rajeev
- Ojo Oluwadamilola
- Okubadejo Njideka
- Okunoye Olaitan
- Olguin Patricio
- Orozco Jorge
- Pal Pramod
- Pantazis Caroline B.
- Parnetti Lucilla
- Pastor Pau
- Periñan Maria Teresa
- Pihlstrøm Lasse
- Pitcher Toni L.
- Puckelwartz Megan J.
- Quattrone Andrea
- Rajan Roopa
- Rentería Miguel E.
- Reyes-Pérez Paula
- Richer Madeleine
- Rieder Carlos
- Riley Ekemini
- Rizig Mie
- Rodriguez-Violante Mayela
- Rosales Raymond
- Ruffrage Lauren
- Salama Mohamed
- Salari Mehri
- Sanyaolu Arinola
- Sarmiento Ignacio Juan Keller
- Sassi Samia Ben
- Schapira Anthony
- Schirinzi Tommaso
- Schrag Anette
- Schumacher-Schuh Artur F.
- Screven Laurel
- Screven Laurel A.
- Serrano Geidy E.
- Shambetova Cholpon
- Shang Huifang
- Sharma Manu
- Shepherd Claire E.
- Sherer Todd
- Shiamim Ejaz
- Shiraishi Tomotaka
- Shulman Joshua
- Shulman Lisa
- Siddiqi Bernadette
- Singleton Andrew B.
- Sobering Andrew K.
- Solle Justin
- Solle Justin C.
- Song Yeajin
- Stafford Eleanor J.
- Stamelou Maria
- Stefanis Leonidas
- Stott Simon
- Tan Ai Huey
- Tan Eng-King
- Tan Manuela
- Tan Manuela M. X.
- Tang Beisha
- Tarnanas Ioannis
- Tavadyan Zaruhi
- Tay Yi Wen
- Towns Clodagh
- Trinh Joanne
- Tserensodnom Bayasgalan
- Tumas Vitor
- Umair Muhammad
- Ur-Rehman Shoaib
- Valente Enza Maria
- Vinuela Angel
- Vitale Dan
- Vollstedt Eva-Juliane
- Walker Ruth
- Wegel Claire
- Wegel Claire E.
- Weil Rimona
- Westenberger Ana
- Williams Nigel
- Williamson Jared
- Wood Nicholas
- Wu Hsiu-Chuan
- Wu Ruey-Meei
- Wu Yihru
- Xie Tao
- Xiromerisiou Georgia
- Zewde Yared Z.
- Zhou Xiaopu
- Zimprich Alexander
- Zweier Christiane
- Çakmak Özgür Öztop
- Publication venue
- Publication date
- 12/09/2023
- Field of study
The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia
Multi-ancestry genome-wide association meta-analysis of Parkinson?s disease
- Author
- Aasly Jan O.
- Ahmad-Annuar Azlina
- Akpalu Albert
- Albin Roger
- Alcalay Roy
- Alvarez Ignacio
- Amod Ferzana
- Amouri Rim
- Anderson Tim J.
- Arboleda Gonzalo
- Aslibekyan Stella
- Atadzhanov Masharip
- Auton Adam
- Avenali Micol
- Awad Paula Saffie
- Azmin Shahrul
- Baak A. Nazl
- Babalola Elizabeth
- Bale Claire
- Bandres-Ciga Sara
- Bardien Soraya
- Beach Thomas
- Bell Robert K.
- Beyer Katrin
- Bielenberg Jessica
- Blauwendraat Cornelis
- Borgohain Rupam
- Brice Alexis
- Brolin Kajsa
- Bryc Katarzyna
- Bullis Emily
- Bustamante Maria Leonor
- Camargos Sarah
- Cannon Paul
- Carr Jonathan
- Carroll Camille
- Casey Bradford
- Chahine Lana M.
- Chan Germaine Hiu-Fai
- Chan Phillip
- Chan Piu
- Chana Pedro
- Chen Honglei
- Cheung Nelson Yuk-Fai
- Chowdhury Sohini
- Coker Daniella
- Comart Charisse
- Cornejo-Olivas Mario
- Corvol Jean-Christophe
- Cruchaga Carlos
- Cubo Esther
- Dadiotis Efthymios
- Dagklis Ioannis
- Das Sayantan
- Dean Marissa
- del Rio Marlene Jimenez
- Dey Sumit
- Dhamija Devika
- Divya K. P.
- Doquenia Maria Leila
- Dumanis Sonya
- El-Sadig Sarah
- Ellis Melina
- Elson Sarah L.
- Eriksson Nicholas
- Ertan Sibel
- Espay Alberto
- Faghri Faraz
- Fang Zih-Hua
- Filshtein Teresa
- Fiske Brian
- Fitch Alison
- Fletez-Brant Kipper
- Fon Edward A.
- Fon Ted
- Fontanillas Pierre
- Foo Jia Nee
- Foroud Tatiana
- Freyman Will
- Funayama Manabu
- Galleguillos Benjamin Pizarro
- Gasser Thomas
- Gatto Emilia M.
- Genc Gencer
- Granka Julie M.
- Groppa Sergiu
- Grosset Donald
- Guo Jifeng
- Hadjigorgiou Georgios
- Hall Deborah
- Hardy John
- Hattori Nobutaka
- Heilbron Karl
- Hernandez Alejandro
- Hernandez Alvaro
- Hernandez Dena
- Hicks Barry
- Hinds David A.
- Hoenicka Janet
- Hopfner Franziska
- Houlden Henry
- Hunter Julie
- Höglinger Günter
- Iakovenko Elena
- Ibanez Laura
- Illarionova Anastasia
- Inca-Martinez Miguel
- Ip Nancy
- Iwaki Hirotaka
- Jankovic Joseph
- Jasaityte Simona
- Jeon Beomseok
- Jewett Ethan M.
- Jiang Yunxuan
- Jonas Cabell
- Junker Johanna
- Kaishibayeva Gulnaz
- Kaiyrzhanov Rauan
- Kamel Walaa A.
- Karimova Altynay
- Kauffman Marcelo
- Khachatryan Samson
- Kieburtz Karl
- Kim Jonggeol Jeffrey
- Kim Yun Joong
- Kishore Asha
- Klein Christine
- Koks Sulev
- Koretsky Mathew
- Krack Paul
- Krüger Rejko
- Kuhl Maggie
- Kukar Katelyn
- Kukkle Prashanth Lingappa
- Kumar Kishore
- Kung Pin-Jui
- Kwong Alan
- Lake Julie
- Lange Lara M.
- Leonard Hampton
- Levine Kristin S.
- Lewis Patrick Alfryn
- Lian Michelle Mulan
- Lim Shen-Yang
- Lin Chin-Hsien
- Lin Keng-Han
- Llamas Bianca A.
- Lohmann Katja
- Louie Naomi
- Love Seth
- Lowe Maya
- Lubbe Steven
- Luo Wei
- Madoev Harutyun
- Makarious Mary B.
- Marek Kenneth
- Markopoulou Katerina
- Marsili Luca
- Martinez-Ramirez Daniel
- Martínez-Carrasco Alejandro
- Mata Ignacio
- Mata Ignacio F.
- McCreight Jey C.
- McIntyre Matthew H.
- Medina Alex
- Mencacci Niccolò Emanuele
- Micheletti Steven J.
- Miranda Marcelo
- Mohamed Wael
- Mok Kin Ying
- Mollenhauer Brit
- Monchi Oury
- Moreno Meghan E.
- Morris Huw R.
- Mubarak Bashayer Al
- Murad Nor Azian Abdul
- Murphy Kaileigh
- Nalls Mike A.
- Nandakumar Priyanka
- Nguyen Dominique T.
- Nguyen Duan
- Nguyen Toan
- Noblin Elizabeth S.
- Norlinah Mohamed Ibrahim
- Noyce Alastair J.
- Nuytemans Karen
- O'Connell Jared
- O'Grady Alyssa
- Obese Vida
- Ojha Rajeev
- Ojo Oluwadamilola
- Okubadejo Njideka
- Okunoye Olaitan
- Olguin Patricio
- Orozc Jorge
- Otani Diego Véliz
- Pal Pramod
- Pantazis Caroline B.
- Parnetti Lucilla
- Partida Gabriel Cuellar
- Pastor Pau
- Periñan Maria Teresa
- Petrakovitz Aaron A.
- Pihlstrøm Lasse
- Pitcher Toni L.
- Poznik G. David
- Puckelwartz Megan J.
- Quattrone Andrea
- Rajan Roopa
- Rentería Miguel E.
- Reyes-Pérez Paula
- Reynoso Alexandra
- Rieder Carlos
- Riley Ekemini
- Rizig Mie
- Rodriguez-Violante Mayela
- Rosales Raymond
- Ruffrage Lauren
- Salama Mohamed
- Salari Mehri
- Sanyaolu Arinola
- Sarmiento Ignacio Juan Keller
- Sassi Samia Ben
- Schapira Anthony
- Schirinzi Tommaso
- Schloetter Madeleine
- Schrag Anette
- Schumacher Morgan
- Schumacher-Schuh Artur F.
- Screven Laurel
- Serrano Geidy E.
- Shambetova Cholpon
- Shang Huifang
- Sharma Manu
- Shastri Anjali J.
- Shelton Janie F.
- Shepherd Claire E.
- Sherer Todd
- Shi Jingchunzi
- Shiamim Ejaz
- Shiraishi Tomotaka
- Shringarpure Suyash
- Shulman Joshua
- Shulman Lisa
- Siddiqi Bernadette
- Singleton Andrew B.
- Sobering Andrew K.
- Solle Justin C.
- Solsberg Caroline Warly
- Song Yeajin
- Stafford Eleanor J.
- Stamelou Maria
- Stefanis Leonidas
- Stott Simon
- Su Qiaojuan Jane
- Tan Ai Huey
- Tan Eng-King
- Tan Manuela
- Tang Beisha
- Tarnanas Ioannis
- Tat Susana A.
- Tavadyan Zaruhi
- Tay Yi Wen
- Tchakouté Christophe Toukam
- Tinkhauser Gerd
- Tran Vinh
- Trinh Joanne
- Tserensodnom Bayasgalan
- Tumas Vitor
- Tung Joyce Y.
- Umair Muhammad
- Ur-Rehman Shoaib
- Valente Enza Maria
- Veliz-Otani Diego
- Vinuela Angel
- Vitale Dan
- Vollstedt Eva-Juliane
- Walker Ruth
- Wang Wei
- Wang Xin
- Wegel Claire
- Weil Rimona
- Weldon Catherine H.
- Westenberger Ana
- Williams Nigel
- Williamson Jared
- Wilton Peter
- Wong Corinna D.
- Wood Nicholas
- Wu Hsiu-Chuan
- Wu Ruey-Meei
- Wu Yihru
- Xie Tao
- Xiromerisiou Georgia
- Zewde Yared Z.
- Zhou Xiaopu
- Zimprich Alexander
- Zweier Christiane
- Çakmak Özgür Öztop
- Publication venue
- Nature Research
- Publication date
- 31/01/2024
- Field of study
Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations
Warfarin-induced vitamin K deficiency affects spermatogenesis in Sprague-Dawley rats
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2019
- Field of study
Recommended from our members
Elucidating causative gene variants in hereditary Parkinson's disease in the Global Parkinson's Genetics Program (GP2) (vol 9, 100, 2023)
- Author
- Aasly Jan O.
- Ahmad-Annuar Azlina
- Akpalu Albert
- Al Mubarak Bashayer
- Albin Roger
- Alcalay Roy
- Alvarez Ignacio
- Amod Ferzana
- Amouri Rim
- Anderson Tim J.
- Arboleda Gonzalo
- Atadzhanov Masharip
- Avenali Micol
- Avenali Micol
- Awad Paula Saffie
- Azmin Shahrul
- Bale Claire
- Bandres-Ciga Sara
- Bardien Soraya
- Basak A. Nazl
- Beach Thomas
- Ben Sassi Samia
- Beyer Katrin
- Blauwendraat Cornelis
- Blauwendraat Cornelis
- Borgohain Rupam
- Brice Alexis
- Bustamante Maria Leonor
- Cakmak Ozgur Oztop
- Camargos Sarah
- Carr Jonathan
- Carroll Camille
- Casey Bradford
- Chahine Lana M.
- Chan Germaine Hiu-Fai
- Chan Phillip
- Chan Piu
- Chana Pedro
- Chen Honglei
- Cheung Nelson Yuk-Fai
- Chowdhury Sohini
- Comart Charisse
- Cornejo-Olivas Mario
- Corvol Jean-Christophe
- Cruchaga Carlos
- Cubo Esther
- Dadiotis Efthymios
- Dagklis Ioannis
- Dean Marissa
- del Rio Marlene Jimenez
- Dey Sumit
- Doquenia Maria Leila
- Dumanis Sonya
- El-Sadig Sarah
- Ellis Melina
- Ellis Melina
- Ertan Sibel
- Espay Alberto
- Faghri Faraz
- Fang Zih-Hua
- Fang Zih-Hua
- Fiske Brian
- Fon Edward A.
- Fon Ted
- Foo Jia Nee
- Foroud Tatiana
- Funayama Manabu
- Galandra Caterina
- Galleguillos Benjamin Pizarro
- Gasser Thomas
- Gatto Emilia M.
- Genc Gencer
- Global Parkinsons Genetic Program
- Groppa Sergio
- Grosset Donald
- Guo Jifeng
- Hadjigorgiou Georgios
- Hall Deborah
- Hardy John
- Hattori Nobutaka
- Hernandez Alvaro
- Hernandez Dena
- Heutink Peter
- Hoenicka Janet
- Hoglinger Gunter
- Hopfner Franziska
- Houlden Henry
- Hunter Julie
- Iakovenko Elena
- Ibrahim Norlinah Mohamed
- Illarionova Anastasia
- Illarionova Anastasia
- Inca-Martinez Miguel
- Ip Nancy
- Iwaki Hirotaka
- Jankovic Joseph
- Jasaitye Simona
- Jeon Beomseok
- Jonas Cabell
- Junker Johanna
- Junker Johanna
- Kaishibayeva Gulnaz
- Kaiyrzhanov Rauan
- Kamel Walaa A.
- Karimova Altynay
- Kauffman Marcelo
- Khachatryan Samson
- Kieburtz Karl
- Kim Jonggeol Jeff
- Kim Yun Joong
- Kishore Asha
- Klein Christine
- Klein Christine
- Koks Sulev
- Koretsky Mathew
- Kp Divya
- Kruger Rejko
- Kuhl Maggie
- Kukkle Prashanth Lingappa
- Kumar Kishore
- Kumar Kishore R.
- Kung Pin-Jui
- Lange Lara M.
- Lange Lara M.
- Leonard Hampton
- Levine Kristin S.
- Lewis Patrick Alfryn
- Lim Shen-Yang
- Lim Shen-Yang
- Lin Chin-Hsien
- Lohmann Katja
- Lohmann Katja
- Louie Naomi
- Love Seth
- Lubbe Steven
- Luo Wei
- Madoev Harutyun
- Madoev Harutyun
- Makarious Mary B.
- Marek Kenneth
- Markopoulou Katerina
- Marsili Luca
- Martinez-Carrasco Alejandro
- Martinez-Ramirez Daniel
- Mata Ignacio F.
- Medina Alex
- Mencacci Niccolo
- Mencacci Niccolo Emanuele
- Miranda Marcelo
- Mohamed Wael
- Mok Kin Ying
- Mollenhauer Brit
- Monchi Oury
- Morris Huw R.
- Murad Nor Azian Abdul
- Murphy Kaileigh
- Nalls Mike
- Nalls Mike A.
- Nguyen Duan
- Nguyen Toan
- Norlinah Mohamed Ibrahim
- Noyce Alastair
- Nuytemans Karen
- O'Grady Alyssa
- Obese Vida
- Ojha Rajeev
- Ojo Oluwadamilola
- Okubadejo Njideka
- Okunoye Olaitan
- Olguin Patricio
- Orozco Jorge
- Pal Pramod
- Pantazis Caroline B.
- Parnetti Lucilla
- Pastor Pau
- Paul Krack
- Perinan Maria Teresa
- Pihlstrom Lasse
- Pitcher Toni L.
- Quattrone Andrea
- Rajan Roopa
- Renteria Miguel E.
- Reyes-Perez Paula
- Rieder Carlos
- Riley Ekemini
- Rizig Mie
- Rodriguez-Violante Mayela
- Roopnarain Karisha
- Rosales Raymond
- Ruffrage Lauren
- Salama Mohamed
- Salari Mehri
- Sanyaolu Arinola
- Sarmiento Ignacio J. Keller
- Sarmiento Ignacio Juan Keller
- Schapira Anthony
- Schirinzi Tommaso
- Schrag Anette
- Schumacher-Schuh Artur F.
- Screven Laurel
- Serrano Geidy E.
- Shambetova Cholpon
- Shang Huifang
- Sharma Manu
- Shepherd Claire E.
- Sherer Todd
- Shiamim Ejaz
- Shiraishi Tomotaka
- Shulman Joshua
- Shulman Lisa
- Siddiqi Bernadette
- Singleton Andrew
- Singleton Andrew B.
- Sobering Andrew K.
- Solle Justin
- Solle Justin C.
- Song Yeajin
- Stafford Eleanor J.
- Stamelou Maria
- Stefanis Leonidas
- Stott Simon
- Tan Ai Huey
- Tan Ai-Huey
- Tan Eng-King
- Tan Manuela
- Tang Beisha
- Tarnanas Ioannis
- Tavadyan Zaruhi
- Tay Yi Wen
- Trinh Joanne
- Tserensodnom Bayasgalan
- Tumas Vitor
- Umair Muhammad
- Ur-Rehman Shoaib
- Valente Enza Maria
- Valente Enza Maria
- Vinuela Angel
- Vitale Dan
- Vollstedt Eva-Juliane
- Walker Ruth
- Wegel Claire
- Wegel Claire
- Weil Rimona
- Westenberger Ana
- Williams Nigel
- Williamson Jared
- Wood Nicholas
- Wu Hsiu-Chuan
- Wu Ruey-Meei
- Wu Serena
- Wu Yihru
- Xie Tao
- Xiromerisiou Georgia
- Zewde Yared Z.
- Zhou Xiaopu
- Zimprich Alexander
- Zweier Christiane
- Publication venue
- NATURE PORTFOLIO
- Publication date
- 13/09/2023
- Field of study