International migratory agreements: the paradox of adverse interest

This article seeks to explain the contradiction between the promises of welfare gains derived from the economic models recommending the removal of immigration restrictions and the realities experienced by countries attempting to apply restrictions to immigration flows. A formal model is built in which the strategic reaction of countries considers not only the benefits derived from migration but also the (economic and non-economic) costs that migration can generate in the host country. Strategic reactions drive what may be called the “paradox of adverse interest”: the fewer potential gains associated with liberalization of migration, the easier it becomes for nations to reach an unrestrictive agreement. The existence of two asymmetries (between the bargaining power of receiving and sending countries, and between the private nature of most of migration’s benefits and the social nature of its main costs) can hinder the agreement when the countries involved exhibit a high wage differential. Results suggest that permissive international agreements on migration are easier to reach in regional contexts, among countries with proximate economic conditions and levels of income

Technological assimilation and divergence in times of crisis

We study an endogenous stochastic growth model whose dynamic evolution is determined by an adaptive learning process defining the accumulation of technological knowledge within countries. Both the assimilation of technological knowledge and the arrival rate of innovations depend on the technological development level of countries. We illustrate how heterogeneous levels of technological development provide laggard countries with insufficient innovation incentives, leading to divergences in total factor productivity and their technological stagnation. The model is simulated numerically using data from the current Innovation Union Scoreboard where the main expected growth patterns of the Baltic States are compared to those of the reference innovators within the European Union area

R&D internationalization and the strategic relevance of the institutional framework in host locations

The configuration of host national systems of innovation and the technological international networks established by multinational enterprises (MNE) can become key aspects for the internationalisation decision that may also concern knowledge related activities such as R&D. Through the combination of a theoretical model and empirical analysis, this paper shows to what extent institutional quality becomes a determinant factor for the attraction of foreign R&D activities, these latter being conditioned by the technological and productive capabilities of local contexts and the competitive pressures MNE face in foreign countries. Our contribution is a step further in the explanatory framework of R&D internationalisation and also provides new insights about what are the key reinforcement mechanisms for the attraction of new knowledge intensive investments

Innovation dynamics and financial stability: a European Union perspective

We present a formal and empirical framework that links the technological capacity of a country, reflected in its National System of Innovation, with the financial constraints it faces. The paper is divided into two sections. The first one introduces a stochastic growth model based on the relative level of technological development of countries, which determines their productivity and capacity to finance innovation activities. The second section describes the empirical conditioning observed in the innovation outputs of countries determined by their financial constraints and time period relative to the economic crisis of 2008. We classify a panel sample of European Union countries according to their technological development level and find that financial stability constraints negatively affect the less developed ones, a relationship that weakens as their innovation capacity increases. We also observe that financial stability becomes significant among technologically developed countries when reacting to the exogenous shock triggered by the crisis, while laggards remain constrained through the entire 2000–2018 sample period

A Review of Uncertain Decision-Making Methods in Energy Management Using Text Mining and Data Analytics

The managerial and environmental studies conducted in the energy research area reflect its substantial importance, particularly when optimizing and modifying consumption patterns, transitioning to renewable sources away from fossil ones, and designing plans and systems. The aim of this study is to provide a systematic review of the literature allowing us to identify which research subjects have been prioritized in the fields of energy and sustainability in recent years, determine the potential reasons explaining these trends, and categorize the techniques applied to analyze the uncertainty faced by decision-makers. We review articles published in highly ranked journals through the period 2003–2020 and apply text analytics to cluster their main characteristics; that is, we rely on pre-processing and text mining techniques. We analyze the title, abstract, keywords, and research methodology of the articles through clustering and topic modeling and illustrate what methods and fields constitute the main focus of researchers. We demonstrate the substantial importance of fuzzy-related methods and decision-making techniques such as the Analytical Hierarchy Process and Technique for Order Preferences by Similarity to Ideal Solutions (TOPSIS). We also show that subjects such as renewable energy, energy planning, sustainable energy, energy policy, and wind energy have gained relevance among researchers in recent years

An efficient controlled elitism non-dominated sorting genetic algorithm for multi-objective supplier selection under fuzziness

Supplier selection and order allocation constitute vital strategic decisions that must be made by managers within supply chain management environments. In this paper, we propose a multi-objective fuzzy model for supplier selection and order allocation in a two-level supply chain with multi-period, multi-source, and multi-product characteristics. The supplier evaluation objectives considered in this model include cost, delay, and electronic-waste (e-waste) minimization, as well as coverage and weight maximization. A signal function is used to model the price discount offered by the suppliers. Triangular fuzzy numbers are used to deal with the uncertainty of delay and e-waste parameters while the fuzzy Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) is used to obtain the weights of the suppliers. The resulting NP-hard problem, a Pareto-based meta-heuristic algorithm called controlled elitism non-dominated sorting genetic algorithm (CENSGA), is developed. The Non-dominated Sorting Genetic Algorithm (NSGA-II) and Multi-Objective Particle Swarm Optimization (MOPSO) are used to validate the applicability of the CENSGA algorithm and the Taguchi technique to tune the parameters of the algorithms. The results are analysed using graphical and statistical comparisons illustrating how the proposed CENSGA dominates NSGA-II and MOPSO in terms of mean ideal solution distance (MID) and spacing metrics

Postnatal Proteasome Inhibition Induces Neurodegeneration and Cognitive Deficiencies in Adult Mice: A New Model of Neurodevelopment Syndrome

Defects in the ubiquitin-proteasome system have been related to aging and the development of neurodegenerative disease, although the effects of deficient proteasome activity during early postnatal development are poorly understood. Accordingly, we have assessed how proteasome dysfunction during early postnatal development, induced by administering proteasome inhibitors daily during the first 10 days of life, affects the behaviour of adult mice. We found that this regime of exposure to the proteasome inhibitors MG132 or lactacystin did not produce significant behavioural or morphological changes in the first 15 days of life. However, towards the end of the treatment with proteasome inhibitors, there was a loss of mitochondrial markers and activity, and an increase in DNA oxidation. On reaching adulthood, the memory of mice that were injected with proteasome inhibitors postnatally was impaired in hippocampal and amygdala-dependent tasks, and they suffered motor dysfunction and imbalance. These behavioural deficiencies were correlated with neuronal loss in the hippocampus, amygdala and brainstem, and with diminished adult neurogenesis. Accordingly, impairing proteasome activity at early postnatal ages appears to cause morphological and behavioural alterations in adult mice that resemble those associated with certain neurodegenerative diseases and/or syndromes of mental retardation

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research