Perfil clínico-hemodinâmico de pacientes com hipertensão arterial pulmonar e hipertensão pulmonar tromboembólica crônica de um hospital terciário de São Paulo

Objetivo. Descrever as características clínicas e hemodinâmicas dos pacientes com Hipertensão Arterial Pulmonar (HAP) e Hipertensão Pulmonar Tromboembólica Crônica (HPTEC) atendidos no Hospital do Servidor Público Estadual de São Paulo (HSPE). Métodos. Foram revisados os prontuários dos pacientes em seguimento no ambulatório de Circulação Pulmonar do HSPE em acompanhamento entre 2012 e 2019. Hipertensão pulmonar (HP) foi confirmada por cateterismo cardíaco direito e o diagnóstico final de HAP ou HPTEC foi confirmado após avaliação especializada. Resultados. Foram avaliados 46 casos de HP, sendo 31 de HAP e 15 de HPTEC. A média de idade foi de 67,5 (± 10,5) anos, com uma frequência de participantes com idade maior que 60 anos de 73,9%. Houve predomínio do sexo feminino (69,6%). A mediana do tempo de dispneia até o diagnóstico foi de 2 anos. A principal etiologia da HAP foi a esclerose sistêmica e não houve casos de esquistossomose na população estudada. Havia sinais de disfunção do ventrículo direito no momento do diagnóstico em 73,3% dos casos. Entre os pacientes com HPTEC, 46,7% desconheciam evento tromboembólico prévio. Conclusões. Este estudo abordou uma população predominantemente idosa com diagnóstico de HP, destacando as características de dois subtipos da doença. Há necessidade de novos estudos para melhorar o entendimento sobre HP na população brasileira, em especial sobre os portadores de HPTEC.Objective. To describe the clinical and hemodynamic characteristics of patients with Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) treated at the Hospital do Servidor Público Estadual of São Paulo (HSPE). Methods. The medical records of patients under follow-up between 2012 and 2019 at the Pulmonary Circulation ambulatory of HSPE were reviewed. Pulmonary hypertension was confirmed by right cardiac catheterization, as well as the final diagnosis of PAH or CTEPH was confirmed after specialized evaluation. Results. Forty-six cases of pulmonary hypertension were evaluated, 31 of which were PAH and 15 of CTEPH. The mean age overall was 67.5 (± 10,5) years, with a frequency of participants over 60 years of 73,9%. There was a predominance of females (69,6%). The median of dyspnea until diagnosis was 2 years. The main etiology of PAH was systemic sclerosis and there were no cases of schistosomiasis in the studied population. There were signs of right ventricle dysfunction at the time of diagnosis in 73,3% of cases. Among patients with CTEPH, 46,7% were unaware of previous thromboembolic events. Conclusions. This study addressed a predominantly elderly population diagnosed with pulmonary hypertension, highlighting the characteristics of two subtypes of the disease. There is a need for further studies to improve the understanding of PH in the Brazilian population, especially on patients with CTEPH

Câncer de mama e enfrentamento da COVID-19 simultâneos: relato de caso sobre espiritualidade

In this case study, a woman in her sixties had had recent diagnosis of locally advanced breast cancer just in the nick of time COVID-19 pandemic emerged with the first severe cases popping up in Rio de Janeiro State, Brazil. Her close brother had just died of COVID-19 infection and soon after respiratory distress symptoms came up to her. Due to other serious comorbidities, including emphysema, previous stroke, obesity and tabagism, and mechanical ventilation assistance for two weeks, it was also likely she would succumb to COVID-19 and breast cancer, If hadn’t it been for inherent spiritual strength, resilience and faith in God. After Ethical Committee approval, analysis on her speech demonstrated her faith in spiritual treatment, in that she would never stop praying Hail Mary and compared the fact to medical cancer treatment. Altogether with catholic colleagues, she prayed three times a day as a kind of ritual, which ameliorated her grief and depression and influenced positively upon breast cancer and COVID-19 healing.Neste estudo de caso, uma mulher na casa dos sessenta anos teve um diagnóstico recente de câncer de mama localmente avançado bem na hora em que a pandemia de COVID-19 surgiu com os primeiros casos graves no Estado do Rio de Janeiro, Brasil. Seu irmão próximo havia acabado de morrer de infecção por COVID-19 e, logo depois, os sintomas de desconforto respiratório surgiram para ela. Devido a outras comorbidades graves, incluindo enfisema, acidente vascular cerebral anterior, obesidade e tabagismo e assistência de ventilação mecânica por duas semanas, também era provável que ela sucumbisse à COVID-19 e câncer de mama, se não fosse pela força espiritual inerente, resiliência e fé em Deus. Após a aprovação do Comitê de Ética, a análise de sua fala demonstrou sua fé no tratamento espiritual, pois ela nunca deixaria de rezar a Ave Maria e comparou o fato ao tratamento médico do câncer. Junto com colegas católicos, ela rezava três vezes ao dia como uma espécie de ritual, o que amenizava sua dor e depressão e influenciava positivamente na cura do câncer de mama e da COVID-19

Câncer de mama e enfrentamento da COVID-19 simultâneos: relato de caso sobre espiritualidade

In this case study, a woman in her sixties had had recent diagnosis of locally advanced breast cancer just in the nick of time COVID-19 pandemic emerged with the first severe cases popping up in Rio de Janeiro State, Brazil. Her close brother had just died of COVID-19 infection and soon after respiratory distress symptoms came up to her. Due to other serious comorbidities, including emphysema, previous stroke, obesity and tabagism, and mechanical ventilation assistance for two weeks, it was also likely she would succumb to COVID-19 and breast cancer, If hadn’t it been for inherent spiritual strength, resilience and faith in God. After Ethical Committee approval, analysis on her speech demonstrated her faith in spiritual treatment, in that she would never stop praying Hail Mary and compared the fact to medical cancer treatment. Altogether with catholic colleagues, she prayed three times a day as a kind of ritual, which ameliorated her grief and depression and influenced positively upon breast cancer and COVID-19 healing.Neste estudo de caso, uma mulher na casa dos sessenta anos teve um diagnóstico recente de câncer de mama localmente avançado bem na hora em que a pandemia de COVID-19 surgiu com os primeiros casos graves no Estado do Rio de Janeiro, Brasil. Seu irmão próximo havia acabado de morrer de infecção por COVID-19 e, logo depois, os sintomas de desconforto respiratório surgiram para ela. Devido a outras comorbidades graves, incluindo enfisema, acidente vascular cerebral anterior, obesidade e tabagismo e assistência de ventilação mecânica por duas semanas, também era provável que ela sucumbisse à COVID-19 e câncer de mama, se não fosse pela força espiritual inerente, resiliência e fé em Deus. Após a aprovação do Comitê de Ética, a análise de sua fala demonstrou sua fé no tratamento espiritual, pois ela nunca deixaria de rezar a Ave Maria e comparou o fato ao tratamento médico do câncer. Junto com colegas católicos, ela rezava três vezes ao dia como uma espécie de ritual, o que amenizava sua dor e depressão e influenciava positivamente na cura do câncer de mama e da COVID-19

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Assessment of risk scores to predict mortality of COVID-19 patients admitted to the intensive care unit

ObjectivesTo assess the ABC2-SPH score in predicting COVID-19 in-hospital mortality, during intensive care unit (ICU) admission, and to compare its performance with other scores (SOFA, SAPS-3, NEWS2, 4C Mortality Score, SOARS, CURB-65, modified CHA2DS2-VASc, and a novel severity score).Materials and methodsConsecutive patients (≥ 18 years) with laboratory-confirmed COVID-19 admitted to ICUs of 25 hospitals, located in 17 Brazilian cities, from October 2020 to March 2022, were included. Overall performance of the scores was evaluated using the Brier score. ABC2-SPH was used as the reference score, and comparisons between ABC2-SPH and the other scores were performed by using the Bonferroni method of correction. The primary outcome was in-hospital mortality.ResultsABC2-SPH had an area under the curve of 0.716 (95% CI 0.693–0.738), significantly higher than CURB-65, SOFA, NEWS2, SOARS, and modified CHA2DS2-VASc scores. There was no statistically significant difference between ABC2-SPH and SAPS-3, 4C Mortality Score, and the novel severity score.ConclusionABC2-SPH was superior to other risk scores, but it still did not demonstrate an excellent predictive ability for mortality in critically ill COVID-19 patients. Our results indicate the need to develop a new score, for this subset of patients

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements