Spatially uniform calibration of a liquid xenon detector at low energies using 83m-Kr

A difficult task with many particle detectors focusing on interactions below ~100 keV is to perform a calibration in the appropriate energy range that adequately probes all regions of the detector. Because detector response can vary greatly in various locations within the device, a spatially uniform calibration is important. We present a new method for calibration of liquid xenon (LXe) detectors, using the short-lived 83m-Kr. This source has transitions at 9.4 and 32.1 keV, and as a noble gas like Xe, it disperses uniformly in all regions of the detector. Even for low source activities, the existence of the two transitions provides a method of identifying the decays that is free of background. We find that at decreasing energies, the LXe light yield increases, while the amount of electric field quenching is diminished. Additionally, we show that if any long-lived radioactive backgrounds are introduced by this method, they will present less than 67E-6 events/kg/day in the next generation of LXe dark matter direct detection searchesComment: 9 pages, 9 figures. Accepted to Review of Scientific Instrument

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains

The vast majority of our current knowledge about the biochemical and biophysical properties of proteins derives from in vitro studies conducted on isolated globular domains. However, a very large fraction of the proteins expressed in the eukaryotic cell are structurally more complex. In particular, the discovery that up to 40% of the eukaryotic proteins are intrinsically disordered, or possess intrinsically disordered regions, and are highly dynamic entities lacking a well-defined three-dimensional structure, revolutionized the structure–function paradigm and our understanding of proteins. Moreover, proteins are mostly characterized by the presence of multiple domains, in-fluencing each other by intramolecular interactions. Furthermore, proteins exert their function in a crowded intracellular milieu, transiently interacting with a myriad of other macromolecules. In this review we summarize the literature tackling these themes from both the theoretical and experimental perspectives, highlighting the effects on protein folding and function that are played by (i) flanking disordered tails; (ii) contiguous protein domains; (iii) interactions with the cellular environment, defined as quinary structures. We show that, in many cases, both the folding and function of protein domains is remarkably perturbed by the presence of these interactions, pinpointing the importance to increase the level of complexity of the experimental work and to extend the efforts to characterize protein domains in more complex contexts

Identification of a new mtDNA mutation (14724G>A) associated with mitochondrial leukoencephalopathy

Biochem Biophys Res Commun. 2007 Mar 23;354(4):937-41. Epub 2007 Jan 23. Identification of a new mtDNA mutation (14724G>A) associated with mitochondrial leukoencephalopathy. Pereira C, Nogueira C, Barbot C, Tessa A, Soares C, Fattori F, Guimarães A, Santorelli FM, Vilarinho L. Instituto de Genética Médica Jacinto de Magalhães, Praça Pedro Nunes, 88, 4099-028 Porto, Portugal. Abstract We report a novel 14724G>A mutation in the mitochondrial tRNA glutamic acid gene in a 4-year-old boy with myopathy and leukoencephalopathy. A muscle biopsy showed cytochrome c oxidase-negative ragged-red fibers and biochemical analysis of the respiratory chain enzymes in muscle homogenate revealed partial complex I and complex IV deficiencies. The mutation, which affects the dihydrouridine arm at a conserved site, was nearly homoplasmic in muscle and heteroplasmic in blood DNA of the proband, but it was absent in peripheral leukocytes from the asymptomatic mother, sister, and two maternal aunts, suggesting that it arose de novo. This report proposes to look for variants in the mitochondrial genome when dealing with otherwise undetermined leukodystrophies of childhood. PMID: 17266923 [PubMed - indexed for MEDLINE

New Measurement of the Relative Scintillation Efficiency of Xenon Nuclear Recoils Below 10 keV

Liquid xenon is an important detection medium in direct dark matter experiments, which search for low-energy nuclear recoils produced by the elastic scattering of WIMPs with quarks. The two existing measurements of the relative scintillation efficiency of nuclear recoils below 20 keV lead to inconsistent extrapolations at lower energies. This results in a different energy scale and thus sensitivity reach of liquid xenon dark matter detectors. We report a new measurement of the relative scintillation efficiency below 10 keV performed with a liquid xenon scintillation detector, optimized for maximum light collection. Greater than 95% of the interior surface of this detector was instrumented with photomultiplier tubes, giving a scintillation yield of 19.6 photoelectrons/keV electron equivalent for 122 keV gamma rays. We find that the relative scintillation efficiency for nuclear recoils of 5 keV is 0.14, staying constant around this value up to 10 keV. For higher energy recoils we measure a value around 20%, consistent with previously reported data. In light of this new measurement, the XENON10 experiment's results on spin-independent WIMP-nucleon cross section, which were calculated assuming a constant 0.19 relative scintillation efficiency, change from $8.8\times10^{-44}$ cm$^2$ to $9.9\times10^{-44}$ cm$^2$ for WIMPs of mass 100 GeV/c$^2$, and from $4.4\times10^{-44}$ cm$^2$ to $5.6\times10^{-44}$ cm$^2$ for WIMPs of mass 30 GeV/c$^2$.Comment: 8 pages, 8 figure

ArDM: first results from underground commissioning

The Argon Dark Matter experiment is a ton-scale double phase argon Time Projection Chamber designed for direct Dark Matter searches. It combines the detection of scintillation light together with the ionisation charge in order to discriminate the background (electron recoils) from the WIMP signals (nuclear recoils). After a successful operation on surface at CERN, the detector was recently installed in the underground Laboratorio Subterr\'aneo de Canfranc, and the commissioning phase is ongoing. We describe the status of the installation and present first results from data collected underground with the detector filled with gas argon at room temperature.Comment: 6 pages, 3 figures, Light Detection In Noble Elements (LIDINE 2013

WARP: a WIMP double phase Argon detector

The WARP programme for dark matter search with a double phase argon detector is presented. In such a detector both excitation and ionization produced by an impinging particle are evaluated by the contemporary measurement of primary scintillation and secondary (proportional) light signal, this latter being produced by extracting and accelerating ionization electrons in the gas phase. The proposed technique, verified on a 2.3 liters prototype, could be used to efficiently discriminate nuclear recoils, induced by WIMP's interactions, and measure their energy spectrum. An overview of the 2.3 liters results and of the proposed 100 liters detector is shown.Comment: Proceeding for IDM200

Status of the ArDM Experiment: First results from gaseous argon operation in deep underground environment

The Argon Dark Matter (ArDM-1t) experiment is a ton-scale liquid argon (LAr) double-phase time projection chamber designed for direct Dark Matter searches. Such a device allows to explore the low energy frontier in LAr. After successful operation on surface at CERN, the detector has been deployed underground and is presently commissioned at the Canfranc Underground Laboratory (LSC). In this paper, we describe the status of the installation and present first results on data collected in gas phase.Comment: 21 pages, 20 figure