¿Como podemos anallizar la competencia narrativa del alumnado en el aprendizaje de la historia?

The aim of this paper is to analyze the role that teachers assigned to curricular requirements, establishing the relationship between these documents and everyday practice. From the interpretation of interviews with a group of teachers, is to study the ways in which teachers used, discarded and/or reworked curriculum requirements, based on assume that they have an active role in the redefinition of such documents. The research results indicate that the new meanings and adaptations that teachers do in the written standard change according to different courtly and contextual realities

Quest for the donor star in the magnetic precataclysmic variable V1082 Sgr

We obtained high-resolution spectra and multicolor photometry of V1082 Sgr to study the donor star in this 20.8 hr orbital period binary, which is assumed to be a detached system. We measured the rotational velocity (v sin i = 26.5 ± 2.0 km s−1), which, coupled with the constraints on the white dwarf mass from the X-ray spectroscopy, leads to the conclusion that the donor star barely fills 70% of its corresponding Roche lobe radius. It appears to be a slightly evolved K2-type star. This conclusion was further supported by a recently published distance to the binary system measured by the Gaia mission. At the same time, it becomes difficult to explain a very high (>10−9 M⊙ yr-1 ) mass transfer and mass accretion rate in a detached binary via stellar wind and magnetic coupling.Publisher PDFPeer reviewe

Cambios en la vegetación durante el Holoceno reciente en el valle de Lozoya (Sierra de Guadarrama, Madrid)

Se presentan los datos palinológicos procedentes de un testigo obtenido en una formación higroturbosa de origen periglacial situada en el término municipal de Rascafría (Valle del Lozoya, Madrid). El objetivo principal de este trabajo es reconstruir la evolución de la vegetación en el área durante el Holoceno Reciente. Los resultados obtenidos reflejan la existencia de un paisaje vegetal dominado por el estrato herbáceo, constituido fundamentalmente por Cichorioideae, Asteraceae, Chenopodiaceae, Poaceae y Plantago lanceolata. El grupo arbustivo (Erica arborea, Rosaceae, Juniperus y Cistaceae) tiene un papel poco importante en la vegetación; la masa forestal de Pinus sylvestris y en menor proporción P. pinaster y Quercus, junto a presencias de Betula, y Corylus, es poco representativa a lo largo del perfil, excepto hacia el techo de la secuencia, donde muestra un fuerte y progresivo aumento. De los microfósiles no polínicos destacamos la presencia de Pseudoschizaea circula y Glomus, que puede relacionarse con los procesos erosivos in situ favorecidos por fenómenos de sobrepastoreo. Esta información pone de manifiesto la presencia de un paisaje mediterráneo abierto y antropizado, dominado por zonas de pastizal dedicadas al ganado, según se deduce en el diagrama polínico a través de las proporciones de los componentes nitrófilos de carácter zoógeno y antropozoógeno. La presencia de taxones de ribera (Alnus y Fraxinus) y las variaciones de Cyperaceae, como representante mayoritario de los taxones higro-hidrófilos, definen importantes fluctuaciones en la tasa de humedad. La información proporcionada por los valores del pH (5,4-6,2) y de la conductividad (10-160 μS/cm) del sedimento, constatan los cambios detectados en la vegetación y en los usos del suelo. [ABSTRACT] Here we present palynological analyses carried avow a peaty located near to Rascafría village (Lozoya valley river, Madrid). Vegetation evolution during Late Holocene (940±50 BP) is reconstructed. The results shows a landscape dominated by herbaceous taxa, constituted mainly Cichorioideae, Asteraceae, Chenopodiaceae, Poaceae and Plantago lanceolata. Shrubs such as Erica arborea, Rosaceae, Juniperus and Cistaceae have certain role in the vegetation. Woodlands with Pinus sylvestris, P. pinaster and Quercus, Corylus and Betula are also noticeable throushout the sequence. Non-pollen palynomorphs like Pseudoschizaea circula and Glomus are used to infer the importance of erosive processes in situ. This information shows an open mediterranean landscape, due mainly to human activities, and changes in peatbog trophic condition. Changes in values of Alnus, Fraxinus and Cyperaceae are used to detected humid changes in the area. The information provided by pH (5,4-6,2) and sediment conductivity (10-160 μS/cm) serves to assess vegetation and land uses changes

Reconstrucción paleoambiental y paleoclímática en el entorno del valle del Lozoya: valoración del impacto humano

Se presentan los datos palinológicos, procedentes de un testigo obtenido en el depósito higroturboso RAS, situado en el término municipal de Rascafría (Valle del Lozoya, Madrid), y cuya formación es posterior a los 2.455±35 BP (670-410 BC). Los resultados obtenidos se explican como consecuencia de la interacción del clima y del hombre en el área de estudio. Se trata de un paisaje vegetal abierto, dominado por herbáceas tipo Cichorioideae, Asteraceae, Chenopodiaceae, Poaceae y Plantago lanceolata, acompañado de un pobre cortejo arbustivo (Erica arborea, Rosaceae, Juniperus y Cistaceae) y arbóreo (Pinus sylvestris, en menor proporción P. pinaster y Quercus, y algunas presencias de Betula, y Corylus). De los microfósiles no polínicos destacan Pseudoschizaea circula y Glomus, relacionados con procesos erosivos in situ favorecidos por fenómenos de sobrepastoreo así como los que definen las condiciones tróficas de la turbera. Esta información pone de manifiesto la presencia de un paisaje de carácter mediterráneo, abierto y antropizado, dominado por zonas de pastizal dedicadas al ganado, según se deduce en el diagrama polínico a través de las proporciones de los componentes nitrófilos de carácter zoógeno y antropozoógeno. La presencia de taxones de ribera (Alnus y Fraxinus) y las variaciones de Cyperaceae, representante mayoritario de los taxones higro-hidrófilos, se infieren fluctuaciones en la tasa de humedad. La información proporcionada por los valores de MS (3-12), del pH (5,4-6,2) y de la conductividad (10-160 μS/cm) del sedimento, constatan los cambios detectados en la vegetación y en los usos del suelo

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium.

The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It derives from the proepicardium (PE), cell clusters that appear in the dorsal pericardium (DP) close to the atrioventricular canal and the venous pole of the heart, and are released into the pericardial cavity. PE cells are advected around the beating heart until they attach to the myocardium. Bmp and Notch signaling influence PE formation, but it is unclear how both signaling pathways interact during this process in the zebrafish. Here, we show that the developing PE is influenced by Notch signaling derived from the endothelium. Overexpression of the intracellular receptor of notch in the endothelium enhances bmp expression, increases the number of pSmad1/5 positive cells in the DP and PE, and enhances PE formation. On the contrary, pharmacological inhibition of Notch1 impairs PE formation. bmp2b overexpression can rescue loss of PE formation in the presence of a Notch1 inhibitor, but Notch gain-of-function could not recover PE formation in the absence of Bmp signaling. Endothelial Notch signaling activates bmp expression in the heart tube, which in turn induces PE cluster formation from the DP layer.Nadia Mercader was funded by the Spanish Ministry of Economy and Competitiveness through grant BFU2014-56970-P (Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016. Programa Estatal de I+D+i Orientada a los Retos de la Sociedad Retos Investigación: Proyectos I+D +i 2016, del Ministerio de Economía competitividad e Industria), and cofunding by Fondo Europeo de Desarrollo Regional (FEDER). Nadia Mercader is also supported by the European Industrial Doctorate Program EID 722427. Nadia Mercader and Julien Vermot are supported by the Swiss National Science Foundation grant ANR-SNF 310030L_182575. This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 708312 (MP) and from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme: GA Nº682938. Laura Andrés-Delgado was funded (2014-16) through the postdoctoral fellowship Ayudas Postdoctorales 2013. José Luis de la Pompa was supported by grants SAF2016-78370-R, CB16/11/00399 (CIBER CV) and RD16/0011/0021 (TERCEL) from the Spanish Ministry of Science and Innovation. The CNIC is supported by the Ministry of Science and Innovation and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S

Trends in socioeconomic inequalities in cancer mortality in Barcelona: 1992–2003

<p>Abstract</p> <p>Background</p> <p>The objective of this study was to assess trends in cancer mortality by educational level in Barcelona from 1992 to 2003.</p> <p>Methods</p> <p>The study population comprised Barcelona inhabitants aged 20 years or older. Data on cancer deaths were supplied by the system of information on mortality. Educational level was obtained from the municipal census. Age-standardized rates by educational level were calculated. We also fitted Poisson regression models to estimate the relative index of inequality (RII) and the Slope Index of Inequalities (SII). All were calculated for each sex and period (1992–1994, 1995–1997, 1998–2000, and 2001–2003).</p> <p>Results</p> <p>Cancer mortality was higher in men and women with lower educational level throughout the study period. Less-schooled men had higher mortality by stomach, mouth and pharynx, oesophagus, larynx and lung cancer. In women, there were educational inequalities for cervix uteri, liver and colon cancer. Inequalities of overall and specific types of cancer mortality remained stable in Barcelona; although a slight reduction was observed for some cancers.</p> <p>Conclusion</p> <p>This study has identified those cancer types presenting the greatest inequalities between men and women in recent years and shown that in Barcelona there is a stable trend in inequalities in the burden of cancer.</p

Age and date for early arrival of the Acheulian in Europe (Barranc de la Boella, la Canonja, Spain)

The first arrivals of hominin populations into Eurasia during the Early Pleistocene are currently considered to have occurred as short and poorly dated biological dispersions. Questions as to the tempo and mode of these early prehistoric settlements have given rise to debates concerning the taxonomic significance of the lithic assemblages, as trace fossils, and the geographical distribution of the technological traditions found in the Lower Palaeolithic record. Here, we report on the Barranc de la Boella site which has yielded a lithic assemblage dating to ,1 million years ago that includes large cutting tools (LCT). We argue that distinct technological traditions coexisted in the Iberian archaeological repertoires of the late Early Pleistocene age in a similar way to the earliest sub-Saharan African artefact assemblages. These differences between stone tool assemblages may be attributed to the different chronologies of hominin dispersal events. The archaeological record of Barranc de la Boella completes the geographical distribution of LCT assemblages across southern Eurasia during the EMPT (Early-Middle Pleistocene Transition, circa 942 to 641 kyr). Up to now, chronology of the earliest European LCT assemblages is based on the abundant Palaeolithic record found in terrace river sequences which have been dated to the end of the EMPT and later. However, the findings at Barranc de la Boella suggest that early LCT lithic assemblages appeared in the SW of Europe during earlier hominin dispersal episodes before the definitive colonization of temperate Eurasia took place.The research at Barranc de la Boella has been carried out with the financial support of the Spanish Ministerio de Economı´a y Competitividad (CGL2012- 36682; CGL2012-38358, CGL2012-38434-C03-03 and CGL2010-15326; MICINN project HAR2009-7223/HIST), Generalitat de Catalunya, AGAUR agence (projects 2014SGR-901; 2014SGR-899; 2009SGR-324, 2009PBR-0033 and 2009SGR-188) and Junta de Castilla y Leo´n BU1004A09. Financial support for Barranc de la Boella field work and archaeological excavations is provided by the Ajuntament de la Canonja and Departament de Cultura (Servei d’Arqueologia i Paleontologia) de la Generalitat de Catalunya. A. Carrancho’s research was funded by the International Excellence Programme, Reinforcement subprogramme of the Spanish Ministry of Education. I. Lozano-Ferna´ndez acknowledges the pre-doctoral grant from the Fundacio´n Atapuerca. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors

In order to identify genetic factors related to thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved in thyroid cell differentiation and proliferation, and in genes found to be differentially expressed in thyroid carcinoma. A total of 768 SNPs in 97 genes were genotyped in a Spanish series of 615 cases and 525 controls, the former comprising the largest collection of patients with this pathology from a single population studied to date. SNPs in an LD block spanning the entire FOXE1 gene showed the strongest evidence of association with papillary thyroid carcinoma susceptibility. This association was validated in a second stage of the study that included an independent Italian series of 482 patients and 532 controls. The strongest association results were observed for rs1867277 (OR[per-allele] = 1.49; 95%CI = 1.30–1.70; P = 5.9×10−9). Functional assays of rs1867277 (NM_004473.3:c.−283G>A) within the FOXE1 5′ UTR suggested that this variant affects FOXE1 transcription. DNA-binding assays demonstrated that, exclusively, the sequence containing the A allele recruited the USF1/USF2 transcription factors, while both alleles formed a complex in which DREAM/CREB/αCREM participated. Transfection studies showed an allele-dependent transcriptional regulation of FOXE1. We propose a FOXE1 regulation model dependent on the rs1867277 genotype, indicating that this SNP is a causal variant in thyroid cancer susceptibility. Our results constitute the first functional explanation for an association identified by a GWAS and thereby elucidate a mechanism of thyroid cancer susceptibility. They also attest to the efficacy of candidate gene approaches in the GWAS era

AGN STORM 2. I. First results: A Change in the Weather of Mrk 817

We present the first results from the ongoing, intensive, multiwavelength monitoring program of the luminous Seyfert 1 galaxy Mrk 817. While this active galactic nucleus was, in part, selected for its historically unobscured nature, we discovered that the X-ray spectrum is highly absorbed, and there are new blueshifted, broad, and narrow UV absorption lines, which suggest that a dust-free, ionized obscurer located at the inner broad-line region partially covers the central source. Despite the obscuration, we measure UV and optical continuum reverberation lags consistent with a centrally illuminated Shakura–Sunyaev thin accretion disk, and measure reverberation lags associated with the optical broad-line region, as expected. However, in the first 55 days of the campaign, when the obscuration was becoming most extreme, we observe a de-coupling of the UV continuum and the UV broad emission-line variability. The correlation recovered in the next 42 days of the campaign, as Mrk 817 entered a less obscured state. The short C IV and Lyα lags suggest that the accretion disk extends beyond the UV broad-line region. Unified