Regulatory dendritic cell treatment prevents the development of vasopressin-induced preeclampsia

The concept that persistent feto-placental intolerance is important in the pathogenesis of preeclampsia (PE) has been demonstrated by our lab and others. Arginine vasopressin (AVP) infusion during pregnancy induces cardiovascular, renal, and immune alterations in mice consistent with human PE. These findings identify AVP as a potential contributor to poor fetal tolerance and the development of PE. In addition to their conventional immuno-stimulatory role, dendritic cells (DCs) also play a vital role in immune tolerance. In contrast to conventional DCs, regulatory DCs (DCregs) express low levels of co-stimulatory markers, produce anti-inflammatory cytokines, induce T regulatory cells, and promote tolerance. In mice, DCregs are able to prevent pro-inflammatory responses and induce antigen-specific tolerance. Given these known functions of DCregs, we hypothesize that DCregs will prevent the development of AVP-induced PE

Betamethasone: a novel therapeutic intervention for preeclampsia

The early pathogenesis of preeclampsia (PE) involves a systemic inflammatory immune response. Recent data demonstrate that increased circulating arginine vasopressin (AVP) in humans is predictive of PE and that infusion of AVP in mouse dams phenocopies the pregnancy-specific cardiovascular and immune alterations observed in human PE. Specifically, AVP suppresses anti-inflammatory cytokines and cells. Betamethasone (BMTZ), commonly given to women at risk for preterm birth, is both an AVP and immune response modulator. We hypothesize that early treatment with BMTZ will prevent the development of AVP-induced PE

Static urine osmolality with elevated first trimester urine copeptin in human preeclampsia

We have previously shown that maternal plasma copeptin (CPP), as a marker of vasopressin, is highly predictive of preeclampsia (PE) in the first trimester and remains elevated throughout pregnancy. Furthermore, in maternal urine samples we demonstrated that CPP was also significantly elevated in the first trimester in women who later developed PE. Because a urine dipstick test could be easily used in the clinic, we sought to validate this finding in a new and expanded cohort of samples and to determine whether these changes persist throughout pregnancy. In addition, to begin to address the mechanism for this difference, we also assessed urine osmolality to further probe renal function

Recombinants between Deformed wing virus and Varroa destructor virus-1 may prevail in Varroa destructor-infested honeybee colonies

We have used high-throughput Illumina sequencing to identify novel recombinants between deformed wing virus (DWV) and Varroa destructor virus-1 (VDV-1), which accumulate to higher levels than DWV in both honeybees and Varroa destructor mites. The recombinants, VDV-1VVD and VDV-1DVD, exhibit crossovers between the 5’-untranslated region (5’-UTR), and/or the regions encoding the structural (capsid) and non-structural viral proteins. This implies the genomes are modular and that each region may evolve independently, as demonstrated in human enteroviruses. Individual honeybee pupae were infected with a mixture of observed recombinants and DWV. The strong correlation between VDV-1DVD levels in honeybee pupae and the associated mites was observed, suggesting that this recombinant, with a DWV-derived 5’-UTR and non-structural protein region flanking VDV- 1-derived capsid encoding region, is better adapted to transmission between V. destructor and honeybees than the parental DWV or a recombinant bearing the VDV-1-derived 5’-UTR (VDV-1VVD)

Diseño de pavimento con adoquines permeables en calles de baja transitabilidad vehicular de la Urbanización San Carlos–José Leonardo Ortiz

La presente investigación se basa en la creación de pavimentos con adoquines drenantes, para vías de bajo tránsito vehicular en la Urb. San Carlos debido a la crecida de precipitaciones por fenómenos del niño; estos a su vez, serán trabajados con 2 diseños de mezclas: 10% y 15% de agregado fino, en el concreto permeable empleado para obtener una resistencia mínima de 330 kg/cm2 y un coeficiente de permeabilidad mínimo de 0.14 cm/s, cumpliendo con la ACI-522R. Tras los estudios realizados, se brindan los siguientes resultados: se demostró que la vía es de bajo tránsito o ligero, debido a que tienen un EALs vehicular de 0.80 x 10^5; tiene un intensidad máxima de 22.258mm/s; la pendiente va de la calle Av. Augusto B. Leguía a la Av. Dorado; para el diseño más óptimo, arrojó un f’c a los 28 días fueron de 385.13 kg/cm2, respectivamente y una permeabilidad a los 14 días de un máximo de 0.13999 cm/s, cumpliendo con la ACI 522-R. Asimismo, se diseñó un pavimento adoquinado con un adoquín de espesor de 80mm, una cama granular de 50mm, una base granular de 100mm, una subbase granular de 100mm, una tubería de 6”y una geomembrana de 0.50mm. Además, se analizó la rentabilidad de este pavimento a un precio de s/.3,052,290.65.The present investigation is based on the creation of pavements with draining pavers, for roads with low vehicular traffic in Urb. San Carlos due to the increase of precipitations caused by the phenomena of El Niño; these in turn, will be worked with 2 mix designs: 10% and 15% of fine aggregate, in the permeable concrete used to obtain a minimum resistance of 330 kg/cm2 and a minimum permeability coefficient of 0.14 cm/s, complying with the ACI-522R. After the studies carried out, the following results were obtained: it was demonstrated that the roadway is low or light traffic, since it has a vehicular EALs of 0.80 x 10^5; it has a maximum intensity of 22.258mm/s; the slope goes from Av. Augusto B. Leguía to Av. Leguía to Av. Dorado; for the most optimal design, the f'c at 28 days was 385.13 kg/cm2, respectively, and the permeability at 14 days was a maximum of 0.13999 cm/s, complying with ACI 522-R. Likewise, a cobblestone pavement was designed with an 80 mm thick paver, a 50 mm granular bed, a 100 mm granular base, a 100 mm granular subbase, a 6" pipe and a 0.50 mm geomembrane. In addition, the cost-effectiveness of this pavement was analyzed at a price of s/.3,052,290.65

Toric G_2 and Spin(7) holonomy spaces from gravitational instantons and other examples

Non-compact G_2 holonomy metrics that arise from a T^2 bundle over a hyper-Kahler space are discussed. These are one parameter deformations of the metrics studied by Gibbons, Lu, Pope and Stelle in hep-th/0108191. Seven-dimensional spaces with G_2 holonomy fibered over the Taub-Nut and the Eguchi-Hanson gravitational instantons are found, together with other examples. By considering the Apostolov-Salamon theorem math.DG/0303197, we construct a new example that, still being a T^2 bundle over hyper-Kahler, represents a non trivial two parameter deformation of the metrics studied in hep-th/0108191. We then review the Spin(7) metrics arising from a T^3 bundle over a hyper-Kahler and we find two parameter deformation of such spaces as well. We show that if the hyper-Kahler base satisfies certain properties, a non trivial three parameter deformations is also possible. The relation between these spaces with the half-flat structures and almost G_2 holonomy spaces is briefly discussed.Comment: 27 pages. Typos corrected. Accepted for publication in Commun.Math.Phy

Factores que aumentan el uso de canales electrónicos en los clientes de banca mayorista de Scotiabank de la agencia Trujillo, 2017

RESUMEN El presente trabajo de investigación se basa en el estudio de los clientes de la banca mayorista para determinar qué factores los conducen a concretar sus operaciones bancarias por los canales electrónicos. Para lo cual nuestro objetivo principal es identificar los factores que aumentan el uso de canales electrónicos en los clientes de banca mayorista de Scotiabank de la Agencia Trujillo. Este estudio es de tipo no experimental, transversal y descriptivo, en el cual para obtener los resultados de nuestro objetivo hemos aplicado como herramienta una encuesta de preguntas cerradas a nuestra muestra de 60 empresas de la banca mayorista de Scotiabank. Asimismo las autoras de esta tesis hemos realizado observación directa de las plataformas que brinda Scotiabank a sus clientes. Con la información recogida a través de estas herramientas, hemos estructurado un marco conceptual desde las definiciones básicas y los modelos teóricos de adopción de tecnología, explicando y comparando los modelos con las dimensiones de nuestra variable. Las principales respuestas de la encuesta realizada a las empresas de banca mayorista hemos logrado obtener la información para nuestro objetivo tanto general como específicos, donde hemos levantado información para medir niveles de confianza, facilidad de uso, utilidad percibida y hasta la influencia social que determinan el uso de los canales electrónicos. Esta información es sumamente importante no solo para los funcionarios de Scotiabank para que concreten operaciones con los clientes, sino para escuchar sus necesidades y que es lo que requieren para concretar sus operaciones de manera digital, sin la necesidad de acercarse físicamente a una agencia bancaria. Con lo indicado anteriormente, esta tesis puede ser utilizada para armar estrategias y revolucionar los canales electrónicos en base a los factores que muestran en las encuestas. Finalmente, en la presente tesis brindamos nuestras recomendaciones para mejorar las plataformas de canales electrónicos de Scotiabank, buscando la satisfacción del cliente según sus necesidades identificadas.ABSTRACT This research is based on the study of wholesale banking clients to determine what factors lead them to make their banking operations through electronic channels. For this purpose our main objective is to identify the factors that increase the use of electronic channels in Scotiabank's wholesale banking customers of Agencia Trujillo. This study is non-experimental, cross-sectional and descriptive, in which to obtain the results of our objective we have applied as a tool a survey of closed questions to our sample of 60 companies of wholesale banking of Scotiabank. Also the authors of this thesis have made direct observation of the platforms offered by Scotiabank to its customers. With the information gathered through these tools, we have structured a conceptual framework from the basic definitions and theoretical models of technology adoption, explaining and comparing the models with the dimensions of our variable. The main responses of the survey to the wholesale banking companies have been able to obtain the information for our general and specific objective, where we have collected information to measure levels of confidence, ease of use, perceived utility and even social influence that determine the Use of electronic channels. This information is extremely important not only for Scotiabank employees to perform operations with customers, but to listen to their needs and what is required to realize their operations in a digital way, without the need to physically approach a banking agency. As indicated above, this thesis can be used to build strategies and revolutionize electronic channels based on the factors they show in the surveys. Finally, in this thesis we offer our recommendations to improve the platforms of electronic channels of Scotiabank, seeking the satisfaction of the customer according to their identified needs

New non compact Calabi-Yau metrics in D=6

A method for constructing explicit Calabi-Yau metrics in six dimensions in terms of an initial hyperkahler structure is presented. The equations to solve are non linear in general, but become linear when the objects describing the metric depend on only one complex coordinate of the hyperkahler 4-dimensional space and its complex conjugated. This situation in particular gives a dual description of D6-branes wrapping a complex 1-cycle inside the hyperkahler space, which was studied by Fayyazuddin. The present work generalize the construction given by him. But the explicit solutions we present correspond to the non linear problem. This is a non linear equation with respect to two variables which, with the help of some specific anzatz, is reduced to a non linear equation with a single variable solvable in terms of elliptic functions. In these terms we construct an infinite family of non compact Calabi-Yau metrics.Comment: A numerical error has been corrected together with the corresponding analysis of the metri

Desarrollo de una bebida refrescante con Medusomyces Gisevi y su aceptación en el mercado local - 2020

El presente trabajo de investigación tuvo como objetivo desarrollar una bebida refrescante con Medusomyces Gisevi para determinar su aceptación en el mercado local – 2020, donde la metodología empleada fue de tipo aplicada con un diseño pre-experimental; donde para su desarrollo se elaboró un diagrama de análisis de operaciones, un diagrama de bloques y un balance de materia, además de la evaluación organolépticas y fisicoquímicas para cada presentación, así mismo se investigó los beneficios generales de cada bebida, y se obtuvo una demanda de 673 tn/año, aplicando un focus group a 20 participantes donde la preferencia fue del 70% para el cedrón, 25% para toronjil y el 5% para jamaica, así mismo se evaluó un proyecto industrial con un VAN de S/.3.066.644,04 y un TIR de 192%. Es así que se concluyó que se necesitan 45 procesos unitarios, 26 bloques, así mismo se obtuvo unas características organolépticas aceptables y º brix de 9.8, 7 y 9, pH de 3.30, 2.70 y 3.51 y una densidad de 1, para las presentación respectivamente mencionada, así también la bebidas fueron aceptadas por el mercado y para un proyecto industrial la evaluación es viable bajo las condiciones establecidas