Preeclampsia and MicroRNAs

Preeclampsia is a critical gestational condition that threatens the life of both mother and child. One of the most serious aspects of preeclampsia hampering both clinical management and scientific understanding is that there are, as yet, no early warning signs or risk markers. The discovery of microRNAs (miRNAs), tiny post-transcriptional regulators of gene expression, offers potentially fertile ground for developing such markers. The current state of knowledge about miRNAs in preeclampsia is presented along with information regarding miRNA detection in peripheral fluids that could lead to minimally invasive risk assessment

Anti-Müllerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy

Follicle-Stimulating Hormone (FSH) drops rapidly in pregnancy but Anti-Mullerian Hormone (AMH) has not been shown to drop until about 12 weeks. Since the follicles that secrete AMH are thought to be FSH independent, AMH levels should slowly decline in the absence of FSH because when the follicles reach FSH dependence, they would die off. A study has presented data that suggests a decline in AMH levels suddenly starts at 12 weeks gestation. The present study agrees with a decline in AMH after the first trimester. There is a sharp decline in AMH at 12-16 weeks gestation indicating that the follicular development is actively suppressed, not passively lost because of a drop in FSH. It appears that pregnancy may be a unique situation in regards to AMH

Anti-Müllerian Hormone concentration levels in maternal plasma during the first, second and third trimester of pregnancy

Follicle-Stimulating Hormone (FSH) drops rapidly in pregnancy but Anti-Mullerian Hormone (AMH) has not been shown to drop until about 12 weeks. Since the follicles that secrete AMH are thought to be FSH independent, AMH levels should slowly decline in the absence of FSH because when the follicles reach FSH dependence, they would die off. A study has presented data that suggests a decline in AMH levels suddenly starts at 12 weeks gestation. The present study agrees with a decline in AMH after the first trimester. There is a sharp decline in AMH at 12-16 weeks gestation indicating that the follicular development is actively suppressed, not passively lost because of a drop in FSH. It appears that pregnancy may be a unique situation in regards to AMH

Evaluation of the VNTR region in the IDO promoter in women with preeclampsia

Indoleamine 2,3 – dioxygenase (IDO) is an enzyme that aids in immunosuppression and tolerance. Previous studies have shown decreased IDO activity in pregnancies affected by preeclampsia, but the mechanism for this altered activity is unknown. Our study was designed to analyze the promoter region of IDO in preeclamptic and control women and identify the frequency of a VNTR genotype that has been shown to be significantly correlated with tryptophan levels in women; a surrogate marker for IDO activity

Division of Reproductive Science Research

The Division of Reproductive Science Research at the University of Iowa has a long tradition and was formally organized in 2009. Since then, the division has enjoyed extensive growth and development in many areas of reproductive research. Sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the NIH Office of Research on Women’s Health, a Women’s Reproductive Health Research Career Development Center, was established to train future physician-scientists. Further, to enhance our capability to perform translational research, the Women’s Health Tissue Repository was established. This robust bio-repository includes the Maternal Fetal Tissue Bank, the Paternal Contributions to Children’s Health Biobank, the Well Woman Bank, the Reproductive Endocrinology and Infertility Biobank, and the Gynecologic Malignancies Biobank. Together, these biobanks collect samples from all stages of women’s lives and have deep clinical annotations

Global fetal DNA methylation and birth outcomes in obese women

Pregnant women who are obese are more likely to have gestational diabetes, gestational hypertension, pre-eclampsia, macrosomia, operative vaginal delivery, and cesarean delivery. Obesity also has adverse implications for the neonate. Congenital anomalies are more common in children born to obese women. These include neural tube defects, gastroschisis, cardiovascular anomalies, and others. Although the connection between maternal obesity and chronic health conditions has been described, the mechanism by which this occurs is less well understood. Changes to the epigenetic structure of offspring DNA have been proposed as one such mechanism

USING GHSL TO ANALYZE URBANIZATION AND LAND-USE EFFICIENCY IN THE PHILIPPINES FROM 1975–2020: TRENDS AND IMPLICATIONS FOR SUSTAINABLE DEVELOPMENT

This study analyzed the trends and patterns of urbanization and changes in land-use efficiency in the Philippines from 1975–2020 using the Global Human Settlement Layers (GHSL). Utilizing the GHS-BUILT-S, GHS POP, and GHS-SMOD raster datasets from the GHSL Data Package 2023, we examined the spatiotemporal expansion of built-up areas and the growth of population in urban and rural regions of the country. Using the same datasets, we also measured the country's achievement of Sustainable Development Goal (SDG)11.3, particularly on inclusive and sustainable urbanization through efficient land utilization, by computing the ratio of land consumption rate (LCR) to the population growth rate (PGR), also known as LCRPGR. The results of our analysis revealed an increasing trend in the overall built-up area and population of the Philippines within the examined period. Built-up areas and population in urban regions more than tripled in size from 1975 to 2020, demonstrating a notable shift towards more urbanized regions over time. In addition to presenting evidence of the Philippines' developmental progress and urbanization, our analysis of GHSL data shows a decline in land consumption, a deceleration in population growth, and an overall enhancement in land-use efficiency within the country. These findings suggest a shift towards more controlled and sustainable land development practices, supporting the country's goal of sustainable urbanization and land management. The implications of these findings are crucial for policymakers and urban planners in the Philippines, offering valuable insights to guide the formulation of effective and comprehensive land management strategies. Further work includes conducting localized analyses at the city or municipality level to provide valuable insights into the unique urbanization patterns and land-use dynamics across different islands and regions, enabling tailored policy interventions and spatial planning strategies to promote sustainable development

ANALYZING THE IMPACTS OF LAND COVER CHANGE TO THE HYDROLOGIC AND HYDRAULIC BEHAVIOURS OF THE PHILIPPINES' THIRD LARGEST RIVER BASIN

Changes in land cover can have negative impacts on the hydrological and hydraulic processes in river basins and watersheds such as increase in surface runoff and peak flows, and greater incidence, risk and vulnerability of flooding. In this study, the impacts of land-cover changes to the hydrologic and hydraulic behaviours of the Agusan River Basin (ARB), the third largest river basin in the Philippines, was analysed using an integrated approach involving Remote Sensing (RS), Geographic Information System (GIS), and hydrologic and hydraulic models. Different land-cover classes in the ARB for the years 1995 and 2017 were mapped using Landsat 5 TM and Landsat 8 OLI images. Using a post-classification change detection approach, changes in land-cover were then determined. The impacts of these changes in land-cover to the to the basin discharge were then estimated using a calibrated hydrologic model based on the Hydrologic Engineering Center - Hydrologic Modeling System (HEC-HMS) under different extreme rainfall conditions. The impact of the changes in land-cover to flood depth and extent was also determined using a hydraulic model based on the HEC-RAS (River Analysis System). Land cover classification results revealed that the ARB is 67.7% forest in 1995 but have decreased to 62.8% in 2017. Agricultural areas in the basin were also found to have increased from 12.2% to 15.5% in the same period. Other notable land cover changes detected include the increase in built-up lands and range lands, and decrease in barren lands. HEC HMS and HEC RAS model simulation results showed that there was an increase in discharge, flood depth, and flood extents between 1995 and 2017, implying that that the detected changes in land cover have negative impacts to hydrologic and hydraulic behaviours of the ARB