Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health

Daily interactions between the hypothalamic circadian clock at the suprachiasmatic nucleus (SCN) and peripheral circadian oscillators regulate physiology and metabolism to set temporal variations in homeostatic regulation. Phase coherence of these circadian oscillators is achieved by the entrainment of the SCN to the environmental 24-h light:dark (LD) cycle, coupled through downstream neural, neuroendocrine, and autonomic outputs. The SCN coordinate activity and feeding rhythms, thus setting the timing of food intake, energy expenditure, thermogenesis, and active and basal metabolism. In this work, we will discuss evidences exploring the impact of different photic entrainment conditions on energy metabolism. The steady-state interaction between the LD cycle and the SCN is essential for health and wellbeing, as its chronic misalignment disrupts the circadian organization at different levels. For instance, in nocturnal rodents, non-24 h protocols (i.e., LD cycles of different durations, or chronic jet-lag simulations) might generate forced desynchronization of oscillators from the behavioral to the metabolic level. Even seemingly subtle photic manipulations, as the exposure to a "dim light" scotophase, might lead to similar alterations. The daily amount of light integrated by the clock (i.e., the photophase duration) strongly regulates energy metabolism in photoperiodic species. Removing LD cycles under either constant light or darkness, which are routine protocols in chronobiology, can also affect metabolism, and the same happens with disrupted LD cycles (like shiftwork of jetlag) and artificial light at night in humans. A profound knowledge of the photic and metabolic inputs to the clock, as well as its endocrine and autonomic outputs to peripheral oscillators driving energy metabolism, will help us to understand and alleviate circadian health alterations including cardiometabolic diseases, diabetes, and obesity.Fil: Plano, Santiago Andrés. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Casiraghi, Leandro Pablo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Moro, Paula. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paladino, Natalia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Golombek, Diego Andrés. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chiesa, Juan José. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Design of resistive-input class E resonant rectifiers for variable-power operation

Resonant rectifiers have important application in very-high-frequency power conversion systems, including dc-dc converters, wireless power transfer systems, and energy recovery circuits for radio-frequency systems. In many of these applications, it is desirable for the rectifier to appear as a resistor at its ac input port. However, for a given dc output voltage, the input impedance of a resonant rectifier varies in magnitude and phase as output power changes. A design method is introduced for realizing single-diode “shunt-loaded” resonant rectifiers, or class E rectifiers, that provide near-resistive input impedance over a wide range of output power levels. The proposed methodology is demonstrated in simulation for a 10:1 power range.MIT Skoltech InitiativeMassachusetts Institute of Technology. Center for Integrated Circuits and SystemsMassachusetts Institute of Technology. Microsystems Technology Laboratorie

Noncommutative spaces, the quantum of time and the Lorentz symmetry

We introduce three space-times that are discrete in time and compatible with the Lorentz symmetry. We show that these spaces are no commutative, with commutation relations similar to the relations of the Snyder and Yang spaces. Furthermore, using a reparametrized relativistic particle we obtain a realization of the Snyder type spaces and we construct an action for them.Comment: 8 pages, to appear in PR

A preliminary gadget model to assess the Spanish Red seabream fishery of the Strait of Gibraltar

This work shows the first implementation of gadget (an age-length based model) to the Spanish Red seabream fishery data from the Strait of Gibraltar: gadget is a toolbox developed to implement marine ecosystem models considering the fishing effect. Our goal is to launch a new approach for the Red seabream fishery assessment following Icelandic deepwater stocks example. Sooner or later, we would like to change the current category of this deep water fishery: from data poor to stocks with quantitative assessments. These trials should be attempted before planning a future Benchmark Grou

The curious case of PHL 293B: a long-lived transient in a metal-poor blue compact dwarf galaxy

Artículo escrito por un elevado número de autores, sólo se referencian el que aparece en primer lugar, los autores pertenecientes a la UAM y el nombre del grupo de colaboración, si lo hubiereWe report on small-amplitude optical variability and recent dissipation of the unusually persistent broad emission lines in the blue compact dwarf galaxy PHL 293B. The galaxy's unusual spectral features (P Cygni-like profiles with ∼800 km s-1 blueshifted absorption lines) have resulted in conflicting interpretations of the nature of this source in the literature. However, analysis of new Gemini spectroscopy reveals the broad emission has begun to fade after being persistent for over a decade prior. Precise difference imaging light curves constructed with the Sloan Digital Sky Survey and the Dark Energy Survey reveal small-amplitude optical variability of ∼0.1 mag in the g band offset by 100 21 pc from the brightest pixel of the host. The light curve is well-described by an active galactic nuclei (AGN)-like damped random walk process. However, we conclude that the origin of the optical variability and spectral features of PHL 293B is due to a long-lived stellar transient, likely a Type IIn supernova or nonterminal outburst, mimicking long-term AGN-like variability. This work highlights the challenges of discriminating between scenarios in such extreme environments, relevant to searches for AGNs in dwarf galaxies. This is the second long-lived transient discovered in a blue compact dwarf, after SDSS1133. Our result implies such long-lived stellar transients may be more common in metal-deficient galaxies. Systematic searches for low-level variability in dwarf galaxies will be possible with the upcoming Legacy Survey of Space and Time at the Vera C. Rubin ObservatoryThe DES data management system is supported by the National Science Foundation under grant Nos. AST-1138766 and AST-1536171. The DES participants from Spanish institutions are partially supported by MINECO under grants AYA2015-71825, ESP2015-66861, FPA2015-68048, SEV2016-0588, SEV-2016-0597, and MDM-2015-0509, some of which include ERDF funds from the European Union. IFAE is partially funded by the CERCA program of the Generalitat de Catalunya. Research leading to these results has received funding from the European Research Council under the European Union’s Seventh Framework Program (FP7/2007–2013) including ERC grant agreements 240672, 291329, and 30647

Aldol Reactions between L-Erythrulose Derivatives and Chiral α-Amino and α -Fluoro Aldehydes: Competition between Felkin–Anh and Cornforth Transition States

Both matched and mismatched diastereoselection have been observed in aldol reactions of a boron enolate of a protected l-erythrulose derivative with several chiral α-fluoro and α-Amino aldehydes. Strict adherence to the Felkin–Anh model for the respective transition structures does not account satisfactorily for all the observed results, as previously observed in the case of α-oxygenatedaldehydes. In some cases, only the Cornforth model provides a good explanation. The factors that influence this dichotomy are discussed and a general mechanistic model is proposed for aldol reactions with a-heteroatom-substituted aldehydes. Additional support for the model was obtained from density functional calculation

Evidencias del incremento en la movilidad de dunas costeras en el último medio siglo como respuesta a la intervención humana

Given the risk of two roads being buried by the sand of two highly mobile coastal dunes (Valdevaqueros and Bolonia, SW Spain), several measures have been taken over the last half century in order to stabilize them or at least slow their progress: installation of several rows of 1-m-high concrete structures, planting of species such as Pinus pinea, Retama monosperma and Ammophila arenaria, wicker and wooden fencing, and sand mining (only performed on the Valdevaqueros dunefield). The evolution of the two dunes was investigated through the interpretation of intensive topographical monitoring and aerial photography. Average migration rates of approximately 10 m yr–1 were detected and the burial of anthropic structures has eventually occurred. This process has caused a serious regional problem, making dune management of these areas a difficult challenge. The comparison of the evolution of these two dunes has been of great importance in assessing the effect of historical human intervention and has provided a new perspective for future dune management strategies. The results obtained show that management measures based on sand removal have been proven to be unsustainable. Moreover, the monitoring methodology presented herein has proven very useful in predicting dune advance rates. For instance, the Bolonia dune could reach the nearest road in approximately 12 years.Se han tomado diferentes medidas a lo largo del último medio siglo tratando de estabilizar o al menos ralentizar el progreso de dos dunas costeras de alta movilidad (Valdevaqueros y Bolonia, SW España) dado el riesgo de enterramiento de sendas carreteras: Entre las medidas tomadas cabe destacar la instalación de filas de estructuras de hormigón de 1 m de altura, la plantación de diferentes especies (como el Pinus pinea, la Retama monosperma o la Ammophila arenaria), vallas de madera y brezo, y la extracción de arena (sólo en la duna de Valdevaqueros). La evolución de ambas dunas se ha investigado a través de la comparación de levantamientos topográficos y fotografías aéreas. Se han detectado tasas medias de avance de aproximadamente 10 m/año hasta que, finalmente, se han enterrado estructuras antrópicas. Este proceso ha causado graves problemas convirtiendo en un difícil reto la gestión de dunas de estas áreas. La comparación de la evolución de estas dos dunas ha resultado de gran importancia a la hora de evaluar el efecto de la intervención humana, y ha proporcionado una nueva perspectiva para las futuras estrategias de gestión. Entre los resultados obtenidos, debería destacarse el que la gestión basada en la retirada de arena ha resultado insostenible. Además, la metodología de seguimiento aquí presentada ha probado ser de gran utilidad al predecir las tasas de avance de las dunas. Por ejemplo, la duna de Bolonia podría alcanzar la carretera próxima en unos 12 años