Koinonia

Leadership Spotlight FeaturesDeveloping Servant Leaders: The Tale of Two Questions, Kevin Johnson Life at the Cross Roads: Living out the Eternal in the Midst of the Temporal, Brent Ellis Leadership Process vs. Results (Regardless of Culture, Country or Gender), Rebecca Sok Leading During Times of Conflict: Lessons from the Early Church, Carl Ruby From Fiction to Fact, Benjamin Kulpa Thinking TheologicallyCharismatic Boy Meets Reformed Girl, Michael and Stephanie Santarosa Book ReviewsA Review of Integrity: The Courage to Face the Demands of Reality (by Henry Cloud), reviewed by Aaron Damiani Leadership Can Be Taught (by Sharon Daloz Parks), reviewed by Laura M. Rodeheaver FeaturesThe President\u27s Corner Editor\u27s Desk Regional Updateshttps://pillars.taylor.edu/acsd_koinonia/1011/thumbnail.jp

Koinonia

Spotlight FeaturesSovereign Stumbling: My Life Journey to Date, Larry Crabb Conversations About Racism, Jessie Brown Anxiety: A Growing Problem in College Students, Steven M. Conn Thinking TheologicallyTeaching the Truth, Michael and Stephanie Santarosa Book ReviewsKingdom Triangle: Recover the Christian Mind, Renovate the Soul, Restore the Spirit\u27s Power (by J.P. Moreland), reviewed by Steve Ivester The Soul of a Christian University: A Field Guide for Educators (edited by Stephen T. Beers), reviewed by Kyle Lantz The Outrageous Idea of Academic Faithfullness (by Donald Opitz and Derek Melleby), reviewed by Nathan Geer I Once Was Lost: What Postmodern Skeptics Taught Us About Their Path to Jesus (by Don Everts and Doug Schaupp), reviewed by Andrew D. Rowell FeaturesThe President\u27s Corner Editor\u27s Deskhttps://pillars.taylor.edu/acsd_koinonia/1012/thumbnail.jp

Koinonia

Spotlight FeaturesHas Facebook Jumped the Shark?, Rick Zomer The Good, the Bad, and the Ugly of Virtual Community, David Johnstone Screenagers: How Technology is Changing the Way we Interact with Students, Tim Elmore \u27In Loco Parentis\u27 Revisited, Gene C. Fant Jr. ACSD News: From Location to Interest: ACSD Considers Move from Regional to Collaboratives Model, Edee Schulze, Connie Sjoberg, Mike Broberg, David A. Kennedy, Nicole Hoefle Thinking TheologicallyKeeping Faith: Serving Students or the Kingdom, Michael and Stephanie Santarosa Book ReviewsEncouraging Authenticity and Spirituality in Higher Education, reviewed by Jason M. Morris My Freshman Year, Heidi Johnston FeaturesThe President\u27s Corner; Editor\u27s Deskhttps://pillars.taylor.edu/acsd_koinonia/1002/thumbnail.jp

Koinonia

Spotlight FeatureThinking Globally in a Local Context, Jolene Cassellius Family and Balance, Shannon Schans Cultivating Philanthropy in the Co-Curriculum: An Alternative to the Narcissism of the iGeneration, Brian Powell InterviewThe Ministry of Reconciliation: A Conversation with Brenda Salter McNeil, Glen Kinoshita Thinking TheologicallyThought About Thinking Lately? How About Thinking Christianly?, Michael Santarosa Book ReviewHush: Moving From Silence to Healing After Childhood Sexual Abuse, reviewed by Carol Harding I\u27m the Teacher, You\u27re the Student: A Semester in the University Classroom, reviewed by Ryan K. Giffin Reconciliation Blues: A Black Evangelical\u27s Inside View of White Christianity, reviewed by Jesse Brown FeaturesThe President\u27s Corner Editor\u27s Desk Regional Updateshttps://pillars.taylor.edu/acsd_koinonia/1080/thumbnail.jp

Novel Interactions between Actin and the Proteasome Revealed by Complex Haploinsufficiency

Saccharomyces cerevisiae has been a powerful model for uncovering the landscape of binary gene interactions through whole-genome screening. Complex heterozygous interactions are potentially important to human genetic disease as loss-of-function alleles are common in human genomes. We have been using complex haploinsufficiency (CHI) screening with the actin gene to identify genes related to actin function and as a model to determine the prevalence of CHI interactions in eukaryotic genomes. Previous CHI screening between actin and null alleles for non-essential genes uncovered ∼240 deleterious CHI interactions. In this report, we have extended CHI screening to null alleles for essential genes by mating a query strain to sporulations of heterozygous knock-out strains. Using an act1Δ query, knock-outs of 60 essential genes were found to be CHI with actin. Enriched in this collection were functional categories found in the previous screen against non-essential genes, including genes involved in cytoskeleton function and chaperone complexes that fold actin and tubulin. Novel to this screen was the identification of genes for components of the TFIID transcription complex and for the proteasome. We investigated a potential role for the proteasome in regulating the actin cytoskeleton and found that the proteasome physically associates with actin filaments in vitro and that some conditional mutations in proteasome genes have gross defects in actin organization. Whole-genome screening with actin as a query has confirmed that CHI interactions are important phenotypic drivers. Furthermore, CHI screening is another genetic tool to uncover novel functional connections. Here we report a previously unappreciated role for the proteasome in affecting actin organization and function

An exploration of moral potency among registrars and admission directors at U.S. colleges and universities

Many organizational leaders know the right course of action to take when facing moral dilemmas and yet fail to take the appropriate moral action. Moral potency, consisting of moral courage, moral efficacy, and moral ownership, is a new construct developed to help explain some of the motivational factors associated with organizational leaders who actually engage in morally commendable conduct. Given the prominence of lapses of ethical conduct among organizational leaders, there is growing interest in explaining the drivers of ethical actions in all industries including higher education. This research compared the relationship of moral potency among two groups of organizational leaders within higher education, registrars and admissions directors working at regionally accredited four-year colleges and universities in the United States, to see if significant differences existed that may help explain some of the positive and negative outcomes associated with the two professions. The hypotheses associated with this study were not supported because the data indicate that no significant difference exists among egistrars and admissions leaders related to the factors associated with moral potency. Both registrars and admissions directors possess relatively equally high levels of moral potency. However, a significant correlation was found for moral efficacy and size of institution suggesting that registrars and admissions directors working at larger institutions were more confident in their ability to address moral issues than those working at smaller institutions. Another positive correlation was found between moral courage and approximate number of years registrars and admissions directors served in in their respective positions providing evidenced that those holding their positions longer were more likely to persist in the pursuit of ethical behaviors despite hardships or negative pressures they may face

Pre- and intraoperative thoracic spine localization techniques: a systematic review

OBJECTIVE: In the era of modern medicine with an armamentarium full of state-of-the art technologies at our disposal, the incidence of wrong-level spinal surgery remains problematic. In particular, the thoracic spine presents a challenge for accurate localization due partly to body habitus, anatomical variations, and radiographic artifact from the ribs and scapula. The present review aims to assess and describe thoracic spine localization techniques. METHODS: The authors performed a literature search using the PubMed database from 1990 to 2020, compliant with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A total of 27 articles were included in this qualitative review. RESULTS: A number of pre- and intraoperative strategies have been devised and employed to facilitate correct-level localization. Some of the more well-described approaches include fiducial metallic markers (screw or gold), metallic coils, polymethylmethacrylate, methylene blue, marking wire, use of intraoperative neuronavigation, intraoperative localization techniques (including using a needle, temperature probe, fluoroscopy, MRI, and ultrasonography), and skin marking. CONCLUSIONS: While a number of techniques exist to accurately localize lesions in the thoracic spine, each has its advantages and disadvantages. Ultimately, the localization technique deployed by the spine surgeon will be patient-specific but often based on surgeon preference