13 research outputs found
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- DĂ©lphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco SaccĂ
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela CĂ©sar
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan HĂžjgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka ErÀlinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- MaurĂcio AndrĂ©Gheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- NatĂĄlia Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- PatrĂcia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- TomĂĄs Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- AndrĂ© Gheller Friedrich MaurĂcio
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Augusto da Silva Luiz
- Augusto Suriane Fialho TomĂĄs
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- CĂ©sar Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Ebru Bekircan-Kurt Can
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- ErÀlinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes PatrĂcia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria Cristina
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard Jr James
- Huynh Kristin
- HĂžjgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H
- Jara Jordan
- Javier Rodriguez de Rivera Francisco
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Barbora Kurkova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-Hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu DĂ©lphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
- Previous
- Previous
- Previous
- Pulley Michael
- Puorro Giorgia
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- SaccĂ Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sub-Investigators
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- T So Yuen
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tinerney Scott
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- Van Daele Sien
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoon Koh Da
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia gravis: A subgroup analysis of the REGAIN open-label extension study
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzales
- Alex Fondaw
- Ali Malekniazi
- Allessandro Filla
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral Andrade
- Ana Lazaro
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Andoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hondt
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Barohn
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Boscoe
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Burns
- Burns
- Buzzard
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chafic Karam
- Chafic Karam
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Conti-Fine
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Dai Matsuse
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Donna Carnes
- Doreen Ho
- DĂ©lphine Mahieu
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emiko Tsuda
- Engel-Nitz
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fanny OâBrien
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco SaccĂ
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fumie Meguro
- Gabor Lovas
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Giannis Sokratous
- Gil Wolfe
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H. James Jones
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Hidekazu Suzuki
- Hillmen
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Howard
- Howard
- Hui Gong
- Huned Patwa
- Husnu Efendi
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- James Howard Jr
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jaretzki
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelback
- Jeri Sieren
- Jerry Locheke
- Jing-Jing Wang
- Jiri Pitha
- Joan HĂžjgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josep Gamez
- Joseph Chad Hoyle
- Judit Matolcsi
- Juha-Pekka Eralinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kawaguchi
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kenichi Tsukita
- Kenji P. Fujita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kida
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Pokala
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Laurie Gutmann
- Legendre
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Licht
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutierrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Pasanisi
- Maria Salvado
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Makamori
- Matsuki
- Matteo Garibaldi
- Maureen Walsh
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Miriam Freimer
- Misa Shimpo
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammad Sanjak
- Mohammed Salajegheh
- Mona Elsayed
- Muppidi
- Muppidi
- Murai
- Murai
- Murai
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- NatĂĄlia Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Pamela CĂ©sar
- Paolo Emilio Alboini
- Patricia Fernandes
- Patricia Padilla
- Pedro Lopez Ruiz
- Petra Tilkin
- Pharmaceuticals and Medical Devices Agency Japan
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Renata Martins Ribeiro
- Renato Mantegazza
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rother
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sanders
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- Santos
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Scott Tierney
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- Soichiro Funaka
- Sonia Garcia
- Srikanth Muppidi
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Suh
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Mitazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Cochrane
- Thomas Harbo
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- TomĂĄs Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tuula Harrison
- Tuzun
- Utsugisawa
- Utsugisawa
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Waqar Waheed
- Wladimir Pinto
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasuko Maeda
- Yasushi Suzuki
- Yoko Ishiyama
- Yoko Kaneko
- Yoshiko Sano
- Yuen T. So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during REGAIN, treatment with open-label eculizumab resulted in generally similar outcomes in the Japanese and Caucasian populations. Rapid improvements were maintained for 52 weeks, assessed by change in score from open-label extension baseline to week 52 (mean [standard error]) using the following scales (in Japanese and Caucasian patients, respectively): Myasthenia Gravis Activities of Daily Living (â2.4 [1.34] and â 3.3 [0.65]); Quantitative Myasthenia Gravis (â2.9 [1.98] and â 4.3 [0.79]); Myasthenia Gravis Composite (â4.5 [2.63] and â 4.9 [1.19]); and Myasthenia Gravis Quality of Life 15-item questionnaire (â8.6 [5.68] and â 6.5 [1.93]). Overall, the safety of eculizumab was consistent with its known safety profile. In this interim sub-analysis, the efficacy and safety of eculizumab in Japanese and Caucasian patients were generally similar, and consistent with the overall REGAIN population
Consistent improvement with eculizumab across muscle groups in myasthenia gravis
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral de Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Ardoin Angela
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Augusto da Silva Luiz
- Augusto Suriane Fialho TomĂĄs
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- CĂ©sar Pamela
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- de Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- DâAmato Valentina
- DâHont Ann
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- ErÀlinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes PatrĂcia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Friedrich MaurĂcio AndrĂ© Gheller
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gonçalves Luiz Otavio Maia
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Huynh Kristin
- HĂžjgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H.
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
- Maier Gal
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Miyawaki Eriko
- Miyazaki Teiichiro
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamori Masayuki
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- O'Brien Fanny L.
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Pasquale Antonella
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- SaccĂ Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Scott Tierney
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Torres Debora Dada Martineli
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van Daele Sien
- van Damme Philip
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Yountz Marcus
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Wiley'
- Publication date
- 01/08/2020
- Field of study
Objective: To assess whether eculizumab, a terminal complement inhibitor, improves patient- and physician-reported outcomes (evaluated using the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale, respectively) in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis across four domains, representing ocular, bulbar, respiratory, and limb/gross motor muscle groups. Methods: Patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis were randomized 1:1 to receive either placebo or eculizumab during the REGAIN study (NCT01997229). Patients who completed REGAIN were eligible to continue into the open-label extension trial (NCT02301624) for up to 4Â years. The four domain scores of each of the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale recorded throughout REGAIN and through 130Â weeks of the open-label extension were analyzed. Results: Of the 125 patients who participated in REGAIN, 117 enrolled in the open-label extension; 61 had received placebo and 56 had received eculizumab during REGAIN. Patients experienced rapid improvements in total scores and all four domain scores of both the myasthenia gravis activities of daily living profile and the quantitative myasthenia gravis scale with eculizumab treatment. These improvements were sustained through 130Â weeks of the open-label extension. Interpretation: Eculizumab treatment elicits rapid and sustained improvements in muscle strength across ocular, bulbar, respiratory, and limb/gross motor muscle groups and in associated daily activities in patients with refractory anti-acetylcholine receptor antibody-positive generalized myasthenia gravis
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Ananias Morita Maria da Penha
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard J.
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Burns Ted M.
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Hwa
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- CĂ©sar Pamela
- D'Amato Valentina
- D'Hondt Ann
- da Cruz Pacheco Daiane
- da Silva Luiz Augusto
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- de Bleecker Jan L.
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Echevarria Laura
- Efendi Husnu
- Elsayed Mona
- Emmons Kelley
- Engel Marguerite
- Eralinna Juha-Pekka
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernandes Patricia
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Fialho TomĂĄs Augusto Suriane
- Filla Allessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fujita Kenji P.
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriele Maria
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gheller Friedrich MaurĂcio AndrĂ©
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Hendersen Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Hoyle Joseph Chad
- Huynh Kristin
- Hwang Eun Bi
- Hwang Ji Ye
- HĂžjgaard Joan
- Illa Isabel
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Jones H. James
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byoung Joon
- Kim Byung-Jo
- Kim Miri
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John T.
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Koo Dae Lim
- Koo Yong Seo
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee Chang Nyoung
- Lee HyeLim
- Lee Hyung Seok
- Lee JiEun
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Macagnan Ana Paula
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martineli Torres Debora Dada
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazia Claudio Gabriel
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Melo Ana Paula
- Mercelis Rudy
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard J.
- Nozaki Kenkichi
- Nye Joan
- O'Brien Fanny L.
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onar Musa Kazim
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ostergaard Autzen Anne
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paulose Shirley
- Pazetto Lucas Eduardo
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pokala Krishna
- Pol Sabrina
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Querol Gutierrez Luis Antonio
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- SaccĂ Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelback Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimpo Misa
- Shin Chae Won
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tierney Scott
- Tilkin Petra
- Tobon Gonzales Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van Daele Sien
- van Damme Philip
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan H.
- Vynckier Jan
- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Jing Jing
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Wiley'
- Publication date
- 01/07/2019
- Field of study
Introduction: Eculizumab is effective and well tolerated in patients with antiacetylcholine receptor antibody-positive refractory generalized myasthenia gravis (gMG; REGAIN; NCT01997229). We report an interim analysis of an open-label extension of REGAIN, evaluating eculizumab's long-term safety and efficacy. Methods: Eculizumab (1,200 mg every 2 weeks for 22.7 months [median]) was administered to 117 patients. Results: The safety profile of eculizumab was consistent with REGAIN; no cases of meningococcal infection were reported during the interim analysis period. Myasthenia gravis exacerbation rate was reduced by 75% from the year before REGAIN (P < 0.0001). Improvements with eculizumab in activities of daily living, muscle strength, functional ability, and quality of life in REGAIN were maintained through 3 years; 56% of patients achieved minimal manifestations or pharmacological remission. Patients who had received placebo during REGAIN experienced rapid and sustained improvements during open-label eculizumab (P < 0.0001). Discussion: These findings provide evidence for the long-term safety and sustained efficacy of eculizumab for refractory gMG. Muscle Nerve 2019
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Eculizumab in refractory generalized myasthenia gravis previously treated with rituximab: subgroup analysis of REGAIN and its extension study
- Author
- Acar  Nazire Pinar
- Agrawal  Brajesh
- Agriesti  Julie
- Aguilo  Maria Antonia Alberti
- Ahn  SoâHyun
- Akhter  Salma
- Akiyama  Tetsuya
- Alam  Sharmeen
- Alboini  Paolo Emilio
- Alcon  Karan
- Alsharabati  Mohammad
- Amamoto  Shoko
- Amato  Anthony
- Amato  Katherine
- Ambrosio  Daniel
- Andersen  Henning
- Anderson  Amanda
- Andrade  Ana Carolina Amaral
- Annes  Marcelo
- Antonini  Giovanni
- Antozzi  Carlo
- Aranke  Shachie
- Ardoin  Angela
- Arndt  Heike
- Arnold  Thomas
- ArribasâIbar  Elisabet
- Asada  Shizuka
- Assis  Natålia
- Autzen  Anne Mette Ostergaard
- Aydinlik  Seda
- Balkan  Bengu
- Barohn  Richard
- Barroso  Fabio
- Becerikli  Gulsah
- Beck  Kate
- Bednarik  Josef
- BekircanâKurt  Canâ Ebru
- Benatar  Michael
- Berger  Alan Ross
- Bertorini  Tulio
- Bettini  Mariela
- Beydoun  Said
- BhavarajuâSanka  Ratna
- Bilsker  Martin
- Bjarbo  Lena
- Blackmore  Derrick
- Bodkin  Cynthia
- Bonanno  Silvia
- Bravver  Elena
- Brockhausen  Igor Dias
- Brooks  Benjamin
- Brown  Claire
- Burdette  Maryanne
- Butinhao  Cristiani Fernanda
- Caliskan  Yagmur
- Callison  Karen
- Camera  Giorgia
- Campanella  Angela
- Carbonell  Josep Gamez
- Carnes  Donna
- Carrara  Fernanda
- Carter  Cynthia
- Casasnovas  Carlos
- Cash  Tiyonnoh
- Cassia Santos  Aline
- Cavdar  Tugce Kirbas
- Cavus  Hakan
- Chaudhry  Vinay
- Chaves  Marcelo
- Chelnick  Sharon
- Chilingaryan  Amaiak
- Chmelikova  Magda
- Cho  Eun Bin
- Choi  Eun Haw
- Choi  Mi Song
- Chopra  Manisha
- Cierny  Marek
- Cochrane  Thomas
- Coelho  Erica Nogueira
- Cooley  Anne
- Corse  Andrea
- Costabile  Teresa
- Cruz Pacheco  Daiane
- Cunningham  Scott
- César  Pamela
- D'Amato  Valentina
- D'Hont  Ann
- Daniels  Kevin
- Darnell  Taylor
- Davies  Debbie
- De Bleecker  Jan
- De Mey  Katrien
- Depreitere  Annelies
- Dezsi  Livia
- Di Pasquale  Antonella
- Di Pasquale  Antonella
- DiazâManera  Jordi
- Dicapua  Daniel
- Dimachkie  Mazen
- Dimitriou  Aikaterini
- Dimitrova  Diana
- DiSanzo  Beth
- Dishman  Lorraine
- Distad  Jane
- Doan  Victor
- Dogan  Baki
- Donahue  Craig
- Downing  Sharon
- Droker  Brian
- Duca  Luciana Souza
- Duran  Gustavo
- Echevarria  Laura
- Efendi  Husnu
- Elsayed  Mona
- Emmons  Kelley
- Engel  Marguerite
- Engel  Murilo Santos
- ErdemâOzdamar  Sevim
- Eriksson  Jaana
- ErĂ€linna  JuhaâPekka
- Evoli  Amelia
- Fasanaro  Angiola
- Feder  David
- Fernandes  PatrĂcia
- FernandezâFournier  Mireya
- FernandezâFournier  Mireya
- Ferreira  Luciana
- Fialho  Tomås Augusto Suriane
- Figueras  Maria Salvado
- Filla  Alessandro
- Fionda  Laura
- Fionda  Laura
- Fondaw  Alex
- Forshew  Dallas
- Frasca  Vittorio
- Frasca  Vittorio
- Freimer  Miriam
- Friedrich  MaurĂcio AndrĂ© Gheller
- Fujii  Yuko
- Fukuda  Yusuke
- Funaka  Soichiro
- Futono  Kazumi
- Gabriele  Maria
- Garcia  Alejandra Dalila
- Garcia  Rebekah
- Garcia  Ricardo Rojas
- Garcia  Sonia
- Garibaldi  Matteo
- Garibaldi  Matteo
- Geraldo  Jordana Gonçalves
- Giacomelli  Elena
- Gibson  Tamar
- Gilchrist  James
- Gili  Gisela
- Glenn  Melanie
- Golden  Laura
- Gollogly  Jakit
- Gong  Hui
- Gonzalez  Alejandro Tobon
- Gonzalez  Anna
- Gonçalves  Luiz Otavio Maia
- Gori  Maria
- Goyal  Namita
- Goyal  Neelam
- Guerreiro  Alexandre
- Guingrich  Sandra
- Guptill  Jeffrey
- Gutiérrez  Luis Antonio Querol
- Gutmann  Laurie
- Gutmann  Ludwig
- Haar  Laura
- HaferâMacko  Charlene
- Harbo  Thomas
- Harrison  Tuula
- Hart  Adam
- Harvey  Brittany
- Hasuike  Tomoya
- Hayashi  Takashi
- Hehir  Michael
- Henderson  Kendrick
- Herbelin  Laura
- Herbert  Carol
- Hewlett  Jasmine
- Hietala  Albert
- Higuchi  Eriko
- Hisahara  Shin
- Ho  Doreen
- HobsonâWebb  Lisa
- HomedesâPedret  Christian
- Hong  YoonâHo
- Hopkins  Steve
- Horvath  Melinda
- Howard  James
- Hoyle  Joseph Chad
- Huynh  Kristin
- Hwang  Eun Bi
- Hwang  Ji Ye
- HÞjgaard  Joan
- Illa  Isabel
- Imai  Tomihiro
- Imai  Tomihiro
- Inghilleri  Maurizio
- Iorio  Raffaele
- Ishiyama  Naoko
- Ishiyama  Yoko
- Jacob  Saiju
- Jakab  Gedeonne
- Jara  Jordan
- Jeffery  Dennis
- Jenci  Nicole
- Jeong  HaâNeul
- Jerath  Nivedita
- Jingu  Maki
- Johns  Kathryn
- Jones  Floyd
- Jones  H. James
- Juel  Vern
- Jung  Jin Woo
- Junkerova  Jana
- Jurajdova  Ivana
- Kamakura  Sachiko
- Kamegamori  Ikuko
- Kanai  Tetsuya
- Kaneko  Yoko
- Kang  Hoo Nam
- Kanzaki  Akiko
- Karam  Chafic
- Karam  Chafic
- Karimi  Sanaz
- Katz  Jonathan
- Katzin  Lara
- Kaur  Harpreet
- Kawaguchi  Naoki
- Kawamata  Jun
- Kawamura  Tomohiro
- Kazamel  Mohamed
- Kelley  Andrea
- Keung  Benison
- Khoury  Julie
- Kikutake  Keiko
- Kim  Bryan
- Kim  Byoung Joon
- Kim  ByungâJo
- Kim  Miri
- Kim  Seung Min
- Kim  Yoolâhee
- Kincaid  John
- Kissel  John
- Kobashikawa  Tomomi
- Kobayashi  Eri
- Kobayashi  Hisako
- Koga  Megumi
- Koh  Da Yoon
- Kohlrus  Stephanie
- Koning  Kathy
- Konyane  Monika
- Koo  Dae Lim
- Koo  Yong Seo
- Kooi  Anneke
- Kramer  Megan
- Kressin  Nicole
- Krogh  Susanne
- Kumar  Aditya
- Kurihara  Rikako
- Kurkova  Barbora
- Kutlu  Ayse
- Kwan  Justin
- Kwon  Ju Young
- Laaksonen  Mikko
- Lazaro  Ana
- Lee  Chang Nyoung
- Lee  Hye Lim
- Lee  Hyung Seok
- Lee  Ji Eun
- Lim  JaeâSung
- Lin  Frank
- Lino  Valeria Cavalcante
- Liu  Tina
- Liu  Ye
- Locatelli  Alberta
- Locheke  Jerry
- Lokaitis  Barbara
- Loor  John
- Lopergolo  Diego
- Lovas  Gabor
- Lu  Liang
- Lucy  Shannon
- Macagnan  Ana Paula
- Maeda  Yasuko
- Maggi  Lorenzo
- MahdiâRogers  Mohamed
- Mahieu  Délphine
- Maier  Gal
- Malekniazi  Ali
- Mallon  Ashley
- Mantegazza  Renato
- Maqsood  Fatima
- Marano  Enrico
- Marburger  Tessa
- Marsili  Angela
- Martins  Maurer Pereira
- Masaki  Katsuhisa
- Massey  Janice
- Mathew  Veena
- Matolcsi  Judit
- Matsuse  Dai
- Matsushita  Takuya
- Mazia  Claudio Gabriel
- Mazuela  Gonzalo
- McClain  Terry
- McClain  Terry
- McKenna  Kaitlyn
- McKinnon  Jonathan
- McKinnon  Naya
- McVey  April
- Meguro  Fumie
- Meherremova  Arzu
- Melo  Ana Paula
- Mercelis  Rudy
- Mezache  Louisa
- Micheels  Angela
- Michon  SaraâClaude
- Miller  Robert
- Min  JuâHong
- Minton  Brian
- Miranda  Carolina
- Miyawaki  Eriko
- Miyazaki  Teiichiro
- Mizugami  Aya
- Mogensen  Anita
- Mohr  Henrique
- Mori  Masahiro
- Morikawa  Miyuki
- Morino  Stefania
- Mosmiller  Betsy
- Motomura  Masakatsu
- Mozaffar  Tahseen
- Muharrem  Filiz
- Mukaino  Akihiro
- MumfreyâThomas  Sandi
- Muppidi  Srikanth
- Murahara  Takashi
- Murai  Hiroyuki
- Nagane  Yuriko
- Nakamori  Masayuki
- Nakamura  Yumiko
- Nance  Christopher
- Narayan  Jeffrey
- Narikawa  Koichi
- Nations  Sharon
- Naunton  Kerry
- Nemeth  Joanne
- Norwood  Fiona
- Noshiro  Mayuko
- Novakova  Iveta
- Nowak  Richard J
- Nozaki  Kenkichi
- Nye  Joan
- O'Brien  Fanny
- Oksaranta  Olli
- Okumura  Meinoshin
- Olalde  Heena
- Oliveira  Acary Souza Bulle
- Onar  Musa Kazim
- Onesti  Emanuela
- Orsel  Gulsah
- Osakada  Kaori
- Ozawa  Yukiko
- Ozcelik  Pinar
- Padilla  Patricia
- Paiva  Gabriel
- Palacios  Natalia Julia
- Park  Sang Ae
- Pasanisi  Maria
- Pascuzzi  Robert
- Pasnoor  Mamatha
- Patrick  Kara
- Patti  Francesco
- Patwa  Huned
- Paulose  Shirley
- Pazetto  Lucas Eduardo
- Pedersen  Jane
- Penha Ananias Morita  Maria
- Phan  Cecile
- Piehl  Fredrik
- Pillai  Rekha
- Pineda  Colleen
- Pinto  Graziela
- Pinto  Wladimir
- Pitha  Jiri
- Plevka  Sarah
- Pol  Sabrina
- Polaka  Krishna
- Porras  Laura Diez
- Pozo  Marina
- Prando  Natalia
- Pulley  Michael
- Puorro  Giorgia
- Ra  Hye Jin
- Reguliova  Katarina
- Reyes  Eliana
- Ribeiro  Renata Martins
- Rico  Gabrielle
- Rivera  Francisco Javier Rodriguez
- Robeson  Kimberly
- Rocha  Rosana
- Roderus  Rikki
- Roe  Kristen
- Rosa  Bruno Bezerra
- Rosenfeld  Jeffrey
- Roy  Gulmohor
- Rozsa  Csilla
- Rugiero  Marcelo
- Ruiz  Pedro Lopez
- Saba  Juliet
- SaccĂ Â Francesco
- Sadalage  Girija
- Saito  Yuka
- Saitoh  Masaki
- Sakamuri  Sarada
- Saklad  Amy
- Salajegheh  Mohammed
- Salcedo  Pilar Gomez
- Samukawa  Makoto
- Sanjak  Mohammad
- Sanjak  Mohammed
- Sano  Yoshiko
- Santamaria  Valentina Velez
- Sastre  Maria
- Sathasivam  Sivakumar
- Sato  Miwako
- Sattar  Nadia
- Scala  Stephanie
- Schommer  Clara
- Schotte  Caroline
- Scott  Tierney
- Seddigh  Arshira
- Seelbach  Jenna
- Semiz  Cansu
- Sen  Sedat
- Sengun  Ihsan
- Seok  Hung Youl
- Seok  Jinmyoung
- Shabbir  Yasmeen
- Shabbir  Yasmeen
- Shah  Akshay
- Shah  Amna
- Shah  Jaimin
- Sharma  Khema
- Sheldon  Danielle
- Shimohama  Shun
- Shimohama  Shun
- Shimpo  Misa
- Shin  Chae Won
- Shin  Ha Young
- Shin  Miju
- Shiraishi  Hirokazu
- Siddiqi  Zaeem A
- Sieren  Jeri
- Silva  Liene Duarte
- Silva  Luiz Augusto
- Silva  Marcela
- Silva  Tamires Cristina Gomes
- Silvestri  Nicholas
- Siqueira Carvalho  Alzira Alves
- Smetcoren  Charlotte
- Smith  Lisa
- Snook  Riley
- So  Yuen T
- Sohail  Faisal
- Sokratous  Giannis
- Souza  Iandra
- Srinivasan  Jayashri
- Statland  Jeffery
- Steele  Julie
- Stevens  Olivier
- Strom  Susan
- Sune  Pilar
- Suzuki  Hidekazu
- Suzuki  Shuichiro
- Suzuki  Yasushi
- Swenson  Andrea
- Szabadosne  Brigitta
- Szabo  Gyorgyi
- Taichi  Namie
- Takada  Kazumi
- Takada  Mihoko
- Takahashi  Masanori
- Takeyama  Rumi
- Tandan  Rup
- Tano  Ohito
- Tejedor  Exuperio Diez
- Terzi  Murat
- the REGAIN Study Grp
- Tilkin  Petra
- Toncrova  Stanislava
- Torane  Pravin
- Torres  Debora Dada Martineli
- Toska  Shirli
- Tran  Anh
- Traub  Rebecca
- Trivedi  Jaya
- Troili  Fernanda
- Tsuda  Emiko
- Tsuda  Tomoko
- Tsukita  Kenichi
- Tsurumaru  Masako
- Tuga  Celal
- Tun  Ozlem
- Tyblova  Michaela
- Uehara  Taira
- Ugur  Muzeyyen
- Utsugisawa  Kimiaki
- Uwasa  Kaori
- Uzawa  Akiyuki
- Van Daele  Sien
- Van Damme  Philip
- Van den Abeele  Guy
- Vandenbussche  Nicolas
- Vanderhook  Mollie
- Vanhee  Annelies
- Varga  Edina
- Varghese  Mary
- Vecsei  Laszlo
- Veiga  Thabata
- Ventura  Nicholas
- Verjans  Sarah
- Veske  Adife
- Vicente  Elena Cortes
- Vidal  Gonzalo
- Vidal  Nuria
- Vinge  Lotte
- Visser  Marianne
- Vissing  John
- Vohanka  Stanislav
- Volpe  Luciana Renata Cubas
- Vu  Hong
- Vu  Tuan
- Vynckier  Jan
- Vytopil  Michal
- Wagemaekers  Linda
- Waheed  Waqar
- Walsh  Maureen
- Wang  Yunxia
- Watling  Dave
- Watt  Elizabeth
- Weiner  Elaine
- Weiss  Michael
- Welsh  Lesly
- Wheeler  Lauren
- Wilken  Miguel
- Wilken  Miguel
- Witting  Nanna
- Wolfe  Gil
- Wolfova  Marcela
- Woodall  Amy
- Yamamoto  Daisuke
- Yamashita  Yumi
- Yang  Irene
- Yasuda  Ikuko
- Yilmaz  Ezgi
- Yoshida  Seiko
- Yoshida  Seiko
- Yoshimura  Shunsuke
- Young  Valerie
- Yountz  Marcus
- Zakalik  Karen
- Zapletalova  Olga
- Zilliox  Lindsay
- Publication venue
- John Wiley & Sons, Inc
- Publication date
- 01/12/2021
- Field of study
Introduction/Aims
Individuals with refractory generalized myasthenia gravis (gMG) who have a history of rituximab use and experience persistent symptoms represent a population with unmet treatment needs. The aim of this analysis was to evaluate the efficacy and safety of eculizumab in patients with refractory antiâacetylcholine receptor antibodyâpositive (AChR+) gMG previously treated with rituximab.
Methods
This post hoc subgroup analysis of the phase 3 REGAIN study (NCT01997229) and its openâlabel extension (OLE; NCT02301624) compared baseline characteristics, safety, and response to eculizumab in participants who had previously received rituximab with those who had not. Rituximab use was not permitted within the 6âmonths before screening or during REGAIN/OLE.
Results
Of 125 REGAIN participants, 14 had received rituximab previously (7 received placebo and 7 received eculizumab). In the previousârituximab group, 57% had used at least four other immunosuppressants compared with 16% in the noâpreviousârituximab group. Myasthenia Gravis Activities of Daily Living total scores from eculizumab baseline to week 130 of eculizumab treatment improved in both the previousârituximab and noâpreviousârituximab groups (leastâsquares mean â4.4, standard error of the mean [SEM] 1.0 [n = 9] and leastâsquares mean â4.6, SEM 0.3 [n = 67], respectively; difference = 0.2, 95% confidence interval â1.88 to 2.22). In addition, in both groups, most patients who were treated with eculizumab for 130âweeks achieved a Myasthenia Gravis Foundation of America postâintervention status of minimal manifestations (66.7% and 65.0%, respectively). The eculizumab safety profile was similar between groups and consistent with its established profile.
Discussion
Eculizumab is an effective therapy for patients with refractory AChR+ gMG, irrespective of whether they had received rituximab treatment previously
Correction to: Eculizumab improves fatigue in refractory generalized myasthenia gravis (Quality of Life Research, (2019), 28, 8, (2247-2254), 10.1007/s11136-019-02148-2)
- Author
- Acar Nazire Pinar
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alberti Aguilo Maria Antonia
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amaral Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis NatĂĄlia
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsar
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Butinhao Cristiani Fernanda
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Choi Eun Hwa
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cunningham Scott
- CĂ©sar Pamela
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- da Silva Luiz Augusto
- Depreitere Annelies
- Dezsi Livia
- de Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- de Mey Katrien
- de Visser Marianne
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- di Pasquale Antonella
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- DâAmato Valentina
- DâHondt Ann
- Echevarria Laura
- Efendi Husnu
- Elsayed Mona
- Emmons Kelley
- Engel Marguerite
- Eralinna Juha-Pekka
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernandes Patricia
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Fialho TomĂĄs Augusto Suriane
- Filla Allessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriele Maria
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gheller Friedrich MaurĂcio AndrĂ©
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guingrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Hendersen Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard James F.
- Hoyle Joseph Chad
- Huynh Kristin
- Hwang Eun Bi
- Hwang Ji Ye
- HĂžjgaard Joan
- Illa Isabel
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- Jara Jordan
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Jones H. James
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byoung Joon
- Kim Byung-Jo
- Kim Miri
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koh Da Yoon
- Kohlrus Stephanie
- Konyane Monika
- Koo Dae Lim
- Koo Yong Seo
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kurkova Barbora
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee Chang Nyoung
- Lee HyeLim
- Lee Hyung Seok
- Lee JiEun
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Macagnan Ana Paula
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu D. lphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martineli Torres Debora Dada
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazia Claudio Gabriel
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Melo Ana Paula
- Mercelis Rudy
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onar Musa Kazim
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Ostergaard Autzen Anne
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- OâBrien Fanny
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patra Kaushik
- Patrick Kara
- Patwa Huned
- Paulose Shirley
- Pazetto Lucas Eduardo
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pokala Krishna
- Pol Sabrina
- Pozo Marina
- Prando Natalia
- Pulley Michael
- Puorro Giorgia
- Querol Gutierrez Luis Antonio
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Rodriguez de Rivera Francisco Javier
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Roy Gulmohor
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- Rugiero Marcelo
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- Sadalage Girija
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- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
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- Samukawa Makoto
- Sanjak Mohammad
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelback Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimpo Misa
- Shin ChaeWon
- Shin Ha Young
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- So Yuen T.
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Iandra
- Souza Duca Luciana
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
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- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
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- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
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- Tun Ozlem
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- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- van Daele Sien
- van Damme Philip
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- Varghese Mary
- Vecsei Laszlo
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- Ventura Nicholas
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- Vidal Gonzalo
- Vidal Nuria
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- Vu Hong
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- Vytopil Michal
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Jing Jing
- Wang Junxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshimura Shunsuke
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/08/2019
- Field of study
The article âEculizumab improves fatigue in refractory generalized myasthenia gravisâ, written by âHenning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny OâBrien, Kaushik Patra, James F. Howard Jr. and The REGAIN Study Groupâ was originally published electronically on the publisherâs internet portal (currently SpringerLink) on 23 March 2019 without open access
Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19
- Author
- Aalap Chokshi
- Abdelkader Medjahedi
- Abhishek Gupta
- Adam Bernheim
- Adel Allam
- Adelina Sanches
- Adolfo Facello
- Adriana Puente
- Adwait Trivedi
- Afroza Akhter
- Agha Haider
- Ahmad Amro
- Ahmad Ozair
- Ahmed Aljizeeri
- Ahmed Ibrahim
- Ahmed Kandeel
- Ahmed Suliman
- Ajay Vyas
- Albert Flotats
- Alberto Cadena
- Alberto Clemente
- Alberto Cuocolo
- Alberto Gerali
- Alejandro Maldonado
- Alejandro Radzinschi
- Alejandro Zuluaga Santamaria
- Alessandra Scatteia
- Alessia Gimelli
- Alexander Kokov
- Alexandre Volney Villa
- Alexey Ansheles
- Alfredo Rodrigues
- Alia Abdelfattah
- Alicia Camarero
- Alireza Emami-Ardekani
- Aloha Meave
- Alvin Quinon
- Amalia Peix
- Ambedhkar Shantaram Naojee
- Amee Shah
- Amelia Jimenez-Heffernan
- Amit Pursnani
- Amit Sharma
- Amjed Albadr
- Amparo Martinez Monzonis
- Ana Manovel-SaÌnchez
- Ana Teresa Timoteo
- Anastasia Oikonomou
- Anatoliy Karalkin
- Anda Bularga
- Anders Tjellaug BraÌten
- Andor Glaudemans
- Andrea Bruno
- Andrea de Lorenzo
- Andrea Paccagnella
- Andrea Vilela
- Andres Preciado-Anaya
- Andressa Borges
- Andrew Choi
- Andrew Choi
- Andrew J Einstein
- Andrew Tauro
- Andrew Taylor
- Angela Byrne
- Angela Gaudiano
- Animesh Mishra
- Anita Liiver
- Anjali Chelliah
- Anna Baritussio
- Anna Teresinska
- Annette Johnstone
- Anthon Fuisz
- Anthony Samuel
- Anthony Upton
- Antonella Stefanelli
- Antonio CalderoÌn
- Apurva Shrigiriwar
- Apurva Sinha
- Arati Lalchandani
- AristoÌteles RamiÌrez Salazar
- Arjun Ghosh
- Arpakorn Kositwattanarerk
- Artan Goda
- Arturo Romero AcunÌa
- Arve JĂžrgensen
- Arvind Sethi
- Aryeh Shalev
- Asela Bustos-Barroso
- Ashwani Sood
- Attila KovaÌcs
- Atul Verma
- Augusto Almeida
- Awadhesh Kumar Sharma
- Azeem Sheikh
- Azita Moalemi
- Barbara GuzÌic Salobir
- Barry Elison
- Bawinile Hadebe
- BaÌlint Szilveszter
- Belinda San Juan
- Benjamin Hudson
- Benjapa Khiewvan
- Bernadette Lisske
- Bernard Koch
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- Berry Allen
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- Bin Lu
- Binh Duong Duc
- Bjarne L NĂžrgaard
- Brenda Mccullough
- Brian Morrissey
- Caiying Li
- Calum Young
- Cameron Foster
- Camila Flores
- Candace Candela
- Carla Gonzalez
- Carla Sousa
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- Carlo Liguori
- Carlo Tedeschi
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- Carmen Concha
- Carole Dennie
- Caroline M Van De Heyning
- Ceferino Gutierrez Mendiguchia
- Cesar Higa Nomura
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- Chanan Moffitt
- Chen Sheng Low
- Chetan Patel
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- Chunxiang Tang
- Cibele Gontijo
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- Claudia Jaimes
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- Claudio Marcassa
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- Claudio Pereyra Sueldo
- Claudiu Stan
- Clothilde Berger
- Cole B Hirschfeld
- Connor Saunders
- Corrado Cittanti
- Cristina Gavina
- Cristina SebastiaÌo Matushita
- Cuba Juan Felipe Batista
- D'Arne Downie
- Dainia Baugh
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- Damayanthi Nanayakkara
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- Dinesh Kalra
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- Dragana Sobic Saranovic
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- Edward Nicol
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- Ekaterina Migunova
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- Elia GarciÌa
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- Emmy Okello
- Enrique Vallejo
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- Erick AlexaÌnderson-Rosas
- Erik Bieging
- Erika Barragan
- Ernest Madu
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- Haluk Burcak Sayman
- Hamed Zuhairy
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- Vassilis Prassopoulos
- Venkatesh Murthy
- Veronica Della Tommasina
- VeroÌnica Vanesa GoÌmez Leiva
- Victor Hasbani
- Victor JaÌger
- Victor Wayne
- Vijay Sai Chowdekar
- Vikas Tandon
- Vikas Verma
- Viktor Pospelov
- Vincent Sorrell
- Vincenzo Russo
- Virginia Garcia Quinto
- Virginia Pubul
- Vittorio Censullo
- Vivaswan Dutt Mishra
- Vivek Bhat
- Viviana Frantellizzi
- Vladimir Kincl
- Vladimir Sergienko
- Wanda Acampa
- Warren Moore
- Wenya Liu
- William DeSisto
- William Duvall
- William Topping
- Wilson Furlan Matos Alves
- Won Jun Kang
- Ximing Wang
- Xuan Canh Nguyen
- YamileÌ PenÌa
- Yan Yi
- Yang Hou
- Yao Lu
- Yariela Herrera Malo
- Yaroslav Pynda
- Yasmin Hamirani
- Yassine Martinez
- Yasushi Wakabayashi
- Yasutaka Ichikawa
- Yasutoshi Ohta
- Yasuyo Taniguchi
- Yeon-Koo Kang
- Yiannis Chatzizisis
- Yining Wang
- Yoav Arnson
- Yoichi Otomi
- Yong Hyu Jeong
- Yosef Cohen
- Yoshimitsu Fukushima
- Young So
- Younghoon Kwon
- Yu Izawa
- Yunqiang An
- Zabah Jawa
- Zhaoqian Wang
- Zhuoran Xu
- Zorana Mrsic
- Zuzana Berecova
- Publication venue
- Publication date
- 01/01/2022
- Field of study
BACKGROUND The extent to which health care systems have adapted to the COVID-19 pandemic to provide necessary cardiac diagnostic services is unknown.OBJECTIVES The aim of this study was to determine the impact of the pandemic on cardiac testing practices, volumes and types of diagnostic services, and perceived psychological stress to health care providers worldwide.METHODS The International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular diagnostic care at the pandemic's onset and 1 year later. Multivariable regression was used to determine factors associated with procedure volume recovery.RESULTS Surveys were submitted from 669 centers in 107 countries. Worldwide reduction in cardiac procedure volumes of 64% from March 2019 to April 2020 recovered by April 2021 in high- and upper middle-income countries (recovery rates of 108% and 99%) but remained depressed in lower middle- and low-income countries (46% and 30% recovery). Although stress testing was used 12% less frequently in 2021 than in 2019, coronary computed tomographic angiography was used 14% more, a trend also seen for other advanced cardiac imaging modalities (positron emission tomography and magnetic resonance; 22%-25% increases). Pandemic-related psychological stress was estimated to have affected nearly 40% of staff, impacting patient care at 78% of sites. In multivariable regression, only lower-income status and physicians' psychological stress were significant in predicting recovery of cardiac testing.CONCLUSIONS Cardiac diagnostic testing has yet to recover to prepandemic levels in lower-income countries. Worldwide, the decrease in standard stress testing is offset by greater use of advanced cardiac imaging modalities. Pandemic-related psychological stress among providers is widespread and associated with poor recovery of cardiac testing. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
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- Bahram Seiamak
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- Ramaswamy Sathishkumar
- Rambaud Thomas
- Ramirez-Santana Carolina
- Ramos Miquel Alfonso
- Raoult Didier
- Raoult Didier
- Raoult Violette
- Rapti Vasiliki
- Rausell Antonio
- Rebillat Anne-Sophie
- Reddy Conor
- Redin Claire
- Reijnders Tom
- Renia Laurent
- Resmini LĂ©a
- Resnick Igor
- Reyes Luis Felipe
- Ricart Pilar
- Ricaurte Oscar Andrés Briceño
- Rice Charles
- Richard Jean-Christophe
- Richard Lucie
- Richard Pascale
- Richard Pascale
- Rieux-Laucat Frédéric
- Rigo-Bonnin RaĂșl
- Rigo-Bonnin RaĂșl
- Rivet Nadia
- RiviĂšre Jacques
- RiviĂšre Jacques
- Rocamora-Blanch Gemma
- Rodero Mathieu
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero AgustĂ
- RodrĂguez Yhojan
- RodrĂguez-Gallego Carlos
- RodrĂguez-Gallego Carlos
- Rogge Lars
- Rojas Manuel
- Rojas-Villaraga Adriana
- Romero Carolina Soledad
- Rosa-Calatrava Manuel
- Rosain Jérémie
- Rosen Lindsey
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rothenbuhler Anya
- Roufai Layidé
- Roussel Lucie
- Roux Damien
- Rovina Nikoletta
- Rowen Lee
- Roy Carine
- Rozenberg Flore
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabater-Riera Joan
- Sahanic Sabina
- Saker Kahina
- Saks Kai
- Sakuntabhai Anavaj
- Salagianni Maria
- Sallette JĂ©rĂŽme
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Schidlowski Laire
- Schinkel Michiel
- Schluter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke
- Schuetz Catharina
- Schultz Marcus
- Schuurman Alex
- Schuurmans Jaap
- Schwartz Olivier
- Schweitzer Cyril
- Schwikowski Benno
- Scolari Francesco
- Sediva Anna
- Sediva Anna
- Sedkaoui Souad Mehlal
- Seeleuthner Yoann
- Seijo Luis
- Seminario Analia Gisela
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- SeppÀnen Mikko
- SeppÀnen Mikko R.J.
- Shahrooei Mohammad
- Shahrooei Mohammed
- Sharif-Askari Fatemeh Saheb
- Shaw Elana
- Shcherbina Anna
- Shcherbina Anna
- Shcherbina Anna
- Shorte Spencer
- Sigaloff Kim
- Siguret Virginie
- Siouti Eleni
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen
- Smadja David
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snow Andrew
- Snow Andrew
- Sobh Ali
- Solanich Xavier
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-PalacĂn Pere
- Soler-PalacĂn Pere
- Solis Blanca Garcia
- Solé-Violån Jordi
- Solé-Violån Jordi
- Sottini Alessandra
- Soumaré Aïcha
- Spaan AndrĂĄs
- Spaan AndrĂĄs
- Stella Giulia Maria
- Stepanian Alain
- Stepanovskiy Yuriy
- Stepanovskyy Yurii
- Stijnis Cornelis
- Stilma Willemke
- Stoclin Annabelle
- Storgaard Merete
- Su Helen
- Su Helen
- Su Richa
- Susen Sophie
- Syrigos Konstantinos
- SĂĄnchez-MontalvĂĄ AdriĂĄn
- SĂĄnchez-RamĂłn Silvia
- SĂ€rekannu Karita
- Sözeri BetĂŒl
- SĂžrensen Erik
- Taccone Fabio
- Talouarn Estelle
- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Tharaux Pierre-Louis
- Thibault Chloé
- Thiery Guillaume
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiberghien Pierre
- Tiberghien Pierre
- Timsit Jean-François
- Tipu Imran
- Tolstrup Martin
- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
- Townsend Liam
- Triantafyllia Vasiliki
- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya JesĂșs
- Troya JesĂșs
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population