24 research outputs found
Design and evaluation of dry-coated tablets for colonic delivery of diclofenac sodium
A colonic drug delivery system is required to protect a drug during its transit through the upper gastro-intestinal tract and allow its release in the colon. The aim of this study was the preparation of dry-coated tablets designed for colonic release of the model drug Diclofenac sodium (DS). The system consists of a drug-pectine (PC) mixture as the core and hydroxypropylmethylcellulose (HPMC) alone or mixed in different ratios with poly(ε-caprolactone) (CL) as the coat layer
Resveratrol-loaded nanoparticles based on polymeric blend for prostsate cancer treatment
The trans-resveratrol (RSV) has been reported to act as an antiproliferative and chemopreventive agent against a wide variety of tumors, including prostate cancer (PCa)I,2. Nanoencapsulation of RSV represents a powerful strategy to provide protection of degradation, enhancement of
bioavailability, improvement of intracellular penetration and control delivery,4.
We developed novel polymeric nanoparticles (NPs) encapsulating RSV (nano-RSV), based on a polymeric blend, as effective prototypes for PCa treatment. Our results support the potential use of these prototypes for the controlled delivery ofRSV for PCa treatment
Targeted nanoparticles for the delivery of novel bioactive molecules to pancreatic cancer cells
Pancreatic cancer (PaCa) is a multifaceted disorder with an extremely poor prognosis. There is an urgent need to identify new and safe drugs as well as to develop novel
tumor-targeted controlled release systems for effective treatment of late stage and resistant PaCa. Active targeting via the inclusion of specific ligands on the nanoparticles (NPs) is envisioned to provide a powerful therapeutic strategy.
Herein, we present a study on the design and the development of novel DFCencapsulated biocompatible polymeric NPs, functionalized with peptides to selectively
bind to Plec-1 (PTP), or densely decorated by low molecular weight organic molecules as alternative targeting ligands (2-ABA), and evaluated a) the impact on ligand binding
and b) the in vitro antiproliferative efficacy against a panel of PaCa cells
Microencapsulation of <i>Bacillus thuringiensis</i> and insecticidal activity evaluation on larvae of lepidoptera
Bacillus thuringiensis (Bt) is one of the bacterial entomopathogens most frequently studied as a
toxin producer. Its insecticidal activity was attributed to the parasporal crystals formed during the
stationary phase of its growth cycle, and released during sporulation. The efficacy of Bt is highly
sensitive to the environmental conditions; when exposed to UV light, the insecticidal proteins
undergoes to rapid degradation.
Considerable research has attempted to improve Bt field persistence using ultraviolet absorbers,
encapsulation and addition of clay granules to spray formulations.
The aim of this study was to investigate different encapsulation processes in order to obtain the
Bt-based formulations consisting of matrix-type microcapsules
<i>In vitro</i> and <i>in vivo</i> studies of artichoke extract (<i>Cynara scolymus</i> L.) as ketoprofen skin penetration enhancer
In this study, the enhancing effect of artichoke extract containing cynaropicrin on the in
vitro and in vivo percutaneous absorption of ketoprofen from gels has been investigated
Evaluation of the vehicle effect on release of diphenhydramine hydrochloride from topical formulations: in vitro and in vivo preliminary studies
Diphenhydramine hydrochloride (DPH) is a histamine H1-receptor antagonist, widely used as
antiallergic, antiemetic and antitussive drug in many pharmaceutical preparations. The aim of this study was to evaluate the vehicle effect on in vitro diffusion of DPH from new
five topical formulations: microemulsion, microemulsion+silica, Na Alginate emulgel, Carbopol cream and hydroxyethylcellulose gel
Spray-dried microspheres based on methylpyrrolidinone chitosan: <i>in-vitro</i> and <i>ex-vivo</i> studies
The purpose of this work was the preparation and the study of methypyrrolidinone chitosan spray-dried microspheres for the intranasal release of metoclopramide hydrochloride (Met). Chitosan (CH) microparticles were prepared as comparison
<i>Ex vivo</i> cutaneous penetration of econazole nitrate from SLN incorporated in hydrophilic gels
Solid lipid nanoparticles (SLN) are considered as innovative drug carrier for topical
application. The small size of the lipid particles ensures close contact to the stratum
corneum and can increase the amount of the drug penetrating into the skin and it allows
controlled drug release.
The aim of this study was to develop controlled release gels containing SLN dispersions
loaded with Econazole Nitrate (ECN) and to evaluate ex vivo skin penetration of the drug
released from the particles
Study of hydrogels based on polyacrilamide as new controlled release dosage forms produced by frontal polymerization
The work purpose was the evaluation of the potential application of the Frontal
Polymerization (FP) technique as a new method for the preparation of controlled release
dosage forms based on polyacrilamide, in which the drug loading and the polymer
preparation occur at the same time
Docking ligando-DNA e validazione della capacitĂ intercalante di nuovi derivati "two-armed"
In questo contesto è risultato di grande interesse cercare di studiare la capacità intercalante
e le modalitĂ di binding di noti ligandi (Actinomicina D, Etidio bromuro, Distamicina)
attraverso uno studio computazionale con tecniche di docking che potesse risultare di utile
supporto nella ricerca di nuovi agenti intercalanti. E’ stato quindi messo a punto un
versatile metodo di docking tramite l’utilizzo del programma AutoDock operando in
diverse condizioni sperimentali