Are aggressive deliveries of very preterm babies justified?

Background: Every year there are 15 million babies who are born too soon. The objective of this study was to analyze the neonatal morbidity and mortality of preterm neonates at birth.Methods: This was a prospective study conducted in the department of obstetrics and gynecology and neonatology. We included all preterm deliveries from 26 weeks to 36 weeks 6 days period of gestation in one year. Neonatal morbidities and mortalities at birth were noted.Results: The rate of preterm birth was 8.49%. Spontaneous preterm labor accounted for 52% of the causes of preterm. Hyperbilirubinemia was the commonest neonatal morbidity affecting 53.2% of the neonates. Respiratory distress syndrome (RDS) and sepsis was highest in neonates of 26 weeks to 28 weeks gestation. This group saw a mortality of 90%.Conclusions: Prematurity is associated with high mortality and long-term morbidity. Low APGARS might be good predictors of neonatal/ infant mortality.  In the extremely preterm neonate, it may prove worthy to weigh the risks and benefits and thereafter counsel the mother and concerned relatives accordingly to help with decision making.

Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma

We previously reported the remarkable potency of uttroside B (Utt-B), saponin-isolated and characterized in our lab from Solanum nigrum Linn, against HCC. Recently, the U.S. FDA approved Utt-B as an ‘orphan drug’ against HCC. The current study validates the superior anti-HCC efficacy of Utt-B over sorafenib, the first-line treatment option against HCC. The therapeutic efficacies of Utt-B vs. sorafenib against HCC were compared in vitro, using various liver cancer cell lines and in vivo, utilizing NOD.CB17-Prkdcscid/J mice bearing human HCC xenografts. Our data indicate that Utt-B holds an augmented anti-HCC efficacy over sorafenib. Our previous report demonstrated the pharmacological safety of Utt-B in Chang Liver, the normal immortalized hepatocytes, and in the acute and chronic toxicity murine models even at elevated Utt-B concentrations. Here, we show that higher concentrations of sorafenib induce severe toxicity, in Chang Liver, as well as in acute and chronic in vivo models, indicating that, apart from the superior therapeutic benefit over sorafenib, Utt-B is a pharmacologically safer molecule, and the drug-induced undesirable effects can, thus, be substantially alleviated in the context of HCC chemotherapy. Clinical studies in HCC patients utilizing Utt-B, is a contiguous key step to promote this drug to the clinic

Proceedings of International Web Conference in Civil Engineering for a Sustainable Planet

This proceeding contains articles of the various research ideas of the academic community and practitioners accepted at the "International Web Conference in Civil Engineering for a Sustainable Planet (ICCESP 2021)". ICCESP 2021 is being Organized by the Habilete Learning Solutions, Kollam in Collaboration with American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India. Conference Title: International Web Conference in Civil Engineering for a Sustainable PlanetConference Acronym: ICCESP 2021Conference Date: 05–06 March 2021Conference Location: Online (Virtual Mode)Conference Organizer: Habilete Learning Solutions, Kollam, Kerala, IndiaCollaborators: American Society of Civil Engineers (ASCE), TKM College of Engineering, Kollam, and Baselios Mathews II College of Engineering, Kollam, Kerala, India