Acute central serous chorioretinopathy — an uncommon complication of imatinib mesylate (imatinib) therapy in chronic myelogenous leukaemia

Imatinib is the most widely used drug in targeted therapy for chronic myelogenous leukaemia (CML). Few ophthalmic side effects like periorbital oedema, epiphora, ptosis, extraocular muscle palsy, blepharoconjunctivitis, glaucoma, papilledema, photosensitivity, retinal haemorrhage, and increased intraocular pressure are described with imatinib therapy. A 35-year-old male, a known case of CML with no ocular complaints, on treatment with imatinib for the preceding six weeks, presented with acute central serous chorioretinopathy in the left eye. Owing to his professional requirements for early visual recovery, he was treated with subthreshold micropulse laser with complete resolution of the subretinal fluid. This case report highlights acute central serous chorioretinopathy as a potential rare complication of imatinib therapy in CML patients, which requires regular and detailed ophthalmic evaluation so as to diagnose and treat it without any residual effects

Structural Basis for the Anomalously Low Spontaneous Polarisation Values of the Polar Phase of Sr1-xCaxTiO3 (x=0.02, 0.04): Evidence for a Ferrielectric Ordering

Full pattern Le-Bail refinement using x-ray powder diffraction profiles of Sr1-xCaxTiO3 for x=0.02, 0.04 in the temperature range 12 to 300 K reveals anomalies in the unit cell parameters at 170, 225 K due to an antiferrodistortive (cubic to tetragonal I4/mcm) phase transition and at ~32, ~34 K due to a transition to a polar phase (tetragonal I4/mcm to orthorhombic Ic2m), respectively. The lower transition temperatures obtained by us are in excellent agreement with those reported on the basis of the dielectric studies by Bednorz and Muller, [10] who attributed these to ferroelectric transition. Rietveld analysis of the diffraction profiles of the polar phase reveals off-centre displacements of both Sr2+/Ca2+ and Ti4+ ions in the X-Y plane along pseudocubic directions, in agreement with the experimentally reported direction of easy polarization by Bednorz and Muller, but the resulting dipole moments are shown to be ferrielectrically coupled in the neighbouring (001) planes along the [001] direction leading to anomalously low values of the spontaneous polarization at 12K.Comment: 5 pages, 4 figures and 1 tabl

Statistical Mechanics of DNA unzipping under periodic force: Scaling behavior of hysteresis loop

A simple model of DNA based on two interacting polymers has been used to study the unzipping of a double stranded DNA subjected to a periodic force. We propose a dynamical transition, where without changing the physiological condition, it is possible to bring DNA from the zipped/unzipped state to a new dynamic (hysteretic) state by varying the frequency of the applied force. Our studies reveal that the area of the hystersis loop grows with the same exponents as of the isotropic spin systems. These exponents are amenable to verification in the force spectroscopic experiments.Comment: Accepted for publication in Physical Review Letter

Dynamical phase transition of a periodically driven DNA

Replication and transcription are two important processes in living systems. To execute such processes, various proteins work far away from equilibrium in a staggered way. Motivated by this, aspects of hysteresis during unzipping of DNA under a periodic drive in non-equilibrium conditions are studied. A steady state phase diagram of a driven DNA is proposed which is experimentally verifiable. As a two state system, we also compare the results of DNA with that of an Ising magnet under an asymmetrical variation of magnetic field.Comment: 8 pages, 6 figures, Accepted version in PR

A New Type of Coincidence and Common Fixed-Point Theorems for Modified ð-Admissible ð©-Contraction Via Simulation Function

In this manuscript, we introduce the concept of modified α-admissible contraction with the help of a simulation function and use this concept to establish some coincidence and common fixed-point theorems in metric space. An illustrative example that yields the main result is given. Also, several existing results within the frame of metric space are established. The main theorem was applied to derive the coincidence and common fixed-point results for α-admissible ð’µ-contraction

Functional and radiological outcomes of intertrochanteric fractures treated with proximal femoral nail

Background: Hip fracture is one of the most invalidating diseases affecting geriatric populations and in fall related fractures, they lead to most severe morbidity and mortality. Their surgical treatment allows stable fracture fixation which allows the early weight bearing. Many devices have been developed, yet mechanical failures still occur. The aim of this study was to assess the functional and radiological outcomes of intertrochanteric fractures treated with proximal femoral nail.Methods: 46 patients with intertrochanteric fractures fixed with proximal femoral nail were assessed. Functional outcome was measured by Harris hip score (HHS) and lower extremity functional scale (LEFS) and radiological outcome was measured by tip apex distance (TAD), any changes in neck shaft angle, neck length and the offset as compared to uninjured hip.Results: The tip apex distance on the postoperative X-ray was found to be 22.02±2.499 mm, change in the neck length as compared to the uninjured hip was found to be 1.507±1.1808 and change in the offset and neck shaft angle was 1.470±1.0126 and -1.602±1.5992 respectively. The LEFS was found to be 70.63±6.584 whereas the HHS was found to be 90.35±7.593Conclusions: With the increase in TAD the functional and radiological outcome worsens. It was also seen that the cutoff of 25 mm stands true in predicting the outcome of the patients with PFN in intertrochanteric fractures. Hence, the TAD should be routinely measured and if found more than 25 mm then proper precautions like delayed weight bearing may be advised