Positive periodic solutions for a neutral delay ratio-dependent predatorprey model with a Holling type II functional response, Nonlinear Anal.RWA

By using a continuation theorem based on coincidence degree theory, we establish some easily verifiable criteria for the existence of positive periodic solutions for neutral delay ratio-dependent predator-prey model with Holling-Tanner functional response x t x t r t − a t x t − σ t − b t x t − σ t − c t x t y t / h t y t x t , y t y t d t − f t y t − τ t /x t − τ t

Positive Periodic Solutions for Neutral Delay Ratio-Dependent Predator-Prey Model with Holling-Tanner Functional Response

By using a continuation theorem based on coincidence degree theory, we establish some easily verifiable criteria for the existence of positive periodic solutions for neutral delay ratio-dependent predator-prey model with Holling-Tanner functional response x'(t)=x(t)[r(t)-a(t)x(t-σ(t))-b(t)x'(t-σ(t))]-c(t)x(t)y(t)/h(t)y(t)+x(t), y'(t)=y(t)d(t)-f(t)y(t-τ(t))/x(t-τ(t))

Liquid Metal-Based Epidermal Flexible Sensor for Wireless Breath Monitoring and Diagnosis Enabled by Highly Sensitive SnS2 Nanosheets

Real-time wireless respiratory monitoring and biomarker analysis provide an attractive vision for noninvasive telemedicine such as the timely prevention of respiratory arrest or for early diagnoses of chronic diseases. Lightweight, wearable respiratory sensors are in high demand as they meet the requirement of portability in digital healthcare management. Meanwhile, high-performance sensing material plays a crucial role for the precise sensing of specific markers in exhaled air, which represents a complex and rather humid environment. Here, we present a liquid metal-based flexible electrode coupled with SnS2 nanomaterials as a wearable gas-sensing device, with added Bluetooth capabilities for remote respiratory monitoring and diagnoses. The flexible epidermal device exhibits superior skin compatibility and high responsiveness (1092%/ppm), ultralow detection limits (1.32 ppb), and a good selectivity of NO gas at ppb-level concentrations. Taking advantage of the fast recovery kinetics of SnS2 responding to H2O molecules, it is possible to accurately distinguish between different respiratory patterns based on the amount of water vapor in the exhaled air. Furthermore, based on the different redox types of H2O and NO molecules, the electric signal is reversed once the exhaled NO concentration exceeds a certain threshold that may indicate the onset of conditions like asthma, thus providing an early warning system for potential lung diseases. Finally, by integrating the wearable device into a wireless cloud-based multichannel interface, we provide a proof-of-concept that our device could be used for the simultaneous remote monitoring of several patients with respiratory diseases, a crucial field in future digital healthcare management

Ultrasonic‐Enabled Nondestructive and Substrate‐Independent Liquid Metal Ink Sintering

Abstract Printing or patterning particle‐based liquid metal (LM) ink is a good strategy to overcome poor wettability of LM for its circuits’ preparation in flexible and printed electronics. Subsequently, a crucial step is to recover conductivity of LM circuits consisting of insulating LM micro/nano‐particles. However, most widely used mechanical sintering methods based on hard contact such as pressing, may not be able to contact the LM patterns' whole surface conformally, leading to insufficient sintering in some areas. Hard contact may also break delicate shapes of the printed patterns. Hereby, an ultrasonic‐assisted sintering strategy that can not only preserve original morphology of the LM circuits but also sinter circuits on various substrates of complex surface topography is proposed. The influencing factors of the ultrasonic sintering are investigated empirically and interpreted with theoretical understanding by simulation. LM circuits encapsulated inside soft elastomer are successfully sintered, proving feasibility in constructing stretchable or flexible electronics. By using water as energy transmission medium, remote sintering without any direct contact with substrate is achieved, which greatly protect LM circuits from mechanical damage. In virtue of such remote and non‐contact manipulation manner, the ultrasonic sintering strategy would greatly advance the fabrication and application scenarios of LM electronics

Therapeutic Effects of Hydrogen-Rich Solution on Aplastic Anemia in Vivo

Background: Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) secreted by autologous T cells are closely related with the development of AA. Hydrogen-rich solution was reported to inhibit the levels of cytokines including INF-γ, TNF-α and IL-6 in vivo in recent studies. This study was to investigate the potential therapeutic effects of hydrogen-rich solution on AA in vivo. Methods: AA model was determined in vivo by mice and body weights of the mice were used as the basic physiological index. Peripheral blood cells were calculated to evaluate the hematologic recovery degree. Bone marrow nucleated cells (BMNCs), tissue histology, as well as CFU-S and CFU-GM forming units were used to evaluate the recovery of bone marrow microenvironment. The ratio of CD4+ and CD8+ cells were examined along with cytokine levels in serum to determine the efficacy of H2-rich solution on the affected immunological functions. Results: Body weight and number of peripheral blood cells were significantly improved for mice in the H2-rich solution treated groups as compared with those with AA. The number of BMNCs and CFUs increased markedly and the bone marrow microenvironment was also improved significantly. The experimental group restrained the cell apoptosis, relieved hyperemia and accelerated tissue repair. The number of CD4+ and CD8+ cells as well as the ratio of CD4/CD8 increased to normal gradually, while the levels of TNF-α, IFN-γ, and IL-6 in serum decreased after H2-rich solution treatment. Conclusion: Our study firstly showed that hydrogen-rich solution accelerated the recovery of either hematological or immunological recovery on aplastic anemia mice. This finding suggests hydrogen-rich solution as a potential clinical therapeutic agent for AA

Dynamic changes in chemical composition and microbial community characteristics during pile-fermentation process of Phyllanthus emblica Linn. fruit

Pile-fermentation is a common processing step for Phyllanthus emblica L. fruit (PEF) in its producing area. This process enhances its flavor, reduces astringency, and increases its health benefits. However, the mechanism behind pile-fermentation and the key factors impacting PEF quality remain unknown, becoming an urgent challenge that limits its further application. To address this issue, 87 volatile compounds were analyzed by HS-SPME/GC-QQQ-MS/MS and identified acetic acid and ethyl acetate as distinguishing markers before and after fermentation. The results found that 2-methoxy-3-isobutylpyrazine contributes to the differences in odor after fermentation based on the odor intensity characteristic spectrum. Illumina Miseq sequencing of ITS1 region and 16SrDNA V4 region was performed to investigate the microbial succession during the pile-fermentation. A total of 4 phyla 34 genera of fungi and 15 phyla 61 genera of bacteria were detected in all samples. The results showed that the dominant bacteria had significant differences due to different habitats before fermentation, and the diversity increased after fermentation, while the fungal diversity exhibited the opposite trend. Aspergillus and the Unclassified_f_Necriaceae genus emerged as dominant genera after fermentation. Additionally, through UPLC-QTOF-MS analysis, we identified 18 differential components before and after fermentation. Among these, 5 compounds, such as 2-O-galloyl-1,4-galactolactone and 1-methyl-2-gallate galactose ester, showed a downward trend, whereas 13 compounds, including corilagin and chebulitic acid, exhibited an upward trend. These changes weakened astringency while improving sourness and aftertaste sweetness. The results of this study hold significant importance in clarifying the fermentation mechanism and improving the quality standards of PEF

A crack compensation strategy for highly stretchable conductors based on liquid metal inclusions

Crack control strategies have been proven very useful for enhancing the stretchability of metal film-based stretchable conductors. However, existing strategies often suffer from the drawbacks of complicated preparation and predefined effective directions. Here, we propose a crack compensation strategy for preparing conductors featured with high stretchability by using liquid metal microparticles (LMMPs)-embedded polydimethylsiloxane (PDMS) as the substrate with a thin film of gold (Au) sputtered on the surface. LMMPs can be elongated to connect the cracked Au film upon stretching, which can form a conductive “island-tunnel” (IT) architecture to compensate for the cracks and maintain the conductivity. The high performance of the stretchable conductor is demonstrated by using it as electrodes to record surface electromyography of human brachioradialis and monitor electrocorticography signals of a rat in normal and epileptic states. The developed strategy shows the potential to provide a new perspective for the fabrication of flexible electronics.</p