Finite-Volume QED Corrections to Decay Amplitudes in Lattice QCD

We demonstrate that the leading and next-to-leading finite-volume effects in the evaluation of leptonic decay widths of pseudoscalar mesons at $O(\alpha)$ are universal, i.e. they are independent of the structure of the meson. This is analogous to a similar result for the spectrum but with some fundamental differences, most notably the presence of infrared divergences in decay amplitudes. The leading non-universal, structure-dependent terms are of $O(1/L^2)$ (compared to the $O(1/L^3)$ leading non-universal corrections in the spectrum). We calculate the universal finite-volume effects, which requires an extension of previously developed techniques to include a dependence on an external three-momentum (in our case, the momentum of the final state lepton). The result can be included in the strategy proposed in Ref.\,\cite{Carrasco:2015xwa} for using lattice simulations to compute the decay widths at $O(\alpha)$, with the remaining finite-volume effects starting at order $O(1/L^2)$. The methods developed in this paper can be generalised to other decay processes, most notably to semileptonic decays, and hence open the possibility of a new era in precision flavour physics

Electromagnetic corrections to leptonic decay rates of charged pseudoscalar mesons: finite-volume effects

In Carrasco et al. we have recently proposed a method to calculate $O(e^2)$ electromagnetic corrections to leptonic decay widths of pseudoscalar mesons. The method is based on the observation that the infrared divergent contributions (that appear at intermediate stages of the calculation and that cancel in physical quantities thanks to the Bloch-Nordsieck mechanism) are universal, i.e. depend on the charge and the mass of the meson but not on its internal structure. In this talk we perform a detailed analysis of the finite-volume effects associated with our method. In particular we show that also the leading $1/L$ finite-volume effects are universal and perform an analytical calculation of the finite-volume leptonic decay rate for a point-like meson

First lattice calculation of the QED corrections to leptonic decay rates

The leading-order electromagnetic and strong isospin-breaking corrections to the ratio of $K_{\mu 2}$ and $\pi_{\mu 2}$ decay rates are evaluated for the first time on the lattice, following a method recently proposed. The lattice results are obtained using the gauge ensembles produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ dynamical quarks. Systematics effects are evaluated and the impact of the quenched QED approximation is estimated. Our result for the correction to the tree-level $K_{\mu 2} / \pi_{\mu 2}$ decay ratio is $-1.22\,(16) \%$ to be compared to the estimate $-1.12\,(21) \%$ based on Chiral Perturbation Theory and adopted by the Particle Data Group.Comment: 5 pages, 6 figures; extended supplemental material with 1 table and 1 figure, results unchange

Quark masses with Nf=2 twisted mass lattice QCD

We present the results of the recent high precision lattice calculation of the average up/down, strange and charm quark masses performed by ETMC with Nf=2 twisted mass Wilson fermions. The analysis includes data at four values of the lattice spacing and pion masses as low as ~270 MeV, allowing for accurate continuum limit and chiral extrapolation. The strange and charm masses are extracted by using several methods, based on different observables: the kaon and the eta_s meson for the strange quark and the D, D_s and eta_c mesons for the charm. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses in the MSbar scheme read: m_ud(2 GeV)= 3.6(2) MeV, m_s(2 GeV)=95(6) MeV and m_c(m_c)=1.28(4) GeV. We have also obtained the ratios m_s/m_ud=27.3(9) and m_c/m_s=12.0(3). Moreover, we provide the updated result for the bottom quark mass, m_b(m_b)=4.3(2) GeV, obtained using the method presented in 0909.3187 [hep-lat].Comment: 7 pages, 7 figures, talk given at the XXVIII International Symposium on Lattice Field Theory (Lattice 2010), June 14-19 2010, Villasimius, Ital

Leading isospin-breaking corrections to pion, kaon and charmed-meson masses with Twisted-Mass fermions

We present a lattice computation of the isospin-breaking corrections to pseudoscalar meson masses using the gauge configurations produced by the European Twisted Mass collaboration with $N_f = 2 + 1 + 1$ dynamical quarks at three values of the lattice spacing ($a \simeq 0.062, 0.082$ and $0.089$ fm) with pion masses in the range $M_\pi \simeq 210 - 450$ MeV. The strange and charm quark masses are tuned at their physical values. We adopt the RM123 method based on the combined expansion of the path integral in powers of the $d$- and $u$-quark mass difference ($\widehat{m}_d - \widehat{m}_u$) and of the electromagnetic coupling $\alpha_{em}$. Within the quenched QED approximation, which neglects the effects of the sea-quark charges, and after the extrapolations to the physical pion mass and to the continuum and infinite volume limits, we provide results for the pion, kaon and (for the first time) charmed-meson mass splittings, for the prescription-dependent parameters $\epsilon_{\pi^0}$, \epsilon_\gamma(\overline{MS}, 2~\mbox{GeV}), \epsilon_{K^0}(\overline{MS}, 2~\mbox{GeV}), related to the violations of the Dashen's theorem, and for the light quark mass difference (\widehat{m}_d - \widehat{m}_u)(\overline{MS}, 2~\mbox{GeV}).Comment: 47 pages, 20 figures, 4 tables; comments on QED and QCD splitting prescriptions added; version to appear in PR

Modulation by internal protons of native cyclic nucleotide-gated channels from retinal rods

Ion channels directly activated by cyclic nucleotides are present in the plasma membrane of retinal rod outer segments. These channels can be modulated by several factors including internal pH (pH(i)). Native cyclic nucleotide-gated channels were studied in excised membrane patches from the outer segment of retinal rods of the salamander. Channels were activated by cGMP or cAMP and currents as a function of voltage and cyclic nucleotide concentrations were measured as pH(i) was varied between 7.6 and 5.0. Increasing internal proton concentrations reduced the current activated by cGMP without modifying the concentration (K(1/2)) of cGMP necessary for half-activation of the maximal current. This effect could be well described as a reduction of single-channel current by protonation of a single acidic residue with a pK(1) of 5.1. When channels were activated by cAMP a more complex phenomenon was observed. K(1/2) for cAMP decreased by increasing internal proton concentration whereas maximal currents activated by cAMP increased by lowering pH(i) from 7.6 to 5.7-5.5 and then decreased from pH(i) 5.5 to 5.0. This behavior was attributed both to a reduction in single-channel current as measured with cGMP and to an increase in channel open probability induced by the binding of three protons to sites with a pK(2) of 6

Average up/down, strange and charm quark masses with Nf=2 twisted mass lattice QCD

We present a high precision lattice calculation of the average up/down, strange and charm quark masses performed with Nf=2 twisted mass Wilson fermions. The analysis includes data at four values of the lattice spacing and pion masses as low as ~270 MeV, allowing for accurate continuum limit and chiral extrapolation. The strange and charm masses are extracted by using several methods, based on different observables: the kaon and the eta_s meson for the strange quark and the D, D_s and eta_c mesons for the charm. The quark mass renormalization is carried out non-perturbatively using the RI-MOM method. The results for the quark masses in the MSbar scheme read: m_ud(2 GeV)= 3.6(2) MeV, m_s(2 GeV)=95(6) MeV and m_c(m_c)=1.28(4) GeV. We also obtain the ratios m_s/m_ud=27.3(9) and m_c/m_s=12.0(3).Comment: 20 pages, 5 figures. Typos corrected in eqs. (15)-(17). Version published in Phys. Rev.

Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock. a systematic review and meta-analysis

Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with prognosis. Global longitudinal strain (GLS) utilizing speckle-tracking echocardiography (STE) could be a better marker of intrinsic left ventricular (LV) function, reflecting myocardial deformation rather than displacement and volume changes. We sought to investigate the prognostic value of GLS in patients with sepsis and/or septic shock