Canal de Provence

Presented at the 2002 USCID/EWRI conference, Energy, climate, environment and water - issues and opportunities for irrigation and drainage on July 9-12 in San Luis Obispo, California.Includes bibliographical references.Measurement network on hydraulic system includes many sensors subject to failure or deviation, and spread over a huge area. In addition discharge and volume measurements in open channel hydraulic networks are characterized by large uncertainties. To overcome this kind of problem, in process control industrial applications, data reconciliation is more and more used. The objective of the data reconciliation is to take advantage of information redundancy on a system to make a cross-checking of real-time measurements. Using this information redundancy, a data reconciliation module allows to detect inconsistent measurements, measurement deviations and provides corrected values whether the initial measurements are valid, biased or invalid. A derived consequence is to better schedule the maintenance of sensors. A data reconciliation module, based on the measurements from the hydraulic network, has been recently developed and implemented in the SCP's supervisory system. The software has initially been used on a daily basis to check the measured flow on the main canal. It has then been adapted in order to run every 15 minutes on a distribution network including pipes, canals, and tanks. The paper presents first the theory of the Canal de Provence data reconciliation application. The basic model is an hydraulic network with a series of nodes corresponding to balance equations (inflows, outflows, and storage). Constrained data reconciliation is used in order to satisfy the non-negativity of the hydraulic variables and the mass balance relations. The results are corrected values for measured variables and proposed values for non-measured quantities. A statistical analysis of the results is performed. This analysis allows to evaluate the uncertainties attached to the estimated flows and volume values. It allows also to detect invalid measurements, drift of sensors and to decide which maintenance operations to perform. Secondly, field examples are presented: measured and re-estimated flow values with their standard deviations, detection of invalid sensors, performed maintenance operation. The data reconciliation is situated just after the measurement process and takes place in the decision process for diagnosis, identification and control

Medical French: A Practical Guide

Please enjoy this pertinent medical French dictionary with over 2000 words and phrases related to medicine and healthcare translated by George Washington University medical students. Inside are 19 chapters divided by specialty that encompass anatomy, labs, diagnostics, imaging, and medical terminology specific to each system. We hope that you will find this useful when interacting with and connecting to your French-speaking patients in the clinic and hospital

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Background: Drosophila melanogaster has one of best-described transcriptomes of any multicellular organism. Nevertheless, the paucity of 3′-sequencing data in this species precludes comprehensive assessment of alternative polyadenylation (APA), which is subject to broad tissue-specific control. Results: Here, we generate deep 3′-sequencing data from 23 developmental stages, tissues, and cell lines of D. melanogaster, yielding a comprehensive atlas of ~ 62,000 polyadenylated ends. These data broadly extend the annotated transcriptome, identify ~ 40,000 novel 3′ termini, and reveal that two-thirds of Drosophila genes are subject to APA. Furthermore, we dramatically expand the numbers of genes known to be subject to tissue-specific APA, such as 3′ untranslated region (UTR) lengthening in head and 3′ UTR shortening in testis, and characterize new tissue and developmental 3′ UTR patterns. Our thorough 3′ UTR annotations permit reassessment of post-transcriptional regulatory networks, via conserved miRNA and RNA binding protein sites. To evaluate the evolutionary conservation and divergence of APA patterns, we generate developmental and tissue-specific 3′-seq libraries from Drosophila yakuba and Drosophila virilis. We document broadly analogous tissue-specific APA trends in these species, but also observe significant alterations in 3′ end usage across orthologs. We exploit the population of functionally evolving poly(A) sites to gain clear evidence that evolutionary divergence in core polyadenylation signal (PAS) and downstream sequence element (DSE) motifs drive broad alterations in 3′ UTR isoform expression across the Drosophila phylogeny. Conclusions: These data provide a critical resource for the Drosophila community and offer many insights into the complex control of alternative tissue-specific 3′ UTR formation and its consequences for post-transcriptional regulatory networks

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

11 novembre 19341934/11/11 (A35,N12383)

Additional file 3: Table S2. of Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Coordinates of 3′ ends of D. melanogaster, D. yakuba, and D. virilis. Ends are associated with genes and respective genomic features or with intergenic space. Counts supporting the end in each tissue are reported. The tables can be found as gtf files in Additional files 4, 14, and 15. (XLSX 15309 kb

L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

09 novembre 19271927/11/09 (A28,N9825)

Assessment of racial and ethnic differences of atopic dermatitis severity and treatment patterns in a diverse outpatient cohort in the United States: a retrospective observational study

Previous population-based studies in the United States found racial/ethnic differences of atopic dermatitis (AD) severity and treatment patterns. It is unclear whether these differences are from differences of disease characteristics or disparities. To examine racial/ethnic differences in severity and treatment patterns in a diverse outpatient patient cohort of AD patients (n = 833). There were no significant associations of highest-reported body surface area (BSA; Fisher\u27s exact test, P = 0.19 and P = 0.44) or physician\u27s global assessment (PGA; P = 0.63 and P = 0.57) with race or ethnicity; nor interactions of race/ethnicity with gender or age as predictors of BSA or PGA. Asian and multiracial/other patients were more likely than White or Black patients to use topical calcineurin inhibitors (Chi-square, P = 0.01). Dupilumab use differed by race (Multiracial/other = 35.0%; White = 20.1%; Asian = 15.7%; Black = 13.6%; Chi-square, P = 0.03), but not ethnicity (P = 0.88). Use of oral corticosteroids (Chi-square, P = 0.74), immunosuppressants (P = 0.98) or GABAergics (P = 0.16) or NBUVB (P = 0.42) did not differ by race. There were no interactions of race/ethnicity with gender or age as predictors of treatment use. Similar treatment patterns were observed across racial/ethnic groups. Though, topical calcineurin inhibitors were more commonly used in Asian and multiracial/other patients; dupilumab use was more common in multiracial/other patients

Severe reactive infectious mucocutaneous eruption mimicking drug-induced epidermal necrolysis triggered by norovirus

Reactive infectious mucocutaneous eruption (RIME) is an eruptive mucositis with varying degrees of cutaneous involvement presumed to be due to an immunologic response to various infectious pathogens. Most reported cases occur after a prodromal upper respiratory illness. We present a patient with a particularly severe case mimicking drug-induced epidermal necrolysis found to be triggered by asymptomatic norovirus infection, a virus not previously reported in association with RIME