Comparación de perfiles de disolución de tabletas de patente y genéricas de tolbutamida y de productos comerciales de metformina

Tesis (Maestría en Ciencias con Especialidad en Química Analítica) UANLUANLhttp://www.uanl.mx

In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug

A matrix system was developed that releases ibuprofen (IB) over a 12-hour period and the influence of the polymer type and concentration on the release rate of the drug was evaluated. Tablets containing different concentrations of Carbopol (CP), hydroxypropyl methylcellulose (HPMC), or ethyl cellulose (EC) were prepared using direct compression and the drug content, content uniformity, hardness, friability, dissolution performance, and in vitro release kinetics were examined. Formulated tablets were found to be within acceptable limits for physical and chemical parameters. The release kinetics of the Carbopol(r)971P 8% formulation showed the best linearity (r 2 =0.977) in fitting zero-order kinetics, suggesting the release rate was time independent. The drug release from tablets containing 8% CP was extended over approximately 18 hours and the release kinetics were nearly linear, suggesting that this system has the potential to maintain constant plasma drug concentrations over 12 hours, which could reduce the frequency of administration and the occurrence of adverse effects associated with repeated administration of conventional IB tablets

Analysis of mortality during the winter seasons in Mexico from 2000 to 2012

To analyze mortality from all causes in Mexico during the winter months. Methods: Data was extracted and tabulated on monthly all-cause mortality in the general population from 2000 to 2012 from the INEGI database. Coeficients of seasonal variation in mortality were calculated. Results: In Mexico there was an increase of 14 % in mortality in the general population during winter. The more susceptible age groups were older people and children, with increases of 18% and 13% respectively. The months with low levels of mortality were April, October and September for children, adolescents and older people respectively. Conclusions: Important increases in winter mortality occur in Mexico

Comparación de la calidad de tabletas de patente, genéricas y elaboradas para el sector salud para control de diabetes

La calidad de los productos farmacéuticos es sin duda un factor de suma importancia para asegurar el pronto restablecimiento de la salud de los individuos, su bienestar y calidad de vida. Se llevó a cabo un estudio para comparar la calidad de tabletas de patente, genéricas y producidas para el sector salud de metformina y tolbutamida, medicamentos utilizados para el control de la diabetes mellitus. Se determinaron los perfiles de disolución, uniformidad de peso y contenido, valoración de principio activo y desintegración, tomando como base al producto de referencia Rastinon Hoechst para tolbutamida y Dabex en el caso de metformina para la comparación de los productos genéricos y elaborados para el sector salud. Los resultados muestran diferencias en el perfil de disolución in vitro para metformina del sector salud al compararse con el medicamento de referencia. En el caso de tolbutamida tanto el producto genérico como el elaborado para el sector salud mostraron perfiles de disolución similares al producto de referencia. Todos los productos estudia- dos cumplieron satisfactoriamente con los requerimientos de control de calidad, lo que se traduce en buena calidad de los medicamentos analizados