Toward Better Outcomes for Natural Resource Management Decisions - The Potential of Public Deliberation

The type of public participation or community consultation process used by communities to resolve natural resource management issues will have a major impact on the types of decisions which result. A familiar process is the "expert" model where expertise is delivered to the community rather than reflecting a true collaborative learning process with community members. An alternative is deliberation, a community-based process where community members engage incollaborative learning and find courses of action valuable to the community as a whole, and not those which represent just a few interests. This paper discusses two case studies - the development of Water Sharing Plans by River Management Committees in New South Wales, Australia, and concern over potential intensive livestock operations in Saline County, Missouri, USA - and compares how the different processes were used to resolve natural resource management issues.Resource /Energy Economics and Policy,

Alley Cropping: An Agroforestry Practice

Alley cropping is an agroforestry practice intended to place trees within agricultural cropland systems. The purpose is to enhance or add income diversity (both long and short range), reduce wind and water erosion, improve crop production, improve utilization of nutrients, improve wildlife habitat or aesthetics, and/or convert cropland to forest. The practice is especially attractive to landowners wishing to add economic stability to their farming system while protecting soil from erosion, water from contamination, and improving wildlife habitat

Alley Cropping: An Agroforestry Practice

Alley cropping is an agroforestry practice intended to place trees within agricultural cropland systems. The purpose is to enhance or add income diversity (both long and short range), reduce wind and water erosion, improve crop production, improve utilization of nutrients, improve wildlife habitat or aesthetics, and/or convert cropland to forest. The practice is especially attractive to landowners wishing to add economic stability to their farming system while protecting soil from erosion, water from contamination, and improving wildlife habitat

Rural Livelihoods and Agroforestry Practices in the Missouri Flood Plains

This paper was presented at the International Farming Systems Association - Small Farms in an Ever Changing World: Meeting the challenges of sustainable livelihoods and food security in diverse rural communities on Nov 17-20, 2002, in Lake Buena Vista, Florida.Agroforestry practices, new to many small farms in the United States, may offer many economic and environmental benefits. Small farmers in Northeast and Southeast Missouri were interviewed to understand the relationship between their knowledge and interest in agroforestry practices and their livelihood strategies. Different income diversification strategies were found. The Southeast, with richer cropland, has a more diversified crop portfolio. In the Northeast, crop livestock production systems and part-time farming prevail, reflecting a rural lifestyle option where some household members engage in off-farm activities. Given differences in production systems and income from agriculture, the study finds that those interviewed have some knowledge and interest in agroforestry practices. Windbreaks and riparian buffers ranked highest in knowledge and interest in the Southeast, where household strategies focus on commercial crops and there is concern for the environment. Windbreaks and forest farming were first in the Northeast, where farm households are concerned about the environment, future generations, and new economic opportunities. This finding coincides with perceptions of the importance of trees to the environment, future generations, and economic benefits.This work was funded under cooperative agreement CR 826704-01-0 with the US EPA. The results are the sole responsibility of the investigators at the University of Missouri Columbia, and may not represent the policies or positions of the Environmental Protection Agency

Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome

BackgroundMannose binding lectin (MBL) is a key mediator of both innate immunity and efferocytosis (phagocytosis of apoptotic cells) in the airway. Defective efferocytosis results in a net increase in apoptotic material that can undergo secondary necrosis, leading to tissue damage and chronic inflammation. We have shown reduced MBL and efferocytosis in other chronic inflammatory lung diseases; we therefore hypothesized that reduced MBL and efferocytosis in the airways may be a determinant of bronchiolitis obliterans syndrome (BOS) after lung transplantation.MethodsWe investigated MBL (enzyme-linked immunosorbent assay [ELISA]), MBL-mediated complement deposition (UC4, ELISA), and efferocytosis of apoptotic bronchial epithelial cells (flow cytometry) in bronchoalveolar lavage (BAL) and peripheral blood from 75 lung transplant recipients, comprising 16 with stable graft function, 34 stable with proven infection, 25 with BOS, and 14 healthy controls.ResultsIn plasma, MBL levels were highly variable (0-17.538 μg/ml), but increased in infected patients vs control (p = 0.09) or stable groups (p = 0.003). There was a similar increase in UC4 in infected patients and a significant correlation between MBL and UC4. There was no correlation between MBL and time after transplant. In BAL, MBL levels were less variable (0-73.3 ng/ml) and significantly reduced in patients with BOS vs controls and stable groups. Efferocytosis was significantly reduced in the BOS group vs control and stable groups (mean [SEM] control, 20% [1.3%]; stable, 20.5% [2.5%]; infected, 17.3% [2.8%]; BOS, 11.3% [1.5%], p = 0.04).ConclusionsLow levels of MBL in the airway may play a role in reduced efferocytosis, subsequent tissue damage, and BOS after lung transplantation.Sandra Hodge, Melinda Dean, Greg Hodge, M Holmes, Paul N Reynold

Defective lung macrophage function in lung cancer +/- chronic obstructive pulmonary disease (COPD/emphysema)-mediated by cancer cell production of PGE2?

In chronic obstructive pulmonary disease (COPD/emphysema) we have shown a reduced ability of lung and alveolar (AM) macrophages to phagocytose apoptotic cells (defective ‘efferocytosis’), associated with evidence of secondary cellular necrosis and a resultant inflammatory response in the airway. It is unknown whether this defect is present in cancer (no COPD) and if so, whether this results from soluble mediators produced by cancer cells. We investigated efferocytosis in AM (26 controls, 15 healthy smokers, 37 COPD, 20 COPD+ non small cell lung cancer (NSCLC) and 8 patients with NSCLC without COPD) and tumor and tumor-free lung tissue macrophages (21 NSCLC with/13 without COPD). To investigate the effects of soluble mediators produced by lung cancer cells we then treated AM or U937 macrophages with cancer cell line supernatant and assessed their efferocytosis ability. We qualitatively identified Arachidonic Acid (AA) metabolites in cancer cells by LC-ESI-MSMS, and assessed the effects of COX inhibition (using indomethacin) on efferocytosis. Decreased efferocytosis was noted in all cancer/COPD groups in all compartments. Conditioned media from cancer cell cultures decreased the efferocytosis ability of both AM and U937 macrophages with the most pronounced effects occurring with supernatant from SCLC (an aggressive lung cancer type). AA metabolites identified in cancer cells included PGE2. The inhibitory effect of PGE2 on efferocytosis, and the involvement of the COX-2 pathway were shown. Efferocytosis is decreased in COPD/emphysema and lung cancer; the latter at least partially a result of inhibition by soluble mediators produced by cancer cells that include PGE2.Francis C. Dehle, Violet R. Mukaro, Craig Jurisevic, David Moffat, Jessica Ahern, Greg Hodge, Hubertus Jersmann, Paul N. Reynolds, Sandra Hodg

Informatics and data mining tools and strategies for the Human Connectome Project

The Human Connectome Project (HCP) is a major endeavor that will acquire and analyze connectivity data plus other neuroimaging, behavioral, and genetic data from 1,200 healthy adults. It will serve as a key resource for the neuroscience research community, enabling discoveries of how the brain is wired and how it functions in different individuals. To fulfill its potential, the HCP consortium is developing an informatics platform that will handle: 1) storage of primary and processed data, 2) systematic processing and analysis of the data, 3) open access data sharing, and 4) mining and exploration of the data. This informatics platform will include two primary components. ConnectomeDB will provide database services for storing and distributing the data, as well as data analysis pipelines. Connectome Workbench will provide visualization and exploration capabilities. The platform will be based on standard data formats and provide an open set of application programming interfaces (APIs) that will facilitate broad utilization of the data and integration of HCP services into a variety of external applications. Primary and processed data generated by the HCP will be openly shared with the scientific community, and the informatics platform will be available under an open source license. This paper describes the HCP informatics platform as currently envisioned and places it into the context of the overall HCP vision and agenda

Episcopal Church of the Redeemer, Greensboro, Georgia

Episcopal Church of the Redeemer documentation involved creating a set of HABS (Historic American Building Survey) architectural drawings and a written historical report. The drawings and report are part of the permanent HABS collection in the Library of Congress.https://scholarworks.gsu.edu/history_heritagepreservation/1054/thumbnail.jp

Lectins offer new perspectives in the development of macrophage-targeted therapies for COPD/emphysema

We have previously shown that the defective ability of alveolar macrophages (AM) to phagocytose apoptotic cells (‘efferocytosis’) in chronic obstructive pulmonary disease/emphysema (COPD) could be therapeutically improved using the C-type lectin, mannose binding lectin (MBL), although the exact mechanisms underlying this effect are unknown. An S-type lectin, galectin-3, is also known to regulate macrophage phenotype and function, via interaction with its receptor CD98. We hypothesized that defective expression of galectin/CD98 would be associated with defective efferocytosis in COPD and that mechanisms would include effects on cytoskeletal remodeling and macrophage phenotype and glutathione (GSH) availability. Galectin-3 was measured by ELISA in BAL from controls, smokers and current/ex-smokers with COPD. CD98 was measured on AM using flow cytometry. We assessed the effects of galectin-3 on efferocytosis, CD98, GSH, actin polymerisation, rac activation, and the involvement of PI3K (using β-actin probing and wortmannin inhibition) in vitro using human AM and/or MH-S macrophage cell line. Significant decreases in BAL galectin-3 and AM CD98 were observed in BAL from both current- and ex-smoker COPD subjects vs controls. Galectin 3 increased efferocytosis via an increase in active GTP bound Rac1. This was confirmed with β-actin probing and the role of PI3K was confirmed using wortmannin inhibition. The increased efferocytosis was associated with increases in available glutathione and expression of CD98. We provide evidence for a role of airway lectins in the failed efferocytosis in COPD, supporting their further investigation as potential macrophage-targeted therapies.Violet R. Mukaro, Johan Bylund, Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N. Reynolds, Sandra Hodg