Evidence for involvement of both IKCa and SKCa channels in hyperpolarizing responses of the rat middle cerebral artery

Endothelium-derived hyperpolarizing factor responses in the rat middle cerebral artery are blocked by inhibiting IKCa channels alone, contrasting with peripheral vessels where block of both IKCa and SKCa is required. As the contribution of IKCa and SKCa to endothelium-dependent hyperpolarization differs in peripheral arteries, depending on the level of arterial constriction, we investigated the possibility that SKCa might contribute to equivalent hyperpolarization in cerebral arteries under certain conditions. METHODS: Rat middle cerebral arteries (approximately 175 microm) were mounted in a wire myograph. The effect of KCa channel blockers on endothelium-dependent responses to the protease-activated receptor 2 agonist, SLIGRL (20 micromol/L), were then assessed as simultaneous changes in tension and membrane potential. These data were correlated with the distribution of arterial KCa channels revealed with immunohistochemistry. RESULTS: SLIGRL hyperpolarized and relaxed cerebral arteries undergoing variable levels of stretch-induced tone. The relaxation was unaffected by specific inhibitors of IKCa (TRAM-34, 1 micromol/L) or SKCa (apamin, 50 nmol/L) alone or in combination. In contrast, the associated smooth-muscle hyperpolarization was inhibited, but only with these blockers in combination. Blocking nitric oxide synthase (NOS) or guanylyl cyclase evoked smooth-muscle depolarization and constriction, with both hyperpolarization and relaxation to SLIGRL being abolished by TRAM-34 alone, whereas apamin had no effect. Immunolabeling showed SKCa and IKCa within the endothelium. CONCLUSIONS: In the absence of NO, IKCa underpins endothelium-dependent hyperpolarization and relaxation in cerebral arteries. However, when NOS is active SKCa contributes to hyperpolarization, whatever the extent of background contraction. These changes may have relevance in vascular disease states where NO release is compromised and when the levels of SKCa expression may be altered

Will jams get worse when slow cars move over?

Motivated by an analogy with traffic, we simulate two species of particles (`vehicles'), moving stochastically in opposite directions on a two-lane ring road. Each species prefers one lane over the other, controlled by a parameter $0 \leq b \leq 1$ such that $b=0$ corresponds to random lane choice and $b=1$ to perfect `laning'. We find that the system displays one large cluster (`jam') whose size increases with $b$, contrary to intuition. Even more remarkably, the lane `charge' (a measure for the number of particles in their preferred lane) exhibits a region of negative response: even though vehicles experience a stronger preference for the `right' lane, more of them find themselves in the `wrong' one! For $b$ very close to 1, a sharp transition restores a homogeneous state. Various characteristics of the system are computed analytically, in good agreement with simulation data.Comment: 7 pages, 3 figures; to appear in Europhysics Letters (2005

Density Profile of the One-Dimensional Partially Asymmetric Simple Exclusion Process with Open Boundaries

The one-dimensional partially asymmetric simple exclusion process with open boundaries is considered. The stationary state, which is known to be constructed in a matrix product form, is studied by applying the theory of q-orthogonal polynomials. Using a formula of the q-Hermite polynomials, the average density profile is computed in the thermodynamic limit. The phase diagram for the correlation length, which was conjectured in the previous work[J. Phys. A {\bf 32} (1999) 7109], is confirmed.Comment: 24 pages, 6 figure

On Matrix Product Ground States for Reaction-Diffusion Models

We discuss a new mechanism leading to a matrix product form for the stationary state of one-dimensional stochastic models. The corresponding algebra is quadratic and involves four different matrices. For the example of a coagulation-decoagulation model explicit four-dimensional representations are given and exact expressions for various physical quantities are recovered. We also find the general structure of $n$-point correlation functions at the phase transition.Comment: LaTeX source, 7 pages, no figure

Electronic correlation effects and the Coulomb gap at finite temperature

We have investigated the effect of the long-range Coulomb interaction on the one-particle excitation spectrum of n-type Germanium, using tunneling spectroscopy on mechanically controllable break junctions. The tunnel conductance was measured as a function of energy and temperature. At low temperatures, the spectra reveal a minimum at zero bias voltage due to the Coulomb gap. In the temperature range above 1 K the Coulomb gap is filled by thermal excitations. This behavior is reflected in the temperature dependence of the variable-range hopping resitivity measured on the same samples: Up to a few degrees Kelvin the Efros-Shkovskii ln$R \propto T^{-1/2}$ law is obeyed, whereas at higher temperatures deviations from this law are observed, indicating a cross-over to Mott's ln$R \propto T^{-1/4}$ law. The mechanism of this cross-over is different from that considered previously in the literature.Comment: 3 pages, 3 figure

Finite Dimensional Representations of the Quadratic Algebra: Applications to the Exclusion Process

We study the one dimensional partially asymmetric simple exclusion process (ASEP) with open boundaries, that describes a system of hard-core particles hopping stochastically on a chain coupled to reservoirs at both ends. Derrida, Evans, Hakim and Pasquier [J. Phys. A 26, 1493 (1993)] have shown that the stationary probability distribution of this model can be represented as a trace on a quadratic algebra, closely related to the deformed oscillator-algebra. We construct all finite dimensional irreducible representations of this algebra. This enables us to compute the stationary bulk density as well as all correlation lengths for the ASEP on a set of special curves of the phase diagram.Comment: 18 pages, Latex, 1 EPS figur

The energy gap of intermediate-valent SmB6 studied by point-contact spectroscopy

We have investigated the intermediate valence narrow-gap semiconductor SmB6 at low temperatures using both conventional spear-anvil type point contacts as well as mechanically controllable break junctions. The zero-bias conductance varied between less than 0.01 mikrosiemens and up to 1 mS. The position of the spectral anomalies, which are related to the different activation energies and band gaps of SmB6, did not depend on the the contact size. Two different regimes of charge transport could be distinguished: Contacts with large zero - bias conductance are in the diffusive Maxwell regime. They had spectra with only small non-linearities. Contacts with small zero - bias conductance are in the tunnelling regime. They had larger anomalies, but still indicating a finite 45 % residual quasiparticle density of states at the Fermi level at low temperatures of T = 0.1 K. The density of states derived from the tunelling spectra can be decomposed into two energy-dependent parts with Eg = 21 meV and Ed = 4.5 meV wide gaps, respectively.Comment: 9 pages incl. 13 figure

Spurious phase in a model for traffic on a bridge

We present high-precision Monte Carlo data for the phase diagram of a two-species driven diffusive system, reminiscent of traffic across a narrow bridge. Earlier studies reported two phases with broken symmetry; the existence of one of these has been the subject of some debate. We show that the disputed phase disappears for sufficiently large systems and/or sufficiently low bulk mobility.Comment: 8 pages, 3 figures, JPA styl

Stability of a Nonequilibrium Interface in a Driven Phase Segregating System

We investigate the dynamics of a nonequilibrium interface between coexisting phases in a system described by a Cahn-Hilliard equation with an additional driving term. By means of a matched asymptotic expansion we derive equations for the interface motion. A linear stability analysis of these equations results in a condition for the stability of a flat interface. We find that the stability properties of a flat interface depend on the structure of the driving term in the original equation.Comment: 14 pages Latex, 1 postscript-figur

Remarks on the multi-species exclusion process with reflective boundaries

We investigate one of the simplest multi-species generalizations of the one dimensional exclusion process with reflective boundaries. The Markov matrix governing the dynamics of the system splits into blocks (sectors) specified by the number of particles of each kind. We find matrices connecting the blocks in a matrix product form. The procedure (generalized matrix ansatz) to verify that a matrix intertwines blocks of the Markov matrix was introduced in the periodic boundary condition, which starts with a local relation [Arita et al, J. Phys. A 44, 335004 (2011)]. The solution to this relation for the reflective boundary condition is much simpler than that for the periodic boundary condition