Colonic epithelial ion transport is not affected in patients with diverticulosis

<p>Abstract</p> <p>Background</p> <p>Colonic diverticular disease is a bothersome condition with an unresolved pathogenesis. It is unknown whether a neuroepithelial dysfunction is present. The aim of the study was two-fold; (1) to investigate colonic epithelial ion transport in patients with diverticulosis and (2) to adapt a miniaturized Modified Ussing Air-Suction (MUAS) chamber for colonic endoscopic biopsies.</p> <p>Methods</p> <p>Biopsies were obtained from the sigmoid part of the colon. 86 patients were included. All patients were referred for colonoscopy on suspicion of neoplasia and they were without pathological findings at colonoscopy (controls) except for diverticulosis in 22 (D-patients). Biopsies were mounted in MUAS chambers with an exposed area of 5 mm². Electrical responses to various stimulators and inhibitors of ion transport were investigated together with histological examination. The MUAS chamber was easy to use and reproducible data were obtained.</p> <p>Results</p> <p>Median basal short circuit current (SCC) was 43.8 μA·cm^-2(0.8 – 199) for controls and 59.3 μA·cm^-2(3.0 – 177.2) for D-patients. Slope conductance was 77.0 mS·cm^-2(18.6 – 204.0) equal to 13 Ω·cm²for controls and 96.6 mS·cm^-2(8.4 – 191.4) equal to 10.3 Ω·cm²for D-patients. Stimulation with serotonin, theophylline, forskolin and carbachol induced increases in SCC in a range of 4.9 – 18.6 μA·cm^-2, while inhibition with indomethacin, bumetanide, ouabain and amiloride decreased SCC in a range of 6.5 – 27.4 μA·cm^-2, and all with no significant differences between controls and D-patients. Histological examinations showed intact epithelium and lamina propria before and after mounting for both types of patients.</p> <p>Conclusion</p> <p>We conclude that epithelial ion transport is not significantly altered in patients with diverticulosis and that the MUAS chamber can be adapted for studies of human colonic endoscopic biopsies.</p

A triumph of ideological hairdressing? Intellectual life in the Brezhnev era reconsidered

Sandle was co-editor of this book with E. Bacon (50/50%) and also contributed another chapter ('Brezhnev and Developed Socialism: the ideology of Zastoi?', pp.165-187). He also contributed with Bacon (50/50%) the concluding chapter ('Brezhnev Reconsidered', pp.203-217)

Leonid Brezhnev in Moldavia, 1950-52: the making of a GenSek?

This is the first article dealing specifically with Brezhnev in Soviet Moldavia. The article draws mainly on recently disclosed files from the Archive of the Social-Political Organizations of the Republic of Moldova, the former archive of the Central Committee of Communist Party of Moldavia. The authors are trying to understand the importance of the period when Brezhnev served as First Secretary of Central Committee of Moldavia from 1950 to 1952 for his subsequent career. In order to understand better the results of Brezhnev’s rule in Moldavian SSR and the impact on his leadership style, the authors discuss the previous career of Brezhnev as well as the activity of the previous First Secretaries in Soviet Moldavia. One of the main results of Brezhnev period in Moldavia was the consolidation of kolkhozes. In a broader sense, since this period at least, Brezhnev favoured quantity over quality