Clasificación de transiciones de fase cuánticas mediante aprendizaje automático cuántico.

In this dissertation we discuss an example of quantum computing supremacy based on classification of quantum phase transitions. To do so, we focus our attention in the quantum Ising model and present the results of characterizing its phase transition making use of a machine learning algorithm used to do classification tasks and known as Support Vector Machines. <br /

Circuit Complexity through phase transitions: consequences in quantum state preparation

In this paper, we analyze the circuit complexity for preparing ground states of quantum many-body systems. In particular, how this complexity grows as the ground state approaches a quantum phase transition. We discuss different definitions of complexity, namely the one following the Fubini-Study metric or the Nielsen complexity. We also explore different models: Ising, ZZXZ or Dicke. In addition, different forms of state preparation are investigated: analytic or exact diagonalization techniques, adiabatic algorithms (with and without shortcuts), and Quantum Variational Eigensolvers. We find that the divergence (or lack thereof) of the complexity near a phase transition depends on the non-local character of the operations used to reach the ground state. For Fubini-Study based complexity, we extract the universal properties and their critical exponents. In practical algorithms, we find that the complexity depends crucially on whether or not the system passes close to a quantum critical point when preparing the state. For both VQE and Adiabatic algorithms, we provide explicit expressions and bound the growth of complexity with respect to the system size and the execution time, respectively.Comment: 25 pages, 12 figure

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

publishersversionPeer reviewe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Quantum kernels to learn the phases of quantum matter

Classical machine learning has succeeded in the prediction of both classical and quantum phases of matter. Notably, kernel methods stand out for their ability to provide interpretable results, relating the learning process with the physical order parameter explicitly. Here, we exploit quantum kernels instead. They are naturally related to the \emph{fidelity} and thus it is possible to interpret the learning process with the help of quantum information tools. In particular, we use a support vector machine (with a quantum kernel) to predict and characterize second order quantum phase transitions. We explain and understand the process of learning when the fidelity per site (rather than the fidelity) is used. The general theory is tested in the Ising chain in transverse field. We show that for small-sized systems, the algorithm gives accurate results, even when trained away from criticality. Besides, for larger sizes we confirm the success of the technique by extracting the correct critical exponent $\nu$. Finally, we present two algorithms, one based on fidelity and one based on the fidelity per site, to classify the phases of matter in a quantum processor.Comment: Published version. Two quantum algorithms added, one for the fidelity per sit

Tècniques científiques integrades

Obrir fitxer "menu.html" per obrir el llibre-eActivitats de l'assignatura 'Tècniques científiques integrades II' dels diferents graus de la Facultat de Cièncie

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field