Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival

Prevención de lesiones infantiles por accidente de tráfico

La prevención de los accidentes de tráfico es un tema de gran trascendencia social y un asunto de primera magnitud en salud pública. El grupo PrevInfad presenta en este documento la actualización de sus recomendaciones para la prevención de las lesiones por accidente de tráfico en niños y adolescentes, publicando en este caso un documento totalmente nuevo, que puede ser consultado en su versión íntegra en la página web del grupo (previnfad.aepap.org). La metodología incluye el diseño de un marco analítico, la formulación de preguntas estructuradas, la búsqueda y el análisis de la bibliografía. Dentro del apartado de accidentes de tráfico se van a considerar los ocasionados en vehículos a motor con el niño como pasajero o con el adolescente como conductor de ciclomotores u otros vehículos, los sufridos por peatones y las lesiones por caídas de bicicleta o por colisión de estas con vehículos a motor. También se incluye a los niños que se inician en la competición de ciclomotor. Es evidente que gran parte de las acciones preventivas corresponden a otros estamentos, si bien el pediatra tiene el deber de actuar como consejero y como grupo científico. Traffic accident prevention is an issue of social relevance and a very important public health matter. The working group PrevInfad presents in this document the update of its recommendations for traffic injury prevention in children and adolescents. The published document is brand new and can be consulted in full on the group’s website (previnfad.aepap.org). The methodology includes the design of an analytic framework, the formulation of structured questions, the search of the evidence and the analysis of the bibliography. Traffic accidents are considered those caused in motor vehicles with the child as a passenger or with the adolescent as a driver of motorcycles or other vehicles, the accidents suffered by pedestrians and the injuries by falls from bicycles or from collision of bicycles with motor vehicles. The document also includes children that initiate into motorcycle competition. Many of the preventive actions concern to other levels, nevertheless the pediatricians must act as advisers and as scientific group