Mapping the theories, content, and outcomes of family-based interventions for children and young people with gaming disorder: A scoping review protocol [version 1; peer review: 2 approved]

Background: Despite the growth of gaming disorders globally, evidence of the formal involvement of family in treating gaming disorders is limited. When children are affected by gaming disorder, the family may encounter challenges in managing the behavior and in the lack of information regarding the gaming disorder, resulting in inconsistent parenting, which may further exacerbate the problem. Thus, it is essential to involve the family in formal interventions. The current scoping review plans to identify the theories, content, and outcomes of family-based interventions for children and young people with gaming disorders. Methods: This scoping review will follow the Joanna Briggs Institute (JBI) methodology. The population, Concept, and Context (PCC) were used to develop the review question. The studies published in the indexed databases will be searched systematically, and the reference list of included full texts will be searched for relevant studies. Intervention studies published in English from January 2010 to December 2022 will be included. Two independent reviewers will screen the studies against eligibility criteria. The data will be extracted and presented in a tabular and narrative style. Discussion: This scoping review will help better understand content, outcomes, and theories underpinning family-based interventions for children and young people with gaming disorders. Findings will inform the stakeholders about the current topic and guide the potential research areas. Registration details: The protocol has been registered in Open Science Framework with the DOI: https://doi.org/10.17605/OSF.IO/TXWB

The Influence of Skin Pigmentation on Cochlear Functioning: A Study on Individuals with Normal Hearing Sensitivity

Background and Aim: Melanocytes are cells in the skin, hair, and eyes that generate pigment called melanin, which is primarily responsible for the pigmentation of these structures. These melanocytes, known as the Cochlear Melanocyte, are also present in the human ears (especially in the cochlea) and play a significant role in fostering endocochlear potential and preventing the odds of hearing loss. The current study investigated the relationship of skin pigment with cochlear function through distortion product otoacoustic emission in Indian skin type. Methods: A total of 120 participants aged between 17 to 25 were included using a purposive sampling technique. The subjects were further grouped based on a questionnaire on Fitzpatrick Skin Phototype (FSP) developed by Thomas Fitzpatrick (1975) and categorized as type III- type VI suitable for Indian skin types. Along with routine audiometric evaluations, the cochlear functioning was assessed using distortion product otoacoustic emissions. The standard group research design was used, and as data was normally distributed, multivariate analysis of variance was used to compare across groups. Results: The results of multivariate analysis of variance (MANOVA) showed no significant differences across the four groups for both amplitude and the slope of distortion product otoacoustic emissions. Conclusion: The present study using otoacoustic emissions revealed that the skin pigmentation did not affect cochlear functioning in the Indian population (type III through type VI) as seen in type I and II

o-Phthalic acid, a dead-end product in one of the two pathways of phenanthrene degradation in Pseudomonas sp. strain PP2

227-232Phenanthrene is degraded via either o-phthalic acid or 1, 2-dihydroxynaphthalene in bacteria. A soil isolate Pseudomonas sp. strain PP2 degrades phenanthrene as the sole source of carbon, but failed to utilize naphthalene [Prabhu and Phale (2003) Appl Microbiol Biotechnol 61:342-351]. Analysis of the phenanthrene-grown culture spent media of this strain by gas chromatography-mass spectrometry (GC-MS) showed accumulation of o-phthalic acid. The cell-free extract prepared from this strain showed activity of 1-hydroxy-2-naphthoic acid dioxygenase (1-H-2-NADO). The extract showed conversion of 1-hydroxy-2-naphthoic acid and 2-carboxybenzaldehyde to o-phthalic acid, as analyzed by thin layer chromatography and GC-MS. However, it failed to grow or respire on o-phthalic acid. These results suggest that besides 1, 2-dihydroxynaphthalene pathway, the strain has a truncated o-phthalic acid pathway for phenanthrene metabolism and excretes o-phthalic acid as a dead-end product, indicating the co-existence of two pathways. 1-H-2-NADO, the key enzyme of o-phthalic acid pathway is inducible, has pH optima of 7.5, does not require external addition of Fe(II) as a co-factor and is completely inhibited by 1,10-phenanthroline. Absence of product formation under anaerobic condition and stoichiometric consumption of 0.82 moles of O2 per mole of product formed confirmed the dioxygenase nature of the enzyme

Mapping the theories, content, and outcomes of family-based interventions for children and young people with gaming disorder: A Scoping Review Protocol

The proposed scoping review will be conducted in accordance with the JBI methodology for scoping reviews. In the case that the proposed protocol is amended, we will detail the change and provide justifications in the final review

Novel technologies: A weapon against tuberculosis

Tuberculosis (TB) is a leading chronic bacterial infection. Despite potentially curative pharmacotherapies being available for over 50 years, the length of the treatment and the pill burden can hamper patient lifestyle. Low compliance and adherence to administration schedules remain the main reasons for therapeutic failure and contribute to the development of multidrug-resistant strains. The design of novel antibiotics attempts to overcome drug resistance, to shorten the treatment course, and to reduce drug interactions. In this framework, nanotechnology appears as one of the promising approaches for the development of more effective medicines. The present review thoroughly overviews the development of novel microparticulate, encapsulation, and various other carrier-based drug delivery systems for incorporating the principal anti-TB agents. Drug delivery systems have been designed that either target the site of TB or reduce the dosing frequency with the aim of improving patient healthcare