Infrared and Thermal Analysis of Vanadyl(II) Barbiturate Complex

An usual method for the preparation of vanadyl(II) barbiturate complex was performed under the chemical reaction of vanadyl(II) sulfate with barbituric acid (H2L) and formulated as: [VO(HL)2].2H2O. This new barbiturate complex was synthesis and characterized by elemental analysis, molar conductivity, magnetic measurements, infrared spectral method and simultaneous thermal analysis (TG/DTG) techniques. The molar conductance measurements proved that barbiturate vanadyl(II) complex is non-electrolytes. The infrared spectra of the barbituric and vanadyl(II) complex are used to identify the mode of coordination. Kinetic and thermodynamic parameters (E*, ΔH*, ΔS* and ΔG*) of H2L ligand and its complex are estimated according to the DTG curves.Â

New chemical procedures for preparation of manganese(II), cobalt(II), zinc(II) and cadmium(II) carbonates under the catalytic behavior of metal ions: Discussion of infrared spectral bands

Abstract: Mn(II), Co(II), Zn(II) and Cd(II) carbonates, respectively, were achieved by a new chemical procedure under the reaction of aqueous solutions of metal ions (MnCl 2 , Co(NO 3 ) 2 , Zn(NO 3 ) 2 or CdCl 2 ), potassium iodide and urea with molar ratio 1:2:10, respectively, at ~ 90 o C for 3 hrs. The infrared spectra of the results indicate absence of the essential bands of urea, but existed of the characteristic bands of ionic carbonate, CO 3 2-. An important chemical mechanisms discussed the preparation of Mn(II), Co(II), Zn(II) and Cd(II) carbonate compounds were suggested

In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes

Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2O, and [Se(STG)2(Cl)2]Cl2, respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg2+, Ca2+, Cr3+, Zn2+, Cu2+, and Se4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone

Selenium/Chitosan-Folic Acid Metal Complex Ameliorates Hepatic Damage and Oxidative Injury in Male Rats Exposed to Sodium Fluoride

Continuous exposure to sodium fluoride (NaF) imbalances the oxidative status in the body. The current study investigated the effect of the selenium/chitosan-folic (Se/chitosan-folic acid) novel metal complex on oxidative injury and tissue damage in the hepatic tissues of male rats exposed to (NaF). Male rats received NaF (10.3 mg/kg) and Se/chitosan-folic acid (0.5 mg/Kg) orally for successive 30 days. Male rats exposed to NaF showed multi-histopathological alterations in the hepatic tissues including degenerative changes. NaF exposure elevated hepatic oxidative stress markers, lipid peroxidation, and lowered the antioxidant defense enzymes. Se/chitosan-folic acid novel complex supplementation significantly prevented hepatic injury, suppressed reactive oxygen species (ROS) generation and lipid peroxidation, and enhanced the antioxidant defense enzymes. In addition, Se/chitosan-folic acid supplementation improved the hepatic tissues of NaF-exposed male rats. In conclusion, the Se/chitosan-folic acid novel metal complex protects against NaF-induced oxidative injury and tissue injury in the hepatic tissues of male rats. The Se/chitosan-folic acid novel metal complex upregulated the hepatic tissues and enhanced the antioxidant defense enzymes in male rats

Infrared spectra and thermal degradation pathway of Zn(II), Cd(II) and Hg(II) alloxan diabetes adduct

Abstract: Alloxan diabetes complexes with Zn(II), Cd(II) and Hg(II) metal ions have been separated in solid form and characterized on the basis of elemental analysis, molar conductivity, mid infrared spectra. The thermal decomposition the solid complexes was studied. The ligational behavior of Cd(II) and Hg(II) occurs through the oxygen in position 2 and the nitrogen in position 1. Concerning Zn(II) complex the complexation involving the carbonyl group in position 4 (or 6) can be realized through both pyrimidine nitrogen atom and one of the hydroxyl groups in position 5. Keywords: Alloxan; Infrared spectra; thermal studies; chelation. I-INTRODUCTION Pyrimidine derivatives are known for their varied biological properties. Brugnatelli [1] was the first to isolate "Alloxan", a pyrimidine derivative in 1818 and later this compound was found to possess antineoplastic properties ISSN: 2319-8753 International Journal of Innovative Research in Science, Engineering and Technology Vol. 2, Issue 11, November 2013 Copyright to IJIRSET www.ijirset.com 6280 II-EXPERIMENTAL II-1-Materials and instrumentation All chemicals were reagent grade and were used without further purification. Alloxan was purchased from Fluka Chemical Co., ZnBr 2 , CdCl 2 and HgCl 2 (Merck Co.). Carbon, hydrogen and nitrogen contents were determined using a Perkin-Elmer CHN 2400. The metal content was found gravimetrically by converting the compounds into their corresponding oxides at 800 o C under air condition. IR spectra were recorded on Genesis II FT-IR Spectrometer in the (4000-400 cm -1 ) range with 40 scans in KBr discs. The UV-vis, spectra were determined in the DMSO solvent with concentration (1.00× 10 -3 M) for the alloxan and their complexes using Jenway 6405 Spectrophotometer with 1cm quartz cell, in the range 800-200 nm. Molar conductivities of freshly prepared 1.0×10 -3 mol/dm 3 DMSO solutions were measured using Jenway 4010 conductivity meter. Simultaneous TGA and DTA curves were obtained on a Rigaku 8150 thermoanalyser under dynamic nitrogen atmosphere, at a heating rate of 5 deg min -1 . Preparation of these two complexes followed mainly the same procedure as preparation of Zn(II) complex, but the weight of CdCl 2 and HgCl 2 were (0.201 gm, 1.0 mmol) and (0.271 gm, 1.0 mmol), respectively. The pH was adjusted at 7.5. II.2. Synthesis of metal complexes III-RESULTS AND DISCUSSION Alloxan is one of alterdentate ligand which offers metal ion more than one equivalent coordination site. In an alterdentate ligand there is, principally, always a rearrangement possible in which the metal is transferred from one site to another one. This can be either an inter-or intramolecular process. The rearrangement reaction is kinetically controlled by the activation energy and entropy experienced by the metal on the reaction path. The free energy difference is zero by definition, if the coordination sites are equivalen

Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—”ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)”

A newly synthesized zinc (II) oxide nanoparticle (ZnO-NPs) has been used as a disinfectant Nano-spray for the emerging corona virus (SARS-CoV-2). The synthesized obtained nanomaterial of (ZnO) was fully chemically characterized by using different spectroscopic analysis (FT-IR, UV and XRD) and surface analysis techniques. ZnO-Nps surface morphology and chemical purity has been investigated by transmission electron microscope (TEM), high resolution transmission electron microscope (HR-TEM), scanning electron microscopy (SEM) as well as energy dispersive X-ray analysis (EDX), Additionally Zeta potential and Zeta size distribution were measured and evaluated to confirm its nano-range scale. The synthesized Zno-NPs have been tested using 10% DMSO and ddH2O for estimation of antiviral activity against (SARS-CoV-2) by using cytotoxicity assay (CC50) and inhibitory concentration (IC50). The results revealed that (Zno-NPs) has high anti-SARS-CoV-2 activity at cytotoxic concentrations in vitro with non-significant selectivity index (CC50/IC50 ≤ 1). The current study results demonstrated the (ZnO-NPs) has potent antiviral activity at low concentration (IC50 = 526 ng/mL) but with some cytotoxic effect to the cell host by (CC50 = 292.2 ng/mL). We recommend using of (ZnO-NPs) as potent disinfectant against (SARS-Cov-2), but there are slight side effects on the cellular host, so we recommend more prospective studies on complexation of other compounds with (ZnO-NPs) in different concentrations to reduce its cellular toxicity and elevate its antiviral activity against SARS-CoV-2 activities

Chitosan/Selenium Nanoparticles Attenuate Diclofenac Sodium-Induced Testicular Toxicity in Male Rats

The detrimental effect of diclofenac sodium (Diclo-Na) on male reproductive organs is reported upon in this paper. Chitosan is a polysaccharide composed of various amounts of glucosamine. Chitosan nanoparticles (CH-NPs) have attracted much attention owing to their biomedical activity. Selenium (Se) has a vital role in nutrition, plays an important role in enhancing male reproduction, and has a wide range of free radical scavenging activities. However, the study of the impact of chitosan nanoparticles in combination with Se (IV) (CH-NPs/Se) on male reproductive toxicity associated with Diclo-Na administration is lacking in recent literature. The current study assessed the ameliorative effects of complexes of CH-NPs/Se (IV) on Diclo-Na and the ways in which they alter reproductive toxicity in male rats. Male rats were treated for 30 days successively, either with Diclo-Na (10 mg/kg) or co-treated with a CH-NPs/Se complex (280 mg/kg). Sperm characteristics, marker enzymes of testicular function, LH, FSH, and testosterone were evaluated in addition to oxidative stress markers and histological alterations. CH-NPs/Se significantly alleviated Diclo-Na-induced decline in sperm count and motility, testicular function enzymes, and levels of LH and testosterone in serum. Additionally, CH-NPs/Se co-administration at 280 mg/Kg, inhibited the Diclo-Na-induced decline of antioxidant enzyme activities and elevated oxidative stress indices and reactive free radicals in testicular homogenates of male rats. CH-NPs/Se (280 mg/kg) alone improved Diclo-Na and ameliorated histological damages in exposed rats. In conclusion, chitosan improved testicular function in Diclo-Na-treated rats by enhancing the testosterone hormone levels, ameliorating testicular tissue, and inhibiting markers of oxidative stress in male rats

Chitosan/Selenium Nanoparticles Attenuate Diclofenac Sodium-Induced Testicular Toxicity in Male Rats

The detrimental effect of diclofenac sodium (Diclo-Na) on male reproductive organs is reported upon in this paper. Chitosan is a polysaccharide composed of various amounts of glucosamine. Chitosan nanoparticles (CH-NPs) have attracted much attention owing to their biomedical activity. Selenium (Se) has a vital role in nutrition, plays an important role in enhancing male reproduction, and has a wide range of free radical scavenging activities. However, the study of the impact of chitosan nanoparticles in combination with Se (IV) (CH-NPs/Se) on male reproductive toxicity associated with Diclo-Na administration is lacking in recent literature. The current study assessed the ameliorative effects of complexes of CH-NPs/Se (IV) on Diclo-Na and the ways in which they alter reproductive toxicity in male rats. Male rats were treated for 30 days successively, either with Diclo-Na (10 mg/kg) or co-treated with a CH-NPs/Se complex (280 mg/kg). Sperm characteristics, marker enzymes of testicular function, LH, FSH, and testosterone were evaluated in addition to oxidative stress markers and histological alterations. CH-NPs/Se significantly alleviated Diclo-Na-induced decline in sperm count and motility, testicular function enzymes, and levels of LH and testosterone in serum. Additionally, CH-NPs/Se co-administration at 280 mg/Kg, inhibited the Diclo-Na-induced decline of antioxidant enzyme activities and elevated oxidative stress indices and reactive free radicals in testicular homogenates of male rats. CH-NPs/Se (280 mg/kg) alone improved Diclo-Na and ameliorated histological damages in exposed rats. In conclusion, chitosan improved testicular function in Diclo-Na-treated rats by enhancing the testosterone hormone levels, ameliorating testicular tissue, and inhibiting markers of oxidative stress in male rats

Using a Modified Polyamidoamine Fluorescent Dendrimer for Capturing Environment Polluting Metal Ions Zn²⁺, Cd²⁺, and Hg²⁺: Synthesis and Characterizations

One of the most pressing global concerns is how to provide a clean environment for future generations given the exacerbation of urban, agricultural, industrial, and economic activities due to the escalating size of the global population. A polyamidoamine (PAMAM) dendrimer peripherally modified with 4-N,N′-dimethylethylenediamine-1,8-naphthalmide as a chromophore was synthesized and utilized to capture hazardous heavy metal ions. This modified fluorescent dendrimer (FCD) was complexed with Group 12 metal ions (Zn2+, Cd2+, and Hg2+) at a 2:1 (metal: FCD) ratio. Electronic absorption, fluorescence emission, Infra-red (IR), and nuclear magnetic resonance (1H NMR) spectroscopies, conductivity, CHN elemental, thermogravimetry, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses were used to characterize the resulting metal complexes. These assays revealed that the synthesized complexes were yellow-colored, thermally stable, nanoscale-sized, and composed of [M2FCD]·4Cl2. Considerable spectral shifts were observed in the emission and absorption spectra of the FCD molecule after binding the Zn2+ ions, which can be used to differentiate the Zn2+ complex from the other two complexes. This work provides basic data to facilitate the detection, quantification, and removal of environmentally hazardous heavy metal ions through complexation with a fluorescent dendrimer