Aaron Spell Bankruptcy Declaration, 1842

Declaration of bankruptcy for A. Spell 20 February 1842, signed by District Judge Samuel J. Gholson, Jackson, Mississippi. Spell first filed for bankruptcy on 8 November 1842.https://scholarsjunction.msstate.edu/mss-spell-papers/1014/thumbnail.jp

d-Fold Partition Diamonds

In this work we introduce new combinatorial objects called $d$--fold partition diamonds, which generalize both the classical partition function and the partition diamonds of Andrews, Paule and Riese, and we set $r_d(n)$ to be their counting function. We also consider the Schmidt type $d$--fold partition diamonds, which have counting function $s_d(n).$ Using partition analysis, we then find the generating function for both, and connect the generating functions $\sum_{n= 0}^\infty s_d(n)q^n$ to Eulerian polynomials. This allows us to develop elementary proofs of infinitely many Ramanujan--like congruences satisfied by $s_d(n)$ for various values of $d$, including the following family: for all $d\geq 1$ and all $n\geq 0,$ $s_d(2n+1) \equiv 0 \pmod{2^d}.$Comment: 16 pages, 3 figures; v2: added a new result concerning Eulerian polynomials and several subsequent congruences for $s_{d}(n)$, and corrected a mistake in the proof of Proposition 1.

Genotype diversity of Trypanosoma cruzi in small rodents and Triatoma sanguisuga from a rural area in New Orleans, Louisiana

BACKGROUND: Chagas disease is an anthropozoonosis caused by the protozoan parasite Trypanosoma cruzi that represents a major public health problem in Latin America. Although the United States is defined as non-endemic for Chagas disease due to the rarity of human cases, the presence of T. cruzi has now been amply demonstrated as enzootic in different regions of the south of the country from Georgia to California. In southeastern Louisiana, a high T. cruzi infection rate has been demonstrated in Triatoma sanguisuga, the local vector in this area. However, little is known about the role of small mammals in the wild and peridomestic transmission cycles. METHODS: This study focused on the molecular identification and genotyping of T. cruzi in both small rodents and T. sanguisuga from a rural area of New Orleans, Louisiana. DNA extractions were prepared from rodent heart, liver, spleen and skeletal muscle tissues and from cultures established from vector feces. T. cruzi infection was determined by standard PCR using primers specific for the minicircle variable region of the kinetoplastid DNA (kDNA) and the highly repetitive genomic satellite DNA (satDNA). Genotyping of discrete typing units (DTUs) was performed by amplification of mini-exon and 18S and 24Sα rRNA genes and subsequent sequence analysis. RESULTS: The DTUs TcI, TcIV and, for the first time, TcII, were identified in tissues of mice and rats naturally infected with T. cruzi captured in an area of New Orleans, close to the house where the first human case of Chagas disease was reported in Louisiana. The T. cruzi infection rate in 59 captured rodents was 76%. The frequencies of the detected DTUs in such mammals were TcI 82%, TcII 22% and TcIV 9%; 13% of all infections contained more than one DTU. CONCLUSIONS: Our results indicate a probable presence of a considerably greater diversity in T. cruzi DTUs circulating in the southeastern United States than previously reported. Understanding T. cruzi transmission dynamics in sylvatic and peridomestic cycles in mammals and insect vectors will be crucial to estimating the risk of local, vector-borne transmission of T. cruzi to humans in the United States

Effect of Technology-Enabled Video Instruction on Senior Secondary School Students’ Performance in Selected Technical Drawing Concept in Ilorin

The study examined the effect of technology-enabled video instruction (TEVI) on senior secondary school students’ performance in selected technical drawing (TD) concepts in Ilorin. The sample for this study consists of an intact class in a senior secondary school in Ilorin. The research adopted a mixed method of quantitative and qualitative research, pre-experimental research of one-group pretest-posttest design. Technology-Enabled Video was used for data collection. The findings from the study revealed that TEVI had a positive effect on the academic performance of students taught selected TD concept, (63.1˃ 51.5), there was a significant difference in the pretest and posttest performance of students taught selected technical drawing concept using TEVI i.e. (df=15, t=-565, p=.000˂0.05). The study concluded that technology-enabled video instruction which is an improvised instructional aid did enhance the academic performance of the students. The study implies that proper integration of technology-based packages like TEVI for instructional delivery will adequately enhance students’ performance. The study Recommended that TEVI should be encouraged among teachers and students, as this will help to boost learners’ interest and provide learners the ability to learn in a direct, self-paced, and individualistic manner, which will, in turn, translate to better academic performance

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with functions that are different from the widely studied histone acetylation. While K(L-la) can be introduced by the acetyltransferase p300, histone delactylases enzymes remained unknown. Here, we report the systematic evaluation of zinc- and nicotinamide adenine dinucleotide-dependent histone deacetylases (HDACs) for their ability to cleave ε-N-L-lactyllysine marks. Our screens identified HDAC1-3 and SIRT1-3 as delactylases in vitro. HDAC1-3 show robust activity toward not only K(L-la) but also K(D-la) and diverse short-chain acyl modifications. We further confirmed the de-L-lactylase activity of HDACs 1 and 3 in cells. Together, these data suggest that histone lactylation is installed and removed by regulatory enzymes as opposed to spontaneous chemical reactivity. Our results therefore represent an important step toward full characterization of this pathway's regulatory elements